MAP3K9 - mitogen-activated protein kinase kinase kinase 9 Gene

Also Known as MLK1; MEKK9; PRKE1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4293

About MAP3K9

Cytogenetic location: 14q24.2 Genomic coordinates (GRCh38): 14:70,722,526-70,809,513 (from NCBI)

This gene has 6 transcripts (splice variants), 194 orthologues and 23 paralogues. Broad expression in brain (RPKM 3.6), testis (RPKM 3.0) and 22 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in protein autophosphorylation. [provided by Alliance of Genome Resources, Apr 2022]

MAP3K9 Products (4)

mRNA Protein Name
NM_001284230.2 NP_001271159.1 mitogen-activated protein kinase kinase kinase 9 isoform 2
NM_001284231.1 NP_001271160.1 mitogen-activated protein kinase kinase kinase 9 isoform 3
NM_001284232.1 NP_001271161.1 mitogen-activated protein kinase kinase kinase 9 isoform 4
NM_033141.4 NP_149132.2 mitogen-activated protein kinase kinase kinase 9 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables molecular function activator activity EXP
EXP: Inferred from Experiment
18714982 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22939624 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
15610029 GOA
Biological Process GO Annotation Evidence References Source
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
15610029 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
15610029 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP3K9 Protein Structure

SH3_9

SH3_9: Variant SH3 domain (59 - 112)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (144 - 403)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1104 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase 9

  • mixed lineage kinase 1 (tyr and ser/thr specificity)

MAP3K9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MAP3K9 P80192 YWHAG Homo sapiens P61981
Validated Y2H
32814053
Intra
MAP3K9 P80192 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
Intra
MAP3K9 P80192 YWHAG Homo sapiens P61981
Y2H Array
32814053
Intra
MAP3K9 P80192 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
Intra
MAP3K9 P80192 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
Intra
MAP3K9 P80192 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Retroperitoneal Neuroblastoma
Retroperitoneum Carcinoma

  • Retroperitoneal Cancer

  • Malignant Neoplasm Of Retroperitoneum And Peritoneum

  • Retroperitoneal Neoplasms

  • Carcinoma Of Retroperitoneum

  • Carcinoma Of The Retroperitoneum

  • Malignant Neoplasm Of Retroperitoneum

  • Malignant Retroperitoneal Cancer

  • Malignant Tumor Of Peritoneum And Retroperitoneum

  • Neoplasm Of Retroperitoneum

  • Neoplasm Of The Retroperitoneum

  • Retroperitoneal Neoplasm

  • Tumor Of Retroperitoneum

  • Malignant Retroperitoneal Tumour

  • Primary Malignant Neoplasm Of Retroperitoneum

  • Retroperitoneum Cancer
Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia

  • Platelet Abnormalities With Eosinophilia And Immune-Mediated Inflammatory Disease

  • IMD71

  • Plteid

  • Immunodeficiency 71
Esophageal Cancer

  • Esophageal Carcinoma

  • Carcinoma Of Esophagus

  • Esophageal Squamous Cell Carcinoma, Somatic

  • Esophageal Carcinoma, Somatic

  • Esophagus Cancer

  • Gastric Cardia Adenocarcinoma

  • Esophageal Neoplasms

  • Esophageal Cancer, Somatic

  • Cancer Of Esophagus

  • Cancer Of Oesophagus

  • Carcinoma Of Oesophagus

  • Ca Lower Third Oesophagus

  • Ca Middle Third Oesophagus

  • Malignant Neoplasm Of Distal Third Of Esophagus

  • Malignant Neoplasm Of Lower Third Of Oesophagus

  • Malignant Neoplasm Of Middle Third Of Oesophagus

  • Malignant Neoplasm Of Proximal Third Of Esophagus

  • Malignant Neoplasm Of Upper Third Esophagus

  • Malignant Tumor Of Abdominal Esophagus

  • Malignant Tumor Of Distal Third Of Esophagus

  • Malignant Tumor Of Proximal Third Of Esophagus

  • Malignant Tumor Of The Middle Third Of The Esophagus

  • ESCR

  • Aerodigestive Tract Cancer

  • Escc

  • Esophageal Squamous Cell Carcinoma

  • Cancer, Esophageal

  • Malignant Neoplasm Of Esophagus

  • Squamous Cell Carcinoma Of Esophagus

  • Malignant Neoplasm Of Middle Third Of Esophagus
Ecthyma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08069 MAP3K9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20567 Map3k9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27076 Map3k9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MAP3K9 MGD MGI:2449952
Rattus norvegicus MAP3K9 RGD RGD:1562149
Canis familiaris MAP3K9 VGNC VGNC:42980
Bos taurus MAP3K9 VGNC VGNC:31203
Macaca mulatta MAP3K9 VGNC VGNC:74498
Others MAP3K9 NCBI