EIF3E - eukaryotic translation initiation factor 3 subunit E Gene

Also Known as INT6; EIF3S6; EIF3-P48; eIF3-p46

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3646

About EIF3E

Cytogenetic location: 8q23.1 Genomic coordinates (GRCh38): 8:108,201,216-108,248,717 (from NCBI)

This gene has 57 transcripts (splice variants), 234 orthologues and is associated with 57 phenotypes. Ubiquitous expression in ovary (RPKM 226.7), lymph node (RPKM 138.2) and 25 other tissues.

Summary

Enables protein N-terminus binding activity. Contributes to translation initiation factor activity. Involved in positive regulation of mRNA binding activity; regulation of gene expression; and translational initiation. Located in cytosol and nucleus. Part of eukaryotic translation initiation factor 3 complex. Colocalizes with PML body. [provided by Alliance of Genome Resources, Apr 2022]

EIF3E Products (1)

mRNA Protein Name
NM_001568.3 NP_001559.1 eukaryotic translation initiation factor 3 subunit E

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10504338 GOA
contributes to translation initiation factor activity IDA
IDA: Inferred from direct assay
17581632 GOA
Biological Process GO Annotation Evidence References Source
involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
IMP: Inferred from mutant phenotype
17468741 GOA
involved in positive regulation of mRNA binding IPI
IPI: Inferred from physical interaction
24092755 GOA
involved in positive regulation of translation IPI
IPI: Inferred from physical interaction
24092755 GOA
involved in translational initiation IDA
IDA: Inferred from direct assay
17581632 GOA
Cellular Component GO Annotation Evidence References Source
colocalizes with PML body IDA
IDA: Inferred from direct assay
10504338 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
10504338 GOA
part of eukaryotic translation initiation factor 3 complex IDA
IDA: Inferred from direct assay
9295280 GOA
part of eukaryotic translation initiation factor 3 complex IPI
IPI: Inferred from physical interaction
17322308 GOA
located in nucleus IDA
IDA: Inferred from direct assay
10504338 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF3E Protein Structure

eIF3_N

eIF3_N: eIF3 subunit 6 N terminal domain (5 - 138)

PCI

PCI: PCI domain (292 - 394)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 445 a.a.
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 3 subunit E

