DVL3 - dishevelled segment polarity protein 3 Gene
Also Known as DRS3
Species: Homo sapiens
About DVL3
This gene has 11 transcripts (splice variants), 273 orthologues, 3 paralogues and is associated with 3 phenotypes. Ubiquitous expression in placenta (RPKM 25.5), endometrium (RPKM 18.5) and 25 other tissues.
Summary
This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [provided by RefSeq, Jul 2008]
DVL3 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_004423.4 | NP_004414.3 | segment polarity protein dishevelled homolog DVL-3 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables beta-catenin binding |
IDA
IDA: Inferred from direct assay
|
10644691 | GOA |
| enables frizzled binding |
IPI
IPI: Inferred from physical interaction
|
19388021 | GOA |
| enables protease binding |
IPI
IPI: Inferred from physical interaction
|
20227366 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
10330181 | GOA |
| enables signaling receptor binding |
IPI
IPI: Inferred from physical interaction
|
17030191 | GOA |
| enables small GTPase binding |
IPI
IPI: Inferred from physical interaction
|
23109420 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in chromatin |
IDA
IDA: Inferred from direct assay
|
21880741 | GOA |
| located in cytosol |
IDA
IDA: Inferred from direct assay
|
23109420 | GOA |
DVL3 Protein Structure
DIX: DIX domain (2 - 81)
Dishevelled: Dishevelled specific domain (142 - 213)
PDZ: PDZ domain (Also known as DHR or GLGF) (250 - 333)
DEP: Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) (425 - 494)
Dsh_C: Segment polarity protein dishevelled (Dsh) C terminal (500 - 706)
- 0
- 200
- 400
- 600
- 716 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
segment polarity protein dishevelled homolog DVL-3 |
|
DVL3 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
DVL3 | Q92997 | ZSCAN22 | Homo sapiens | P10073 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ZSCAN22 | Homo sapiens | P10073 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | BEND7 | Homo sapiens | Q8N7W2-2 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | BEND7 | Homo sapiens | Q8N7W2-2 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | LUZP4 | Homo sapiens | Q9P127 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | LUZP4 | Homo sapiens | Q9P127 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | LUZP4 | Homo sapiens | Q9P127 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ZNF699 | Homo sapiens | Q32M78 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ZNF699 | Homo sapiens | Q32M78 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | SYT6 | Homo sapiens | Q5T7P8-2 | 25416956 | |
|
Intra
|
DVL3 | Q92997 | ZNF774 | Homo sapiens | Q6NX45 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ZNF774 | Homo sapiens | Q6NX45 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ZNF697 | Homo sapiens | Q8N508 | 25416956 | |
|
Intra
|
DVL3 | Q92997 | ZNF697 | Homo sapiens | Q8N508 | 25416956 | |
|
Intra
|
DVL3 | Q92997 | ZSCAN21 | Homo sapiens | Q9Y5A6 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | PPP1R16B | Homo sapiens | Q96T49 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | PPP1R16B | Homo sapiens | Q96T49 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | PPP1R16B | Homo sapiens | Q96T49 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | TSN | Homo sapiens | Q15631 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | TSN | Homo sapiens | Q15631 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | PNKP | Homo sapiens | Q96T60 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | JPH3 | Homo sapiens | Q8WXH2 | 32814053 | |
|
Intra
|
DVL3 | Q92997 | JPH3 | Homo sapiens | Q8WXH2 | 32814053 | |
|
Intra
|
DVL3 | Q92997 | JPH3 | Homo sapiens | Q8WXH2 | 32814053 | |
|
Intra
|
DVL3 | Q92997 | PATZ1 | Homo sapiens | Q9HBE1-4 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | PATZ1 | Homo sapiens | Q9HBE1-4 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | PATZ1 | Homo sapiens | Q9HBE1-4 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | NFYA | Homo sapiens | P23511-2 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | NFYA | Homo sapiens | P23511-2 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ZNF696 | Homo sapiens | Q9H7X3 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | FLACC1 | Homo sapiens | Q96Q35-2 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | FLACC1 | Homo sapiens | Q96Q35-2 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | FLACC1 | Homo sapiens | Q96Q35-2 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | TLE5 | Homo sapiens | Q08117-2 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | TLE5 | Homo sapiens | Q08117-2 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | KCTD7 | Homo sapiens | Q96MP8-2 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | KCTD7 | Homo sapiens | Q96MP8-2 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | KCTD7 | Homo sapiens | Q96MP8-2 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | SHFL | Homo sapiens | Q9NUL5-4 