BMP agonist 1

Cat. No.: HY-155705: Data Sheet
SDS
Handling Instructions
FAQs
Technical Support

BMP agonist 1 (compound 2 b) is a small-molecule agonist of bone morphogenic protein (BMP). BMP induces C2C12 cell differentiation with BMP and highly depends on active BMP signaling. BMP agonist 1 inhibits GSK3β, increases β-catenin signaling and synergistically regulates Id2and Id3 expression. BMP agonist 1 is used in diseases and defects of the skeleton research.

For research use only. We do not sell to patients.

BMP agonist 1 Chemical Structure

Size	Price	Stock
5 mg		Ask For Quote & Lead Time
10 mg		Ask For Quote & Lead Time
25 mg		Ask For Quote & Lead Time
50 mg		Ask For Quote & Lead Time
100 mg		Ask For Quote & Lead Time

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GSK-3 GSK-3α GSK-3β

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

BMP agonist 1 (0.01-10 μM, 24 h) reduces the proliferation of C2C12 cells^[1].
BMP agonist 1 (0.5-1 μM, 2 h) inhibits GSK3β, increases β-catenin signaling and synergistically regulates Id2 and Id3 expression in C2C12 cells^[1].
BMP agonist 1 (0.01-10 μM) potently promotes the osteogenic differentiation (Alp activity) of the canonical BMP potentiator Chromenone 1 (HY-143891) in C2C12 cells when in combination with Chromenone 1 (0.5−1 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	C2C12 cells
Concentration:	0.01-10 μM
Incubation Time:	24, 72 h
Result:	Differentiaed in C2C12 osteoblast at the low-dose BMP-4 (7.5 ng/mL). Reduced the cell numbers and stopped the proliferation at higher concentrations. Highly induced Id1 and Id3, elevated Runx2 levels.

Cell Differentiation Assay^[1]

Cell Line:	C2C12 cells
Concentration:	0.01-10 μM (in combination with (0.05, 0.2, 0.5, or 1 μM Chromenone 1)
Incubation Time:
Result:	Highly overadditive effects and increased potency with Chromenone 1. Reached the highest synergy scores (i.e., delta scores) at a concentration of 0.3 μM with 0.5−1 μM Chromenone 1.

Molecular Weight

392.36

Formula

C₂₁H₁₆N₂O₆

Appearance

Solid

Color

Orange to red

SMILES

OC1=CC2=C(C=C1)NC3=C2C(C(N4)=O)=C(C5=CC(OC)=C(C(OC)=C53)OC)C4=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (127.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5487 mL	12.7434 mL	25.4868 mL
5 mM	0.5097 mL	2.5487 mL	5.0974 mL
10 mM	0.2549 mL	1.2743 mL	2.5487 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Data Sheet (280 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. Riege D, et al. Identification of Maleimide-Fused Carbazoles as Novel Noncanonical Bone Morphogenetic Protein Synergizers. ACS Pharmacol Transl Sci. 2023 Jul 19;6(8):1207-1220. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5487 mL	12.7434 mL	25.4868 mL	63.7170 mL
	5 mM	0.5097 mL	2.5487 mL	5.0974 mL	12.7434 mL
	10 mM	0.2549 mL	1.2743 mL	2.5487 mL	6.3717 mL
	15 mM	0.1699 mL	0.8496 mL	1.6991 mL	4.2478 mL
	20 mM	0.1274 mL	0.6372 mL	1.2743 mL	3.1858 mL
	25 mM	0.1019 mL	0.5097 mL	1.0195 mL	2.5487 mL
	30 mM	0.0850 mL	0.4248 mL	0.8496 mL	2.1239 mL
	40 mM	0.0637 mL	0.3186 mL	0.6372 mL	1.5929 mL
	50 mM	0.0510 mL	0.2549 mL	0.5097 mL	1.2743 mL
	60 mM	0.0425 mL	0.2124 mL	0.4248 mL	1.0619 mL
	80 mM	0.0319 mL	0.1593 mL	0.3186 mL	0.7965 mL
	100 mM	0.0255 mL	0.1274 mL	0.2549 mL	0.6372 mL

BMP agonist 1 Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMP agonist 1BMP agonist1BMP agonist-1TGF-β ReceptorGSK-3β-cateninTransforming growth factor beta receptorsGlycogen synthase kinase-3Glycogen synthase kinase 3Beta cateninC2C12BMPbone morphogenic proteinInhibitorinhibitorinhibit

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