  • eIF-3 p48

EIF3E Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EIF3E P60228 C4orf19 Homo sapiens Q8IY42
Y2H Array
31515488
Intra
EIF3E P60228 C4orf19 Homo sapiens Q8IY42
Validated Y2H
25416956
Intra
EIF3E P60228 C4orf19 Homo sapiens Q8IY42
Y2H Array
25416956
Intra
EIF3E P60228 ISCA2 Homo sapiens Q86U28
Y2H Prey Pooling
32296183
Intra
EIF3E P60228 ISCA2 Homo sapiens Q86U28
Validated Y2H
32296183
Intra
EIF3E P60228 ISCA2 Homo sapiens Q86U28
Y2H Array
32296183
Intra
EIF3E P60228 KPRP Homo sapiens Q5T749
Validated Y2H
32296183
Intra
EIF3E P60228 KPRP Homo sapiens Q5T749
Y2H Array
32296183
Intra
EIF3E P60228 KPRP Homo sapiens Q5T749
Y2H Prey Pooling
32296183
Intra
EIF3E P60228 RUNDC3A Homo sapiens Q59EK9-3
Y2H Prey Pooling
32296183
Intra
EIF3E P60228 RUNDC3A Homo sapiens Q59EK9-3
Validated Y2H
32296183
Intra
EIF3E P60228 RUNDC3A Homo sapiens Q59EK9-3
Y2H Array
32296183
Intra
EIF3E P60228 ZNF48 Homo sapiens Q96MX3
Validated Y2H
32296183
Intra
EIF3E P60228 ZNF48 Homo sapiens Q96MX3
Y2H Prey Pooling
32296183
Intra
EIF3E P60228 ZNF48 Homo sapiens Q96MX3
Y2H Array
32296183
Intra
EIF3E P60228 EPN2 Homo sapiens O95208-2
Y2H Prey Pooling
32296183
Intra
EIF3E P60228 EPN2 Homo sapiens O95208-2
Y2H Array
32296183
Intra
EIF3E P60228 CD74 Homo sapiens P04233
Pull Down
30833792
Intra
EIF3E P60228 MIIP Homo sapiens Q5JXC2
Y2H Prey Pooling
32296183
Intra
EIF3E P60228 MIIP Homo sapiens Q5JXC2
Validated Y2H
32296183
Intra
EIF3E P60228 MIIP Homo sapiens Q5JXC2
Y2H Array
32296183
Intra
EIF3E P60228 DDX60 Homo sapiens Q8IY21
Pull Down
30833792
Intra
EIF3E P60228 MRNIP Homo sapiens Q6NTE8
Y2H Prey Pooling
32296183
Intra
EIF3E P60228 MRNIP Homo sapiens Q6NTE8
Validated Y2H
32296183
Intra
EIF3E P60228 MRNIP Homo sapiens Q6NTE8
Y2H Array
32296183
Intra
EIF3E P60228 EIF3C Homo sapiens Q99613
Y2H
10504338
Intra
EIF3E P60228 EIF3C Homo sapiens Q99613
Pull Down
23623729
Intra
EIF3E P60228 EIF3C Homo sapiens Q99613
Anti Tag CoIP
28514442
Intra
EIF3E P60228 EIF3D Homo sapiens O15371
Anti Bait CoIP
20890303
Intra
EIF3E P60228 EIF3D Homo sapiens O15371
Anti Tag CoIP
33961781
Intra
EIF3E P60228 EIF3D Homo sapiens O15371
Anti Tag CoIP
28514442
Intra
EIF3E P60228 EIF3K Homo sapiens Q9UBQ5
Anti Tag CoIP
28514442
Intra
EIF3E P60228 EIF3K Homo sapiens Q9UBQ5
Anti Tag CoIP
18599441
Intra
EIF3E P60228 EIF3K Homo sapiens Q9UBQ5
SLCA
19748344
Intra
EIF3E P60228 EIF3K Homo sapiens Q9UBQ5
Pull Down
23623729
Intra
EIF3E P60228 EIF3K Homo sapiens Q9UBQ5
SLCA
18599441
Intra
EIF3E P60228 EIF3K Homo sapiens Q9UBQ5
Anti Tag CoIP
33961781
Intra
EIF3E P60228 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
Intra
EIF3E P60228 YWHAG Homo sapiens P61981
Validated Y2H
32814053
Intra
EIF3E P60228 YWHAG Homo sapiens P61981
Y2H Array
32814053
Intra
EIF3E P60228 EIF3A Homo sapiens Q14152
Anti Tag CoIP
33961781
Intra
EIF3E P60228 EIF3A Homo sapiens Q14152
Anti Tag CoIP
28514442
Intra
EIF3E P60228 EIF3A Homo sapiens Q14152
Anti Tag CoIP
35271311
Intra
EIF3E P60228 EIF3A Homo sapiens Q14152
Pull Down
23623729
Intra
EIF3E P60228 EIF3B Homo sapiens P55884
Anti Tag CoIP
33961781
Intra
EIF3E P60228 EIF3L Homo sapiens Q9Y262
Pull Down
23623729
Intra
EIF3E P60228 EIF3L Homo sapiens Q9Y262
SLCA
19748344
Intra
EIF3E P60228 EIF3L Homo sapiens Q9Y262
SLCA
18599441
Intra
EIF3E P60228 EIF3L Homo sapiens Q9Y262
Anti Tag CoIP
33961781
Intra
EIF3E P60228 EIF3L Homo sapiens Q9Y262
Anti Tag CoIP
28514442
Intra
EIF3E P60228 EPAS1 Homo sapiens Q99814
Anti Bait CoIP
17324924
Intra
EIF3E P60228 EPAS1 Homo sapiens Q99814
Y2H
17324924
Intra
EIF3E P60228 ZDHHC17 Homo sapiens Q8IUH5
Lumier
24705354
Cross
EIF3E P60228 ORF Human immunodeficiency virus Q9Q2G4
Pull Down
22190034
Intra
EIF3E P60228 TRIM27 Homo sapiens P14373
Confocal
10504338
Intra
EIF3E P60228 TRIM27 Homo sapiens P14373
Y2H
10504338
Intra
EIF3E P60228 TRIM27 Homo sapiens P14373
Anti Tag CoIP
10504338
Intra
EIF3E P60228 GPBP1L1 Homo sapiens Q9HC44
Y2H Pooling
16189514
Intra
EIF3E P60228 RUNDC3A Homo sapiens Q59EK9
Y2H Prey Pooling
25416956
Intra
EIF3E P60228 RUNDC3A Homo sapiens Q59EK9
Y2H Pooling
16189514
Intra
EIF3E P60228 RUNDC3A Homo sapiens Q59EK9
Validated Y2H
25416956
Intra
EIF3E P60228 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
Intra
EIF3E P60228 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
Intra
EIF3E P60228 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

EIF3E Antibodies

Cat. No. Product Name Application Reactivity
HY-P83081 eIF3E Antibody (YA2826) WB, ICC/IF Human, Mouse, Rat
HY-P83081A eIF3E Antibody (YA2826)(PBS only) WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-180490 eIF3e-IN-1 Inhibitor / Unkown
HY-RS04261 EIF3E Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus EIF3E RGD RGD:1311521
Felis catus EIF3E VGNC VGNC:81650
Canis familiaris EIF3E VGNC VGNC:40271
Macaca mulatta EIF3E VGNC VGNC:83997
Mus musculus EIF3E MGD MGI:99257
Bos taurus EIF3E VGNC VGNC:28395
Others EIF3E NCBI