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ZNF837 | Homo sapiens | Q96EG3 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ZNF319 | Homo sapiens | Q9P2F9 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | TSPYL6 | Homo sapiens | Q8N831 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | TSPYL6 | Homo sapiens | Q8N831 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ANKRD36B | Homo sapiens | Q8N2N9-4 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | SNX22 | Homo sapiens | Q96L94-2 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ZFP57 | Homo sapiens | Q9NU63-3 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ZFP57 | Homo sapiens | Q9NU63-3 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ZFP57 | Homo sapiens | Q9NU63-3 | 32296183 | |
|
Cross
|
DVL3 | Q92997 | Dab2 | Mus musculus | P98078 | 12805222 | |
|
Intra
|
DVL3 | Q92997 | NKD1 | Homo sapiens | Q969G9 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ZNF441 | Homo sapiens | Q8N8Z8 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ZNF441 | Homo sapiens | Q8N8Z8 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | WT1 | Homo sapiens | P19544 | 21900206 | |
|
Intra
|
DVL3 | Q92997 | WT1 | Homo sapiens | P19544 | 27229929 | |
|
Intra
|
DVL3 | Q92997 | SAP30L | Homo sapiens | Q9HAJ7 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | AP3M1 | Homo sapiens | Q9Y2T2 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | KCTD10 | Homo sapiens | Q9H3F6 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | KCTD10 | Homo sapiens | Q9H3F6 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | KCTD10 | Homo sapiens | Q9H3F6 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ZNF552 | Homo sapiens | Q9H707 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ZNF552 | Homo sapiens | Q9H707 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ZNF552 | Homo sapiens | Q9H707 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ABT1 | Homo sapiens | Q9ULW3 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | KLF15 | Homo sapiens | Q9UIH9 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | KLF15 | Homo sapiens | Q9UIH9 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | KLF15 | Homo sapiens | Q9UIH9 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | PRPF18 | Homo sapiens | Q99633 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ZNF264 | Homo sapiens | Q14C61 | 25416956 | |
|
Intra
|
DVL3 | Q92997 | ZNF264 | Homo sapiens | Q14C61 | 25416956 | |
|
Intra
|
DVL3 | Q92997 | CCNL1 | Homo sapiens | Q9UK58 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | YTHDC1 | Homo sapiens | Q96MU7 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | PLAGL2 | Homo sapiens | Q9UPG8 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | PLAGL2 | Homo sapiens | Q9UPG8 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | PLAGL2 | Homo sapiens | Q9UPG8 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ZNF408 | Homo sapiens | Q9H9D4 | 16189514 | |
|
Intra
|
DVL3 | Q92997 | ZNF408 | Homo sapiens | Q9H9D4 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | CSNK2A1 | Homo sapiens | P68400 | 33961781 | |
|
Intra
|
DVL3 | Q92997 | CSNK2A1 | Homo sapiens | P68400 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | CSNK2A1 | Homo sapiens | P68400 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | CSNK2A1 | Homo sapiens | P68400 | 28514442 | |
|
Intra
|
DVL3 | Q92997 | PSME3 | Homo sapiens | P61289 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | PSME3 | Homo sapiens | P61289 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | TRAF2 | Homo sapiens | Q12933 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | TRAF2 | Homo sapiens | Q12933 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ZBTB26 | Homo sapiens | Q9HCK0 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ZBTB26 | Homo sapiens | Q9HCK0 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ZBTB26 | Homo sapiens | Q9HCK0 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | CEP164 | Homo sapiens | Q9UPV0 | 22863007 | |
|
Intra
|
DVL3 | Q92997 | CEP164 | Homo sapiens | Q9UPV0 | 22863007 | |
|
Intra
|
DVL3 | Q92997 | NXF1 | Homo sapiens | Q9UBU9 | 25416956 | |
|
Intra
|
DVL3 | Q92997 | NXF1 | Homo sapiens | Q9UBU9 | 25416956 | |
|
Intra
|
DVL3 | Q92997 | NXF1 | Homo sapiens | Q9UBU9 | 25416956 | |
|
Intra
|
DVL3 | Q92997 | LRRK2 | Homo sapiens | Q5S007 | 19625296 | |
|
Intra
|
DVL3 | Q92997 | BHLHE40 | Homo sapiens | O14503 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | BHLHE40 | Homo sapiens | O14503 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | CBX8 | Homo sapiens | Q9HC52 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ZNF71 | Homo sapiens | Q9NQZ8 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | UTP3 | Homo sapiens | Q9NQZ2 | 25416956 | |
|
Intra
|
DVL3 | Q92997 | ADAP1 | Homo sapiens | O75689 | 25416956 | |
|
Intra
|
DVL3 | Q92997 | ADAP1 | Homo sapiens | O75689 | 25416956 | |
|
Intra
|
