CCNL1 - cyclin L1 Gene

Also Known as ANIA6A; BM-001; PRO1073; ania-6a

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57018

About CCNL1

Cytogenetic location: 3q25.31 Genomic coordinates (GRCh38): 3:157,143,121-157,160,147 (from NCBI)

This gene has 26 transcripts (splice variants), 221 orthologues and 6 paralogues. Broad expression in bone marrow (RPKM 197.4), appendix (RPKM 28.6) and 17 other tissues.

Summary

Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

CCNL1 Products (2)

mRNA Protein Name
NM_001308185.2 NP_001295114.1 cyclin-L1 isoform 2
NM_020307.4 NP_064703.1 cyclin-L1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23455924 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of RNA splicing IDA
IDA: Inferred from direct assay
12501247 GOA
Cellular Component GO Annotation Evidence References Source
part of cyclin-dependent protein kinase holoenzyme complex IPI
IPI: Inferred from physical interaction
18216018 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17494991 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCNL1 Protein Structure

Cyclin_N

Cyclin_N: Cyclin, N-terminal domain (77 - 196)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 526 a.a.
Protein Preferred Names Protein Names

cyclin-L1

  • cyclin L ania-6a

CCNL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CCNL1 Q9UK58 KRTAP12-2 Homo sapiens P59991
Y2H Array
32296183
Intra
CCNL1 Q9UK58 KRTAP12-2 Homo sapiens P59991
Y2H Prey Pooling
32296183
Intra
CCNL1 Q9UK58 SREK1IP1 Homo sapiens Q8N9Q2
Y2H Array
32296183
Intra
CCNL1 Q9UK58 TFIP11 Homo sapiens Q9UBB9
Y2H Array
25416956
Intra
CCNL1 Q9UK58 PRDM6 Homo sapiens Q9NQX0
Y2H Prey Pooling
32296183
Intra
CCNL1 Q9UK58 PRDM6 Homo sapiens Q9NQX0
Y2H Array
32296183
Intra
CCNL1 Q9UK58 CASP8 Homo sapiens Q6NVI2
Y2H Array
32296183
Intra
CCNL1 Q9UK58 CASP8 Homo sapiens Q6NVI2
Y2H Prey Pooling
32296183
Intra
CCNL1 Q9UK58 NKAPD1 Homo sapiens Q6ZUT1
Y2H Array
32296183
Intra
CCNL1 Q9UK58 NKAPD1 Homo sapiens Q6ZUT1
Y2H Prey Pooling
32296183
Intra
CCNL1 Q9UK58 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra
CCNL1 Q9UK58 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra
CCNL1 Q9UK58 DVL3 Homo sapiens Q92997
Y2H Prey Pooling
32296183
Intra
CCNL1 Q9UK58 DVL3 Homo sapiens Q92997
Y2H Array
32296183
Intra
CCNL1 Q9UK58 SORBS3 Homo sapiens O60504
Y2H Array
32296183
Intra
CCNL1 Q9UK58 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
Intra
CCNL1 Q9UK58 APPBP2 Homo sapiens Q92624
Y2H Array
25416956
Intra
CCNL1 Q9UK58 RSRP1 Homo sapiens Q9BUV0
Y2H Array
32296183
Intra
CCNL1 Q9UK58 RSRP1 Homo sapiens Q9BUV0
Y2H Prey Pooling
32296183
Intra
CCNL1 Q9UK58 SAP30BP Homo sapiens Q9UHR5
Anti Tag CoIP
33961781
Intra
CCNL1 Q9UK58 JMJD6 Homo sapiens Q6NYC1
Y2H
23455924
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Tarsal Tunnel Syndrome

  • Neuropathy Of The Posterior Tibial Nerve And Its Branches

  • Posterior Tibial Nerve Neuralgia

  • Compression Of Posterior Tibial Nerve In Tarsal Tunnel
Tibial Neuropathy

  • Posterior Tibial Neuropathy
Alzheimer Disease 6

  • Ad6

  • Alzheimer Disease 6, Late-Onset

  • Alzheimer'S Disease 6

  • Alzheimer Disease 6, Late Onset
Plantar Fasciitis

  • Fasciitis, Plantar
Squamous Cell Carcinoma, Head And Neck

  • Squamous Cell Carcinoma Of The Head And Neck

  • HNSCC

  • Head And Neck Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Lip

  • Squamous Cell Carcinoma, Head And Neck, Somatic

  • Carcinoma Of The Head And Neck

  • Squamous Cell Carcinomas Of Head And Neck

  • Scchn

  • Squamous Cell Carcinoma Of The Hypopharynx

  • Squamous Cell Carcinoma Of The Oropharynx

  • Squamous Cell Carcinoma Of Salivary Glands

  • Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses

  • Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses

  • Squamous Cell Carcinoma Of The Oral Cavity

  • Squamous Cell Carcinoma Of The Lip

  • Carcinoma, Squamous Cell Of Head And Neck

  • Lip Squamous Cell Carcinoma

  • Carcinoma, Squamous Cell, Head And Neck

  • Salivary Gland Squamous Cell Carcinoma

  • Cancer Of Head And Neck

  • Squamous Cell Carcinoma Of Oropharynx Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02136 CCNL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08234 MCM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CCNL1 VGNC VGNC:26975
Mus musculus CCNL1 MGD MGI:1922664
Macaca mulatta CCNL1 VGNC VGNC:70830
Felis catus CCNL1 VGNC VGNC:60566
Rattus norvegicus CCNL1 RGD RGD:620864
Others CCNL1 NCBI