SLC22A6 - solute carrier family 22 member 6 Gene

Homo sapiens

Also known as OAT1; PAHT; HOAT1; ROAT1

Gene ID: 9356 | Gene type: protein coding

About SLC22A6

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:62,976,597-62,984,967 (from NCBI)

This gene has 6 transcripts (splice variants), 489 orthologues and 22 paralogues. Restricted expression toward kidney (RPKM 150.9).

Summary

The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

SLC22A6 Products(4)

mRNA	Protein	Name
NM_004790.5	NP_004781.2	solute carrier family 22 member 6 isoform a
NM_153276.3	NP_695008.1	solute carrier family 22 member 6 isoform b
NM_153277.3	NP_695009.1	solute carrier family 22 member 6 isoform c
NM_153278.3	NP_695010.1	solute carrier family 22 member 6 isoform d

SLC22A6 Protein Structure

Sugar_tr

0
100
200
300
400
500
563 a.a.

Protein Preferred Names

Protein Names

solute carrier family 22 member 6

PAH transporter

Related Diseases

Diseases

Alias

Hyperuricemia

Blood Urate Raized

Uricacidemia

Fanconi-Like Syndrome

Fanconi Like Syndrome

Gout

Gouty Arthritis	Articular Gout
Gouty Arthropathy	Arthritis, Gouty
Arthritis Gouty	Idiopathic Gout
Idiopathic Gout, Unspecified Site	Gouty Bursitis
Uratic Arthritis	Gout Nos
Gouty	Gouty Diathesis

Acute Kidney Failure

Acute Renal Failure	Acute Kidney Injury
Renal Failure Acute	Kidney Failure, Acute
Pre-Renal Acute Kidney Injury	Nontraumatic Acute Kidney Injury
Aki - [Acute Kidney Injury]	Arf - [Acute Kidney Failure]
Acute Kidney Disease	Acute Kidney Impairment
Acute Ischaemic Renal Failure	Acute Hypoxic Kidney Failure
Acute Kidney Shutdown	Acute Renal Oedema
Acute Renal Impairment	Acute Kidney Collapse
Acute Necrotising Kidney	Acute Renal Suppression

Fanconi Syndrome

Infantile Nephropathic Cystinosis	Adult Fanconi Syndrome
Congenital Fanconi Syndrome	De Toni-Fanconi Syndrome
Fanconi-De Toni Syndrome	Lignac-Fanconi Syndrome
Fanconi Renotubular Syndrome	Primary Fanconi Renotubular Syndrome
De Toni-Debre-Fanconi Syndrome	Adult Fanconi Anemia
Detoni Fanconi Syndrome	Fanconi-De-Toni Syndrome
Primary Fanconi Syndrome	Detoni-Debre-Fanconi Syndrome
Primary Fanconi Renal Syndrome	Fanconi Anemia
Cystinosis, Infantile Nephropathic	Fanconi-Bickel Syndrome
Renal Fanconi Syndrome	Lowe-Bickel Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13078	SLC22A6 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC22A6	RGD	RGD:69338
Felis catus	SLC22A6	VGNC	VGNC:104330
Macaca mulatta	SLC22A6	VGNC	VGNC:77421
Canis familiaris	SLC22A6	VGNC	VGNC:46280
Mus musculus	SLC22A6	MGD	MGI:892001
Others	SLC22A6	NCBI

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