PRKCA - protein kinase C alpha Gene
Also Known as AAG6; PKCA; PRKACA; PKCI+/-; PKCalpha; PKC-alpha
Species: Homo sapiens
About PRKCA
This gene has 5 transcripts (splice variants), 284 orthologues and 9 paralogues. Ubiquitous expression in brain (RPKM 12.7), adrenal (RPKM 6.5) and 22 other tissues.
Summary
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and CA(2+) handling in myocytes. [provided by RefSeq, Jul 2008]
PRKCA Products (11)
| mRNA | Protein | Name |
|---|---|---|
| XR_001752558.2 | ||
| XM_047436389.1 | XP_047292345.1 | protein kinase C alpha type isoform X5 |
| XM_017024836.3 | XP_016880325.1 | protein kinase C alpha type isoform X1 |
| XR_007065317.1 | ||
| XM_017024837.2 | XP_016880326.1 | protein kinase C alpha type isoform X2 |
| XM_047436388.1 | XP_047292344.1 | protein kinase C alpha type isoform X4 |
| XR_007065315.1 | ||
| XM_024450829.2 | XP_024306597.1 | protein kinase C alpha type isoform X3 |
| XM_024450830.2 | XP_024306598.1 | protein kinase C alpha type isoform X3 |
| NM_002737.3 | NP_002728.2 | protein kinase C alpha type |
| XR_007065316.1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables calcium,diacylglycerol-dependent serine/threonine kinase activity |
IDA
IDA: Inferred from direct assay
|
25313067 | GOA |
| enables calcium,diacylglycerol-dependent serine/threonine kinase activity |
IMP
IMP: Inferred from mutant phenotype
|
33934390 | GOA |
| enables diacylglycerol-dependent serine/threonine kinase activity |
EXP
EXP: Inferred from Experiment
|
7520444 | GOA |
| enables enzyme binding |
IDA
IDA: Inferred from direct assay
|
18556656 | GOA |
| enables histone H3T6 kinase activity |
IDA
IDA: Inferred from direct assay
|
20228790 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
12571249 | GOA |
| enables protein kinase activity |
IDA
IDA: Inferred from direct assay
|
10770950 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| is active in ciliary basal body |
IDA
IDA: Inferred from direct assay
|
33934390 | GOA |
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
15632189 | GOA |
| located in cytosol |
IDA
IDA: Inferred from direct assay
|
17983652 | GOA |
| located in endoplasmic reticulum |
IDA
IDA: Inferred from direct assay
|
18556656 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
15632189 | GOA |
PRKCA Protein Structure
C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (37 - 87)
C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (102 - 153)
C2: C2 domain (173 - 259)
Pkinase: Protein kinase domain (340 - 583)
Pkinase_C: Protein kinase C terminal domain (624 - 662)
- 0
- 200
- 400
- 600
- 672 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
protein kinase C alpha type |
|
PRKCA Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
