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54458

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14

Inhibitors & Agonists

1

Inhibitory Antibodies

3

Recombinant Proteins

1

Isotope-Labeled Compounds

13

Antibodies

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-164835
    VcMMAE-Deruxtecan

    SMP-54418

    		 Drug-Linker Conjugates for ADC Microtubule/Tubulin Topoisomerase Cancer
    VcMMAE-Deruxtecan (SMP-54418) is a Drug-Linker Conjugates for ADC, which is composed of a linker and a toxic molecule MMAE (HY-15162) (Microtubule inhibitor) and Exatecan (HY-13631) (DNA topoisomerase I inhibitor). VcMMAE-Deruxtecan can be used for ADC synthesis.
    VcMMAE-Deruxtecan
  • HY-P9989
    Linvoseltamab

    REGN5458

    		 CD3 TNF Receptor Cancer
    Linvoseltamab (REGN5458) is a bispecific T-cell engager (BiTE) antibody that specifically binds to B cell maturation antigen (BCMA) and CD3 of T cells, thereby directing T cells to multiple myeloma (MM) cells expressing BCMA and activating T cells to kill tumor cells. Linvoseltamab can be used in research of relapsed/refractory multiple myeloma (RRMM) .
    Linvoseltamab
  • HY-101432
    Fenclozic acid

    ICI-54450; Acidum fenclozicum; Mialex

    		 COX Inflammation/Immunology
    Fenclozic acid (ICI-54450) is an orally active anti-inflammatory, analgesic, and antipyretic agent. Fenclozic acid exhibits anti-inflammatory activity in Edadjuvant-induced arthritis and Carrageenin-induced oedema in rats. Fenclozic acid can be used for the research of arthritis .
    Fenclozic acid
  • HY-B0878
    Halobetasol propionate
    1 Publications Verification

    BMY-30056; CGP-14458; Ulobetasol propionate

    		 Glucocorticoid Receptor Inflammation/Immunology
    Halobetasol propionate (BMY-30056) is a synthetic glucocorticoid corticosteroid. Halobetasol propionate exhibits anti-inflammatory, antipruritic, and vasoconstrictive properties. Halobetasol propionate can be used for the study of psoriasis .
    Halobetasol propionate
  • HY-100933
    MY-5445
    1 Publications Verification

    		 Phosphodiesterase (PDE) Cardiovascular Disease Inflammation/Immunology Cancer
    MY-5445 is a specific inhibitor of the cyclic GMP phosphodiesterase, phosphodiesterase type 5 (PDE5), with a Ki of 1.3 μM. MY-5445 inhibits human platelet aggregation. MY-5445 is a selective modulator of ATP-binding cassette (ABC) transporter ABCG2, with anti-proliferative effect .
    MY-5445
  • HY-R01064
    hsa-miR-4458 mimic

    		MicroRNA Cancer
    hsa-miR-4458 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    hsa-miR-4458 mimic
    hsa-miR-4458 mimic
  • HY-A0224
    Forasartan

    SC-52458

    		 Angiotensin Receptor Cardiovascular Disease
    Forasartan is an nonpeptide angiotensin AT1 receptor antagonist with an IC50 of 2.9 nM. Forasartan is also an anti-hypertension agent. Forasartan significantly inhibits preganglionic stimulation in a dose-dependent manner in vivo. Forasartan can inhibit the heart rate increase induced by angiotensin II .
    Forasartan
  • HY-RI01064
    hsa-miR-4458 inhibitor

    		MicroRNA Cancer
    hsa-miR-4458 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    hsa-miR-4458 inhibitor
    hsa-miR-4458 inhibitor
  • HY-B0878R
    Halobetasol propionate (Standard)
    1 Publications Verification

    BMY-30056 (Standard); CGP-14458 (Standard); Ulobetasol propionate (Standard)

    		 Reference Standards Glucocorticoid Receptor Inflammation/Immunology
    Halobetasol propionate (Standard) (BMY-30056 (Standard)) is the analytical standard of Halobetasol propionate (HY-B0878). This product is intended for research and analytical applications. Halobetasol propionate (BMY-30056) is a synthetic glucocorticoid corticosteroid. Halobetasol propionate exhibits anti-inflammatory, antipruritic, and vasoconstrictive properties. Halobetasol propionate can be used for the study of psoriasis .
    Halobetasol propionate (Standard)
  • HY-19289
    MC-02479

    RWJ 54428

    		 Bacterial Infection
    MC-02479 is a novel cephalosporin. RWJ-54428 has good activity against most of the organisms tested, including methicillin-resistant staphylococci, E. faecalis, and penicillin-resistant pneumococci, and has moderate activity against E. faecium .
    MC-02479
  • HY-124987
    MRS4458

    		Endogenous Metabolite Inflammation/Immunology
    MRS4458 is a P2Y14 receptor antagonist with anti-inflammatory activity. MRS4458 mediates inflammatory activity by activating the motility of neutrophils. The design of MRS4458 is based on the interaction with the P2Y14 receptor and optimized by molecular dynamic simulation. MRS4458 performs well in terms of shape and complementarity with the receptor. The prediction that the 5-phenyl group of MRS4458 is substituted with thiophene is generally consistent with empirical results. The biological activity of MRS4458 was verified by fluorescence assay, showing its potent antagonistic effect .
    MRS4458
  • HY-B0878S
    Halobetasol propionate-d5

    BMY-30056-d5; CGP-14458-d5; Ulobetasol propionate-d5

    		 Isotope-Labeled Compounds Glucocorticoid Receptor Inflammation/Immunology
    Halobetasol propionate-d5 (BMY-30056-d5) is deuterium labeled Halobetasol propionate (HY-B0878). Halobetasol propionate (BMY-30056) is a synthetic glucocorticoid corticosteroid. Halobetasol propionate exhibits anti-inflammatory, antipruritic, and vasoconstrictive properties. Halobetasol propionate can be used for the study of psoriasis .
    Halobetasol propionate-d5
  • HY-R01064A
    hsa-miR-4458 agomir

    		MicroRNA Cancer
    hsa-miR-4458 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-4458 agomir
    hsa-miR-4458 agomir
  • HY-RI01064A
    hsa-miR-4458 antagomir

    		MicroRNA Cancer
    hsa-miR-4458 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-4458 antagomir
    hsa-miR-4458 antagomir

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