DVL3 | Q92997 | ZNF775 | Homo sapiens | Q96BV0 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | INO80B | Homo sapiens | Q9C086 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | NOL12 | Homo sapiens | Q9UGY1 | 25416956 | |
|
Intra
|
DVL3 | Q92997 | NOL12 | Homo sapiens | Q9UGY1 | 25416956 | |
|
Intra
|
DVL3 | Q92997 | WFS1 | Homo sapiens | O76024 | 32814053 | |
|
Intra
|
DVL3 | Q92997 | WFS1 | Homo sapiens | O76024 | 32814053 | |
|
Intra
|
DVL3 | Q92997 | WFS1 | Homo sapiens | O76024 | 32814053 | |
|
Intra
|
DVL3 | Q92997 | KLF4 | Homo sapiens | O43474 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | KLF4 | Homo sapiens | O43474 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | DVL1 | Homo sapiens | O14640 | 10330181 | |
|
Intra
|
DVL3 | Q92997 | LENG8 | Homo sapiens | Q96PV6 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | CEP70 | Homo sapiens | Q8NHQ1 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | CEP70 | Homo sapiens | Q8NHQ1 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | PRR13 | Homo sapiens | Q9NZ81 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | KLHL12 | Homo sapiens | Q53G59 | 16189514 | |
|
Intra
|
DVL3 | Q92997 | KLHL12 | Homo sapiens | Q53G59 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | KLHL12 | Homo sapiens | Q53G59 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | SORBS3 | Homo sapiens | O60504 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | SORBS3 | Homo sapiens | O60504 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | THAP7 | Homo sapiens | Q9BT49 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | MMTAG2 | Homo sapiens | Q9BU76 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ZBTB8A | Homo sapiens | Q96BR9 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ZBTB8A | Homo sapiens | Q96BR9 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ZBTB8A | Homo sapiens | Q96BR9 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | BAHD1 | Homo sapiens | Q8TBE0 | 16189514 | |
|
Intra
|
DVL3 | Q92997 | CEP76 | Homo sapiens | Q8TAP6 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | CEP76 | Homo sapiens | Q8TAP6 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | PRPF3 | Homo sapiens | O43395 | 16189514 | |
|
Intra
|
DVL3 | Q92997 | ZBTB48 | Homo sapiens | P10074 | 16189514 | |
|
Intra
|
DVL3 | Q92997 | ZNF581 | Homo sapiens | Q9P0T4 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ZNF764 | Homo sapiens | Q96H86 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | MAGOHB | Homo sapiens | Q96A72 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | SYTL4 | Homo sapiens | Q96C24 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | SYTL4 | Homo sapiens | Q96C24 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | PITX1 | Homo sapiens | P78337 | 16189514 | |
|
Intra
|
DVL3 | Q92997 | HOMER3 | Homo sapiens | Q9NSC5 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | HOMER3 | Homo sapiens | Q9NSC5 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | HOMER3 | Homo sapiens | Q9NSC5 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | PRPS1 | Homo sapiens | P60891 | 32814053 | |
|
Intra
|
DVL3 | Q92997 | PRPS1 | Homo sapiens | P60891 | 32814053 | |
|
Intra
|
DVL3 | Q92997 | PRPS1 | Homo sapiens | P60891 | 32814053 | |
|
Intra
|
DVL3 | Q92997 | CSNK1E | Homo sapiens | P49674 | 25416956 | |
|
Intra
|
DVL3 | Q92997 | CSNK1E | Homo sapiens | P49674 | 25416956 | |
|
Intra
|
DVL3 | Q92997 | FAM13C | Homo sapiens | Q8NE31 | 25416956 | |
|
Intra
|
DVL3 | Q92997 | CSNK1D | Homo sapiens | P48730 | 25416956 | |
|
Intra
|
DVL3 | Q92997 | TNFAIP8L1 | Homo sapiens | Q8WVP5 | 16189514 | |
|
Intra
|
DVL3 | Q92997 | ZBTB47 | Homo sapiens | Q9UFB7 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | KLF1 | Homo sapiens | Q13351 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | KLF1 | Homo sapiens | Q13351 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | CDYL2 | Homo sapiens | Q8N8U2 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | CDYL2 | Homo sapiens | Q8N8U2 | 32296183 | |
|
Intra
|
DVL3 | Q92997 | ZNF2 | Homo sapiens | Q9BSG1 | 32296183 |
DVL3 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P810869 | Dishevelled 3 Antibody | WB, IHC-P | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Robinow Syndrome, Autosomal Dominant 3 |
|
|
| Autosomal Dominant Robinow Syndrome |
|
|
| Robinow Syndrome, Autosomal Dominant 1 |
|
|
| Robinow Syndrome |
|
|
| Robinow Syndrome, Autosomal Recessive 1 |
|
|
| Robinow Syndrome, Autosomal Dominant 2 |
|
|
| Neural Tube Defects |
|
|
| Omodysplasia 2 |
|
|
| Brachydactyly, Type B1 |
|
|
| Omodysplasia 1 |
|
|
| Omodysplasia |
|
|
| Myelomeningocele |
|
|
| Colorectal Cancer |
|
|
| Hepatocellular Carcinoma |
|
|
| Anencephaly |
|
|
| Strabismus |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | DVL3 | VGNC | VGNC:97405 |
| Rattus norvegicus | DVL3 | RGD | RGD:1308834 |
| Mus musculus | DVL3 | MGD | MGI:108100 |
| Macaca mulatta | DVL3 | VGNC | VGNC:72014 |
| Bos taurus | DVL3 | VGNC | VGNC:28266 |
| Canis familiaris | DVL3 | VGNC | VGNC:40139 |
| Others | DVL3 | NCBI |