PRKCA | P17252 | HOXB13 | Homo sapiens | Q92826 | 32814053 | |
|
Intra
|
PRKCA | P17252 | HOXB13 | Homo sapiens | Q92826 | 32814053 | |
|
Intra
|
PRKCA | P17252 | HOXB13 | Homo sapiens | Q92826 | 32814053 | |
|
Intra
|
PRKCA | P17252 | SYNGR3 | Homo sapiens | O43761 | 32814053 | |
|
Intra
|
PRKCA | P17252 | SYNGR3 | Homo sapiens | O43761 | 32814053 | |
|
Intra
|
PRKCA | P17252 | SYNGR3 | Homo sapiens | O43761 | 32814053 | |
|
Intra
|
PRKCA | P17252 | BANP | Homo sapiens | Q8N9N5-2 | 32814053 | |
|
Intra
|
PRKCA | P17252 | BANP | Homo sapiens | Q8N9N5-2 | 32814053 | |
|
Intra
|
PRKCA | P17252 | BANP | Homo sapiens | Q8N9N5-2 | 32814053 | |
|
Intra
|
PRKCA | P17252 | IFT43 | Homo sapiens | Q96FT9-2 | 32814053 | |
|
Intra
|
PRKCA | P17252 | IFT43 | Homo sapiens | Q96FT9-2 | 32814053 | |
|
Intra
|
PRKCA | P17252 | IFT43 | Homo sapiens | Q96FT9-2 | 32814053 | |
|
Intra
|
PRKCA | P17252 | ZNF444 | Homo sapiens | Q8N0Y2-2 | 32814053 | |
|
Intra
|
PRKCA | P17252 | ZNF444 | Homo sapiens | Q8N0Y2-2 | 32814053 | |
|
Intra
|
PRKCA | P17252 | ZNF444 | Homo sapiens | Q8N0Y2-2 | 32814053 | |
|
Intra
|
PRKCA | P17252 | WWOX | Homo sapiens | Q9NZC7-5 | 32814053 | |
|
Intra
|
PRKCA | P17252 | WWOX | Homo sapiens | Q9NZC7-5 | 32814053 | |
|
Intra
|
PRKCA | P17252 | WWOX | Homo sapiens | Q9NZC7-5 | 32814053 | |
|
Intra
|
PRKCA | P17252 | SDHC | Homo sapiens | Q99643 | 32814053 | |
|
Intra
|
PRKCA | P17252 | SDHC | Homo sapiens | Q99643 | 32814053 | |
|
Intra
|
PRKCA | P17252 | SDHC | Homo sapiens | Q99643 | 32814053 | |
|
Intra
|
PRKCA | P17252 | FRMD6 | Homo sapiens | Q96NE9-2 | 32814053 | |
|
Intra
|
PRKCA | P17252 | FRMD6 | Homo sapiens | Q96NE9-2 | 32814053 | |
|
Intra
|
PRKCA | P17252 | FRMD6 | Homo sapiens | Q96NE9-2 | 32814053 | |
|
Intra
|
PRKCA | P17252 | MED19 | Homo sapiens | A0JLT2-2 | 32814053 | |
|
Intra
|
PRKCA | P17252 | MED19 | Homo sapiens | A0JLT2-2 | 32814053 | |
|
Intra
|
PRKCA | P17252 | MED19 | Homo sapiens | A0JLT2-2 | 32814053 | |
|
Intra
|
PRKCA | P17252 | IL3RA | Homo sapiens | P26951 | 32814053 | |
|
Intra
|
PRKCA | P17252 | IL3RA | Homo sapiens | P26951 | 32814053 | |
|
Intra
|
PRKCA | P17252 | IL3RA | Homo sapiens | P26951 | 32814053 | |
|
Intra
|
PRKCA | P17252 | FSCN2 | Homo sapiens | O14926 | 32814053 | |
|
Intra
|
PRKCA | P17252 | FSCN2 | Homo sapiens | O14926 | 32814053 | |
|
Intra
|
PRKCA | P17252 | FSCN2 | Homo sapiens | O14926 | 32814053 | |
|
Intra
|
PRKCA | P17252 | CPN1 | Homo sapiens | P15169 | 32814053 | |
|
Intra
|
PRKCA | P17252 | CPN1 | Homo sapiens | P15169 | 32814053 | |
|
Intra
|
PRKCA | P17252 | VNN2 | Homo sapiens | O95498 | 32814053 | |
|
Intra
|
PRKCA | P17252 | VNN2 | Homo sapiens | O95498 | 32814053 | |
|
Intra
|
PRKCA | P17252 | VNN2 | Homo sapiens | O95498 | 32814053 | |
|
Intra
|
PRKCA | P17252 | ZNF248 | Homo sapiens | Q05CR2 | 32814053 | |
