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DDX60 - DExD/H-box helicase 60 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55601

About DDX60

Cytogenetic location: 4q32.3 Genomic coordinates (GRCh38): 4:168,216,294-168,325,979 (from NCBI)

This gene has 12 transcripts (splice variants), 114 orthologues and 8 paralogues. Ubiquitous expression in stomach (RPKM 14.0), colon (RPKM 7.7) and 24 other tissues.

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular procsses involving RNA binding and alteration of RNA secondary structure. This gene encodes a DEXD/H box RNA helicase that functions as an Antiviral factor and promotes RIG-I-like receptor-mediated signaling. [provided by RefSeq, Apr 2017]

DDX60 Products (2)

mRNA	Protein	Name
NM_001410861.1	NP_001397790.1	probable ATP-dependent RNA helicase DDX60 isoform 2
NM_017631.6	NP_060101.3	probable ATP-dependent RNA helicase DDX60 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	21791617	GOA
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	21791617	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21791617	GOA
enables single-stranded RNA binding	IDA IDA: Inferred from direct assay	21791617	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of MDA-5 signaling pathway	IMP IMP: Inferred from mutant phenotype	21791617	GOA
involved in positive regulation of RIG-I signaling pathway	IMP IMP: Inferred from mutant phenotype	21791617	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	21791617	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21791617	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDX60 Protein Structure

DEAD

Helicase_C

0
300
600
900
1200
1500
1712 a.a.

Protein Preferred Names	Protein Names
probable ATP-dependent RNA helicase DDX60	ATP-dependent RNA helicase DDX60

DDX60 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DDX60	Q8IY21	EIF3E	Homo sapiens	P60228	Pull Down	30833792

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Plantar Wart	Verruca Plantaris Verrucae On Sole Of Foot Mosaic Plantar Warts
Lip Cancer	Malignant Neoplasm Of Lip Malignant Neoplasm Of Oral Aspect Of Lip, Not Specified Whether Upper Or Lower Malignant Tumour Of Lip Lip Neoplasms Malignant Neoplasm Of Commissure Of Lip Malignant Neoplasm Of External Lip, Not Specified As Upper Or Lower Malignant Neoplasm Of Labial Commissure Of Lip Malignant Neoplasm Of Lip, External Malignant Neoplasm Of Lip, Inner Aspect Malignant Neoplasm Of Lip, Vermilion Border Malignant Neoplasm Of Lower Lip, Buccal Aspect Malignant Neoplasm Of Lower Lip, Inner Aspect Malignant Neoplasm Of Lower Lip, Mucosa Malignant Neoplasm Of Lower Lip, Oral Aspect Malignant Neoplasm Of Other Sites Of Lip Malignant Neoplasm Of Vermilion Border Of Lip Malignant Tumor Of Commissure Of Lip Malignant Tumor Of Labial Mucosa Malignant Tumor Of Lip Malignant Tumor Of Lower Labial Mucosa Malignant Tumor Of The Lip Malignant Tumour Of Labial Commissure Cancer Of Lip Primary Malignant Neoplasm Of Vermilion Border Of Upper Lip Upper Lip Cancer Lower Lip Cancer Primary Malignant Neoplasm Of Vermilion Border Of Lower Lip Primary Malignant Neoplasm Of Vermilion Border Of Lip Malignant Neoplasm Of Lipstick Area Of Upper Lip Malignant Neoplasm Of Upper Lip Nos Malignant Neoplasm Of Vermilion Border Of Upper Lip Malignant Neoplasm Of Lipstick Area Of Lower Lip Malignant Neoplasm Of Lower Lip Nos Malignant Neoplasm Of Vermilion Border Of Lower Lip Malignant Neoplasm Of Vermilion Border Nos Malignant Neoplasm Of Buccal Aspect Of Upper Lip Malignant Neoplasm Of Frenulum Of Upper Lip Malignant Neoplasm Of Mucosa Of Upper Lip Malignant Neoplasm Of Oral Aspect Of Upper Lip Malignant Neoplasm Of Buccal Aspect Of Lower Lip Malignant Neoplasm Of Frenulum Of Lower Lip Malignant Neoplasm Of Mucosa Of Lower Lip Malignant Neoplasm Of Oral Aspect Of Lower Lip Malignant Neoplasm Of Buccal Aspect Of Lip, Not Specified Whether Upper Or Lower Malignant Neoplasm Of Frenulum Of Lip, Not Specified Whether Upper Or Lower Malignant Neoplasm Of Mucosa Of Lip, Not Specified Whether Upper Or Lower Primary Malignant Neoplasm Of Commissure Of Lip Primary Malignant Neoplasm Of Lip Malignant Neoplasm Of Lip, Unspecified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03664	DDX60 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03665	DDX60L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21550	Ddx60 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28068	Ddx60 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DDX60	VGNC	VGNC:71711
Mus musculus	DDX60	MGD	MGI:2384570
Rattus norvegicus	DDX60	RGD	RGD:1560014
Canis familiaris	DDX60	VGNC	VGNC:54938
Felis catus	DDX60	VGNC	VGNC:61421
Others	DDX60	NCBI