1. NF-κB
    Autophagy
  2. IKK
    LRRK2
  3. IKK 16 hydrochloride

IKK 16 hydrochloride 

Cat. No.: HY-13687A
Handling Instructions

IKK 16 hydrochloride is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively. IKK16 also inhibits leucine-rich repeat kinase-2 (LRRK2) with an IC50 of 50 nM.

For research use only. We do not sell to patients.

IKK 16 hydrochloride Chemical Structure

IKK 16 hydrochloride Chemical Structure

CAS No. : 1186195-62-9

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Top Publications Citing Use of Products

    IKK 16 hydrochloride purchased from MCE. Usage Cited in: Respir Res. 2017 Sep 20;18(1):174.

    BECs are pretreated with specific STAT6 inhibitor (AS1517499) or a selective IκB kinase inhibitor (IKK 16) for half an hour, then treated for 24 h in the presence or absence of 20 ng/mL IL-4. Immunofluorescence staining of MUC5AC protein is performed according to the Methods.

    IKK 16 hydrochloride purchased from MCE. Usage Cited in: Mol Immunol. 2018 Nov 13;104:69-78.

    Western analysis of proteins expression with treatment of IKK-16 or MG-132.

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    • Biological Activity

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    Description

    IKK 16 hydrochloride is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively[1]. IKK16 also inhibits leucine-rich repeat kinase-2 (LRRK2) with an IC50 of 50 nM[2].

    IC50 & Target[1]

    IKK2

    40 nM (IC50)

    IKK1

    200 nM (IC50)

    IKK

    70 nM (IC50)

    LRRK2

    50 nM (IC50)

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
    Molecular Weight

    520.09

    Formula

    C₂₈H₃₀ClN₅OS

    CAS No.

    1186195-62-9

    SMILES

    O=C(C1=CC=C(NC2=NC=CC(C3=CC4=CC=CC=C4S3)=N2)C=C1)N5CCC(N6CCCC6)CC5.[H]Cl

    Shipping

    Room temperature in continental US; may vary elsewhere

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    Product Name:
    IKK 16 hydrochloride
    Cat. No.:
    HY-13687A
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    IKK 16 hydrochloride

    Cat. No.: HY-13687A