|
Intra
|
PRKCA | P17252 | ZNF248 | Homo sapiens | Q05CR2 | 32814053 | |
|
Intra
|
PRKCA | P17252 | ZNF248 | Homo sapiens | Q05CR2 | 32814053 | |
|
Intra
|
PRKCA | P17252 | SP2 | Homo sapiens | Q9BRW5 | 32814053 | |
|
Intra
|
PRKCA | P17252 | SP2 | Homo sapiens | Q9BRW5 | 32814053 | |
|
Intra
|
PRKCA | P17252 | SP2 | Homo sapiens | Q9BRW5 | 32814053 | |
|
Intra
|
PRKCA | P17252 | RMND1 | Homo sapiens | Q9NWS8-3 | 32814053 | |
|
Intra
|
PRKCA | P17252 | RMND1 | Homo sapiens | Q9NWS8-3 | 32814053 | |
|
Intra
|
PRKCA | P17252 | RMND1 | Homo sapiens | Q9NWS8-3 | 32814053 | |
|
Intra
|
PRKCA | P17252 | BAGE | Homo sapiens | Q13072 | 32814053 | |
|
Intra
|
PRKCA | P17252 | BAGE | Homo sapiens | Q13072 | 32814053 | |
|
Intra
|
PRKCA | P17252 | BAGE | Homo sapiens | Q13072 | 32814053 | |
|
Intra
|
PRKCA | P17252 | GPR160 | Homo sapiens | Q9UJ42 | 32814053 | |
|
Intra
|
PRKCA | P17252 | GPR160 | Homo sapiens | Q9UJ42 | 32814053 | |
|
Intra
|
PRKCA | P17252 | GPR160 | Homo sapiens | Q9UJ42 | 32814053 | |
|
Intra
|
PRKCA | P17252 | ZFYVE21 | Homo sapiens | Q9BQ24 | 32814053 | |
|
Intra
|
PRKCA | P17252 | ZFYVE21 | Homo sapiens | Q9BQ24 | 32814053 | |
|
Intra
|
PRKCA | P17252 | ZFYVE21 | Homo sapiens | Q9BQ24 | 32814053 | |
|
Intra
|
PRKCA | P17252 | EGFR | Homo sapiens | P00533 | 24658140 | |
|
Intra
|
PRKCA | P17252 | MAPK11 | Homo sapiens | Q15759 | 32814053 | |
|
Intra
|
PRKCA | P17252 | MAPK11 | Homo sapiens | Q15759 | 32814053 | |
|
Intra
|
PRKCA | P17252 | MAPK11 | Homo sapiens | Q15759 | 32814053 | |
|
Intra
|
PRKCA | P17252 | H4C16 | Homo sapiens | P62805 | 32814053 | |
|
Intra
|
PRKCA | P17252 | H4C16 | Homo sapiens | P62805 | 32814053 | |
|
Intra
|
PRKCA | P17252 | H4C16 | Homo sapiens | P62805 | 32814053 | |
|
Intra
|
PRKCA | P17252 | EIF3E | Homo sapiens | P60228 | 32814053 | |
|
Intra
|
PRKCA | P17252 | EIF3E | Homo sapiens | P60228 | 32814053 | |
|
Intra
|
PRKCA | P17252 | EIF3E | Homo sapiens | P60228 | 32814053 | |
|
Intra
|
PRKCA | P17252 | RPL35A | Homo sapiens | P18077 | 32814053 | |
|
Intra
|
PRKCA | P17252 | RPL35A | Homo sapiens | P18077 | 32814053 | |
|
Intra
|
PRKCA | P17252 | RPL35A | Homo sapiens | P18077 | 32814053 | |
|
Intra
|
PRKCA | P17252 | SDC4 | Homo sapiens | P31431 | 12571249 | |
|
Intra
|
PRKCA | P17252 | MAP3K9 | Homo sapiens | P80192 | 32814053 | |
|
Intra
|
PRKCA | P17252 | MAP3K9 | Homo sapiens | P80192 | 32814053 | |
|
Intra
|
PRKCA | P17252 | MAP3K9 | Homo sapiens | P80192 | 32814053 | |
|
Intra
|
PRKCA | P17252 | MAGEH1 | Homo sapiens | Q9H213 | 32814053 | |
|
Intra
|
PRKCA | P17252 | MAGEH1 | Homo sapiens | Q9H213 | 32814053 | |
|
Intra
|
PRKCA | P17252 | MAGEH1 | Homo sapiens | Q9H213 | 32814053 | |
|
Intra
|
PRKCA | P17252 | ARL6IP4 | Homo sapiens | Q66PJ3-4 | 32814053 | |
|
Intra
|
