2. Gene
  3. EIF3D - eukaryotic translation initiation factor 3 subunit D Gene

EIF3D - eukaryotic translation initiation factor 3 subunit D Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as EIF3S7; eIF3-p66; eIF3-zeta

Gene ID: 8664 | Gene type: protein coding

About EIF3D

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:36,510,855-36,529,166 (from NCBI)

This gene has 12 transcripts (splice variants) and 223 orthologues. Ubiquitous expression in ovary (RPKM 83.0), lymph node (RPKM 75.1) and 25 other tissues.

Summary

Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex. [provided by RefSeq, Jul 2008]

EIF3D Products(1)

mRNA Protein Name
NM_003753.4 NP_003744.1 eukaryotic translation initiation factor 3 subunit D

EIF3D Protein Structure

eIF-3_zeta

eIF-3_zeta: Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) (3 - 521)

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  • 548 a.a.
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 3 subunit D

eIF3 p66

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04260 EIF3D Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus EIF3D MGD MGI:1933181
Canis familiaris EIF3D VGNC VGNC:40270
Bos taurus EIF3D VGNC VGNC:28394
Felis catus EIF3D VGNC VGNC:61782
Macaca mulatta EIF3D VGNC VGNC:72192
Rattus norvegicus EIF3D RGD RGD:1303255