145216-43-9
Chemical Structure
Forasartan
Synonym(s): SC-52458
- CAS No.: 145216-43-9
- Formula:C23H28N8
- Molecular Weight:416.52
IUPAC Name: 2-(2-(2H-tetrazol-5-yl)phenyl)-5-((3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl)pyridine
InChIKey: YONOBYIBNBCDSJ-UHFFFAOYSA-N
SMILES: CCCCC1=NC(CCCC)=NN1CC2=CN=C(C3=CC=CC=C3C4=NNN=N4)C=C2
Biological Activity: Forasartan is an nonpeptide angiotensin AT1 receptor antagonist with an IC50 of 2.9 nM. Forasartan is also an anti-hypertension agent. Forasartan significantly inhibits preganglionic stimulation in a dose-dependent manner in vivo. Forasartan can inhibit the heart rate increase induced by angiotensin II[1][2][3].
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Forasartan | Forasartan is an nonpeptide angiotensin AT1 receptor antagonist with an IC50 of 2.9 nM. Forasartan is also an anti-hypertension agent. Forasartan significantly inhibits preganglionic stimulation in a dose-dependent manner in vivo. Forasartan can inhibit the heart rate increase induced by angiotensin II. | |||||||||||||||||||||
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- [1]. Tokunaga, R., et al., (2001). Possible involvement of calcium-calmodulin pathways in the positive chronotropic response to angiotensin II on the canine cardiac sympathetic ganglia. Japanese journal of pharmacology, 86(4), 381-389. [Content Brief]
- [2]. Gul, F., Parvaiz, N., & Azam, S. S. (2023). Deciphering the relational dynamics of AF-2 domain of PAN PPAR through drug repurposing and comparative simulations. PloS one, 18(3), e0283743. [Content Brief]
Keywords