PRKCA | P17252 | ARL6IP4 | Homo sapiens | Q66PJ3-4 | 32814053 | |
|
Intra
|
PRKCA | P17252 | ARL6IP4 | Homo sapiens | Q66PJ3-4 | 32814053 | |
|
Intra
|
PRKCA | P17252 | TCF4 | Homo sapiens | P15884 | 32814053 | |
|
Intra
|
PRKCA | P17252 | TCF4 | Homo sapiens | P15884 | 32814053 | |
|
Intra
|
PRKCA | P17252 | TCF4 | Homo sapiens | P15884 | 32814053 | |
|
Intra
|
PRKCA | P17252 | DRD1 | Homo sapiens | P21728 | 32814053 | |
|
Intra
|
PRKCA | P17252 | DRD1 | Homo sapiens | P21728 | 32814053 | |
|
Intra
|
PRKCA | P17252 | DRD1 | Homo sapiens | P21728 | 32814053 | |
|
Intra
|
PRKCA | P17252 | PRKCE | Homo sapiens | Q02156 | 31980649 | |
|
Intra
|
PRKCA | P17252 | IGFBP3 | Homo sapiens | P17936 | 32814053 | |
|
Intra
|
PRKCA | P17252 | IGFBP3 | Homo sapiens | P17936 | 32814053 | |
|
Intra
|
PRKCA | P17252 | IGFBP3 | Homo sapiens | P17936 | 32814053 | |
|
Intra
|
PRKCA | P17252 | CCDC47 | Homo sapiens | Q96A33 | 32814053 | |
|
Intra
|
PRKCA | P17252 | CCDC47 | Homo sapiens | Q96A33 | 32814053 | |
|
Intra
|
PRKCA | P17252 | CCDC47 | Homo sapiens | Q96A33 | 32814053 | |
|
Intra
|
PRKCA | P17252 | DEXI | Homo sapiens | O95424 | 32814053 | |
|
Intra
|
PRKCA | P17252 | DEXI | Homo sapiens | O95424 | 32814053 | |
|
Intra
|
PRKCA | P17252 | DEXI | Homo sapiens | O95424 | 32814053 | |
|
Intra
|
PRKCA | P17252 | LIPT1 | Homo sapiens | Q9Y234 | 32814053 | |
|
Intra
|
PRKCA | P17252 | LIPT1 | Homo sapiens | Q9Y234 | 32814053 | |
|
Intra
|
PRKCA | P17252 | LIPT1 | Homo sapiens | Q9Y234 | 32814053 | |
|
Intra
|
PRKCA | P17252 | NDUFV1 | Homo sapiens | P49821 | 32814053 | |
|
Intra
|
PRKCA | P17252 | NDUFV1 | Homo sapiens | P49821 | 32814053 | |
|
Intra
|
PRKCA | P17252 | NDUFV1 | Homo sapiens | P49821 | 32814053 | |
|
Intra
|
PRKCA | P17252 | DNPH1 | Homo sapiens | O43598 | 32814053 | |
|
Intra
|
PRKCA | P17252 | DNPH1 | Homo sapiens | O43598 | 32814053 | |
|
Intra
|
PRKCA | P17252 | DNPH1 | Homo sapiens | O43598 | 32814053 | |
|
Intra
|
PRKCA | P17252 | ZSCAN9 | Homo sapiens | O15535 | 32814053 | |
|
Intra
|
PRKCA | P17252 | ZSCAN9 | Homo sapiens | O15535 | 32814053 | |
|
Intra
|
PRKCA | P17252 | ZSCAN9 | Homo sapiens | O15535 | 32814053 | |
|
Intra
|
PRKCA | P17252 | ACAP1 | Homo sapiens | Q15027 | 32814053 | |
|
Intra
|
PRKCA | P17252 | ACAP1 | Homo sapiens | Q15027 | 32814053 | |
|
Intra
|
PRKCA | P17252 | ACAP1 | Homo sapiens | Q15027 | 32814053 | |
|
Intra
|
PRKCA | P17252 | SNCA | Homo sapiens | P37840 | 32814053 | |
|
Intra
|
PRKCA | P17252 | SNCA | Homo sapiens | P37840 | 32814053 | |
|
Intra
|
PRKCA | P17252 | SNCA | Homo sapiens | P37840 | 32814053 | |
|
Intra
|
PRKCA | P17252 | OXA1L | Homo sapiens | Q2M1J6 | 32814053 | |
|
Intra
|
PRKCA | P17252 | OXA1L | Homo sapiens | Q2M1J6 | 32814053 | |
|
Intra
|
PRKCA | P17252 | OXA1L | Homo sapiens | Q2M1J6 | 32814053 | |
