APPBP2 - amyloid beta precursor protein binding protein 2 Gene

Homo sapiens

Also known as PAT1; APP-BP2; HS.84084

Gene ID: 10513 | Gene type: protein coding

About APPBP2

Cytogenetic location: 17q23.2 Genomic coordinates (GRCh38): 17:60,443,158-60,526,242 (from NCBI)

This gene has 6 transcripts (splice variants), 192 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 16.4), brain (RPKM 11.4) and 25 other tissues.

Summary

The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. The encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in breast Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

APPBP2 Products(2)

mRNA	Protein	Name
NM_001282476.2	NP_001269405.1	amyloid protein-binding protein 2 isoform 2
NM_006380.5	NP_006371.2	amyloid protein-binding protein 2 isoform 1

APPBP2 Protein Structure

TPR_12

TPR_10

0
100
200
300
400
500
585 a.a.

Protein Preferred Names

Protein Names

amyloid protein-binding protein 2

amyloid beta precursor protein (cytoplasmic tail) binding protein 2

Related Diseases

Diseases

Alias

Ovarian Clear Cell Adenocarcinoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00866	APPBP2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	APPBP2	VGNC	VGNC:69991
Canis familiaris	APPBP2	VGNC	VGNC:38011
Bos taurus	APPBP2	VGNC	VGNC:26039
Felis catus	APPBP2	VGNC	VGNC:67891
Rattus norvegicus	APPBP2	RGD	RGD:1306488
Mus musculus	APPBP2	MGD	MGI:1914134

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