2. TGF-beta/Smad Stem Cell/Wnt PI3K/Akt/mTOR
  3. TGF-β Receptor GSK-3 β-catenin
  4. BMP agonist 1

BMP agonist 1 (compound 2 b) is a small-molecule agonist of bone morphogenic protein (BMP). BMP induces C2C12 cell differentiation with BMP and highly depends on active BMP signaling. BMP agonist 1 inhibits GSK3β, increases β-catenin signaling and synergistically regulates Id2and Id3 expression. BMP agonist 1 is used in diseases and defects of the skeleton research.

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BMP agonist 1 Chemical Structure

BMP agonist 1 Chemical Structure

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BMP agonist 1 Related Antibodies

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Description

BMP agonist 1 (compound 2 b) is a small-molecule agonist of bone morphogenic protein (BMP). BMP induces C2C12 cell differentiation with BMP and highly depends on active BMP signaling. BMP agonist 1 inhibits GSK3β, increases β-catenin signaling and synergistically regulates Id2and Id3 expression. BMP agonist 1 is used in diseases and defects of the skeleton research[1].

In Vitro

BMP agonist 1 (0.01-10 μM, 24 h) reduces the proliferation of C2C12 cells[1].
BMP agonist 1 (0.5-1 μM, 2 h) inhibits GSK3β, increases β-catenin signaling and synergistically regulates Id2 and Id3 expression in C2C12 cells[1].
BMP agonist 1 (0.01-10 μM) potently promotes the osteogenic differentiation (Alp activity) of the canonical BMP potentiator Chromenone 1 (HY-143891) in C2C12 cells when in combination with Chromenone 1 (0.5−1 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BMP agonist 1 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: C2C12 cells
Concentration: 0.01-10 μM
Incubation Time: 24, 72 h
Result: Differentiaed in C2C12 osteoblast at the low-dose BMP-4 (7.5 ng/mL).
Reduced the cell numbers and stopped the proliferation at higher concentrations.
Highly induced Id1 and Id3, elevated Runx2 levels.

Cell Differentiation Assay[1]

Cell Line: C2C12 cells
Concentration: 0.01-10 μM (in combination with (0.05, 0.2, 0.5, or 1 μM Chromenone 1)
Incubation Time:
Result: Highly overadditive effects and increased potency with Chromenone 1.
Reached the highest synergy scores (i.e., delta scores) at a concentration of 0.3 μM with 0.5−1 μM Chromenone 1.
Molecular Weight

392.36

Formula

C21H16N2O6
SMILES

OC1=CC2=C(C=C1)NC3=C2C(C(N4)=O)=C(C5=CC(OC)=C(C(OC)=C53)OC)C4=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BMP agonist 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMP agonist 1BMP agonist1BMP agonist-1TGF-β ReceptorGSK-3β-cateninTransforming growth factor beta receptorsGlycogen synthase kinase-3Glycogen synthase kinase 3Beta cateninC2C12BMPbone morphogenic proteinInhibitorinhibitorinhibit

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