1. NF-κB
    Autophagy
  2. IKK
    LRRK2
  3. IKK 16 hydrochloride

IKK 16 hydrochloride 

Cat. No.: HY-13687A
Handling Instructions

IKK 16 hydrochloride is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively. IKK16 also inhibits leucine-rich repeat kinase-2 (LRRK2) with an IC50 of 50 nM.

For research use only. We do not sell to patients.

IKK 16 hydrochloride Chemical Structure

IKK 16 hydrochloride Chemical Structure

CAS No. : 1186195-62-9

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Top Publications Citing Use of Products

    IKK 16 hydrochloride purchased from MCE. Usage Cited in: Respir Res. 2017 Sep 20;18(1):174.

    BECs are pretreated with specific STAT6 inhibitor (AS1517499) or a selective IκB kinase inhibitor (IKK 16) for half an hour, then treated for 24 h in the presence or absence of 20 ng/mL IL-4. Immunofluorescence staining of MUC5AC protein is performed according to the Methods.

    IKK 16 hydrochloride purchased from MCE. Usage Cited in: Mol Immunol. 2018 Nov 13;104:69-78.

    Western analysis of proteins expression with treatment of IKK-16 or MG-132.

    IKK 16 hydrochloride purchased from MCE. Usage Cited in: Cell Death Dis. 2019 Apr 3;10(4):304. 

    IKK 16 treatment overwhelms the function of CT55 to promote the activation of p65 and IκBα degradation. HCT116 cells transfected with Flag-CT55 were treated with IKK 16 (20 mM) or DMSO for 2 h before TNF-α treatment. Western blotting is performed to detect the protein levels of IκBα, p-p65, and p65.

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    Description

    IKK 16 hydrochloride is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively[1]. IKK16 also inhibits leucine-rich repeat kinase-2 (LRRK2) with an IC50 of 50 nM[2].

    IC50 & Target[1]

    IKK2

    40 nM (IC50)

    IKK1

    200 nM (IC50)

    IKK

    70 nM (IC50)

    LRRK2

    50 nM (IC50)

    Molecular Weight

    520.09

    Formula

    C₂₈H₃₀ClN₅OS

    CAS No.

    1186195-62-9

    SMILES

    O=C(C1=CC=C(NC2=NC=CC(C3=CC4=CC=CC=C4S3)=N2)C=C1)N5CCC(N6CCCC6)CC5.[H]Cl

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
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    Product Name:
    IKK 16 hydrochloride
    Cat. No.:
    HY-13687A
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