|
Intra
|
PRKCA | P17252 | KRTAP3-1 | Homo sapiens | Q9BYR8 | 32814053 | |
|
Intra
|
PRKCA | P17252 | KRTAP3-1 | Homo sapiens | Q9BYR8 | 32814053 | |
|
Intra
|
PRKCA | P17252 | KRTAP3-1 | Homo sapiens | Q9BYR8 | 32814053 |
PRKCA Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80279 | Phospho-PKC alpha (T638) Antibody (YA163) | WB, ICC/IF, IHC-P, IP | Human, Mouse, Rat |
| HY-P80430 | PKC alpha Antibody (YA131) | WB, ICC/IF, IHC-P, FC, IP | Human, Mouse, Rat |
| HY-P810622 | Phospho-PKC alpha/beta II (Thr638/T641) Antibody (YA9884) | WB, IHC-P, ICC/IF, FC, Dot Blot | Human, Mouse, Rat |
| HY-P810623 | Phospho-PKC alpha (Thr497) Antibody (YA9885) | WB, ICC/IF, FC | Human, Mouse, Rat |
| HY-P81298 | Phospho-PKC alpha (Ser657) Antibody (YA1023) | WB, IHC-P | Human, Mouse, Rat |
| HY-P81298A | Phospho-PKC alpha (Thr638) Antibody (YA1024) | WB, IHC-P, IP | Human, Mouse, Rat |
| HY-P81298AA | Phospho-PKC alpha (Thr638) Antibody (YA1024)(PBS only) | WB, IHC-P, IP | Human, Mouse, Rat |
| HY-P81649 | Phospho-PKC (Ser660) Antibody (YA1394) | WB, IHC-P | Human, Rat |
| HY-P81649A | Phospho-PKC (Ser660) Antibody (YA1394)(PBS only) | WB, IHC-P | Human, Rat |
| HY-P85801 | PKC alpha Antibody (YA5493) | WB, ICC/IF, ELISA | Human, Mouse, Rat, Rabbit, Bovin |
| HY-P86142 | Phospho-PKC alpha(Thr638) Antibody (YA5834) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
| HY-P86233 | PKC alpha Antibody (YA5925) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Colorectal Cancer |
|
|
| Hepatocellular Carcinoma |
|
|
| Melanoma |
|
|
| Basal Cell Carcinoma |
|
|
| Thymoma |
|
|
| Lung Cancer |
|
|
| Breast Cancer |
|
|
| Multiple Sclerosis |
|
|
| Asbestos-Related Lung Carcinoma |
|
|
| Prostate Cancer |
|
|
| Nervous System Disease |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
| Ovarian Cancer |
|
|
| Dilated Cardiomyopathy |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Endometrial Cancer |
|
|
| Cystic Fibrosis |
|
|
| Congenital Stationary Night Blindness |
|
|
| Neural Tube Defects |
|
|
| Asthma |
|
|
| Hyperglycemia |
|
|
| Leber Plus Disease |
|
|
| Pancreatic Cancer |
|
|
| Glioblastoma |
|
|
| Retinitis Pigmentosa |
|
|
| Skin Disease |
|
|
| Chordoid Glioma |
|
|
| Neuroblastoma |
|
|
| Cone-Rod Dystrophy 2 |
|
|
| Hypertension, Essential |
|
|
| Heart Disease |
|
|
| Glioma |
|
|
| Eye Disease |
|
|
| Rhabdomyosarcoma |
|
|
| Cryptosporidiosis |
|
|
| Fundus Dystrophy |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | PRKCA | MGD | MGI:97595 |
| Macaca mulatta | PRKCA | VGNC | VGNC:76409 |
| Bos taurus | PRKCA | VGNC | VGNC:33327 |
| Felis catus | PRKCA | VGNC | VGNC:69055 |
| Rattus norvegicus | PRKCA | RGD | RGD:3395 |
| Canis familiaris | PRKCA | VGNC | VGNC:44978 |
| Others | PRKCA | NCBI |