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  3. Protein kinase D inhibitor 1

Protein kinase D inhibitor 1 

Cat. No.: HY-151372
Handling Instructions

Protein kinase D inhibitor 1 (compound 17m) is a pan-PKD inhibitor, with IC50 values ranging from 17 to 35 nM. Protein kinase D inhibitor 1 inhibits PKD-dependent cortactin phosphorylation.

For research use only. We do not sell to patients.

Protein kinase D inhibitor 1 Chemical Structure

Protein kinase D inhibitor 1 Chemical Structure

CAS No. : 2489320-03-6

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Description

Protein kinase D inhibitor 1 (compound 17m) is a pan-PKD inhibitor, with IC50 values ranging from 17 to 35 nM. Protein kinase D inhibitor 1 inhibits PKD-dependent cortactin phosphorylation[1].

IC50 & Target

PKD3

17 ± 8 nM (IC50)

PKD2

35 ± 5 nM (IC50)

PKD1

35 ± 10 nM (IC50)

In Vitro

Protein kinase D inhibitor 1 (compound 17m) displays excellent PKD2 inhibition with almost no remaining kinase activity at 1 μM[1].
Protein kinase D inhibitor 1 displays only weak antiproliferative activity, and does not significantly affect PANC-1 cell proliferation at a concentration of 5 μM[1].
Protein kinase D inhibitor 1 (0-100 μM, 72 h) shows antitumor activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: LN-229, Capan-1, DND-41, HL-60, Z-138, NCI-H460, HCT-116, K-562
Concentration: 0-100 μM
Incubation Time: 72 h
Result: Inhibited of tumor cell growth of LN-229, Capan-1, DND-41, HL-60, Z-138, NCI-H460, HCT-116, and K-562, with IC50 values of 80.6 ± 7, 40.7 ± 14.5, 42.7 ± 4.9, 17.9 ± 4.1, 35.3 ± 10.4, >95.8, >100, and >100, respectively.
Molecular Weight

347.42

Formula

C19H21N7

CAS No.
SMILES

NC1=C2C(N(CC3CCNCC3)N=C2C4=CNC5=C4C=CC=C5)=NC=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Protein kinase D inhibitor 1
Cat. No.:
HY-151372
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