MAP3K9 - mitogen-activated protein kinase kinase kinase 9 Gene

Homo sapiens

Also known as MLK1; MEKK9; PRKE1

Gene ID: 4293 | Gene type: protein coding

About MAP3K9

Cytogenetic location: 14q24.2 Genomic coordinates (GRCh38): 14:70,722,526-70,809,513 (from NCBI)

This gene has 6 transcripts (splice variants), 194 orthologues and 23 paralogues. Broad expression in brain (RPKM 3.6), testis (RPKM 3.0) and 22 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in protein autophosphorylation. [provided by Alliance of Genome Resources, Apr 2022]

MAP3K9 Products(4)

mRNA	Protein	Name
NM_001284230.2	NP_001271159.1	mitogen-activated protein kinase kinase kinase 9 isoform 2
NM_001284231.1	NP_001271160.1	mitogen-activated protein kinase kinase kinase 9 isoform 3
NM_001284232.1	NP_001271161.1	mitogen-activated protein kinase kinase kinase 9 isoform 4
NM_033141.4	NP_149132.2	mitogen-activated protein kinase kinase kinase 9 isoform 1

MAP3K9 Protein Structure

SH3_9

Pkinase_Tyr

0
200
400
600
800
1000
1104 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase kinase kinase 9

mixed lineage kinase 1 (tyr and ser/thr specificity)

Related Diseases

Diseases

Alias

Retroperitoneal Neuroblastoma

Retroperitoneum Carcinoma

Retroperitoneal Cancer	Malignant Neoplasm Of Retroperitoneum And Peritoneum
Retroperitoneal Neoplasms	Carcinoma Of Retroperitoneum
Carcinoma Of The Retroperitoneum	Malignant Neoplasm Of Retroperitoneum
Malignant Retroperitoneal Cancer	Malignant Tumor Of Peritoneum And Retroperitoneum
Neoplasm Of Retroperitoneum	Neoplasm Of The Retroperitoneum
Retroperitoneal Neoplasm	Tumor Of Retroperitoneum
Malignant Retroperitoneal Tumour	Primary Malignant Neoplasm Of Retroperitoneum
Retroperitoneum Cancer

Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia

Platelet Abnormalities With Eosinophilia And Immune-Mediated Inflammatory Disease	IMD71
Plteid	Immunodeficiency 71

Esophageal Cancer

Esophageal Carcinoma	Carcinoma Of Esophagus
Esophageal Squamous Cell Carcinoma, Somatic	Esophageal Carcinoma, Somatic
Esophagus Cancer	Gastric Cardia Adenocarcinoma
Esophageal Neoplasms	Esophageal Cancer, Somatic
Cancer Of Esophagus	Cancer Of Oesophagus
Carcinoma Of Oesophagus	Ca Lower Third Oesophagus
Ca Middle Third Oesophagus	Malignant Neoplasm Of Distal Third Of Esophagus
Malignant Neoplasm Of Lower Third Of Oesophagus	Malignant Neoplasm Of Middle Third Of Oesophagus
Malignant Neoplasm Of Proximal Third Of Esophagus	Malignant Neoplasm Of Upper Third Esophagus
Malignant Tumor Of Abdominal Esophagus	Malignant Tumor Of Distal Third Of Esophagus
Malignant Tumor Of Proximal Third Of Esophagus	Malignant Tumor Of The Middle Third Of The Esophagus
ESCR	Aerodigestive Tract Cancer
Escc	Esophageal Squamous Cell Carcinoma
Cancer, Esophageal	Malignant Neoplasm Of Esophagus
Squamous Cell Carcinoma Of Esophagus	Malignant Neoplasm Of Middle Third Of Esophagus

Ecthyma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08069	MAP3K9 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MAP3K9	MGD	MGI:2449952
Rattus norvegicus	MAP3K9	RGD	RGD:1562149
Canis familiaris	MAP3K9	VGNC	VGNC:42980
Bos taurus	MAP3K9	VGNC	VGNC:31203
Macaca mulatta	MAP3K9	VGNC	VGNC:74498

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