GCSAM - germinal center associated signaling and motility Gene

Also Known as HGAL; GCAT2; GCET2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 257144

About GCSAM

Cytogenetic location: 3q13.2 Genomic coordinates (GRCh38): 3:112,120,839-112,133,248 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 77 orthologues and 1 paralogue. Biased expression in lymph node (RPKM 14.9), skin (RPKM 5.8) and 13 other tissues.

Summary

This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GCSAM Products (3)

mRNA	Protein	Name
NM_001190259.2	NP_001177188.1	germinal center-associated signaling and motility protein isoform 3
NM_001190260.2	NP_001177189.1	germinal center-associated signaling and motility protein isoform 4
NM_152785.5	NP_689998.1	germinal center-associated signaling and motility protein isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables actin binding	IPI IPI: Inferred from physical interaction	17823310	GOA
enables myosin II binding	IPI IPI: Inferred from physical interaction	17823310	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20844236	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	23299888	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of lymphocyte migration	IMP IMP: Inferred from mutant phenotype	17823310	GOA
involved in regulation of B cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23299888	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
germinal center-associated signaling and motility protein	germinal center B-cell-expressed transcript 2 protein

GCSAM Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GCSAM	Q8N6F7	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	GCSAM	Q8N6F7	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	GCSAM	Q8N6F7	AP1M1	Homo sapiens	Q9BXS5	Validated Y2H	32296183
Intra	GCSAM	Q8N6F7	CNOT2	Homo sapiens	Q9NZN8	Validated Y2H	32296183
Intra	GCSAM	Q8N6F7	APPBP2	Homo sapiens	Q92624	Y2H Array	32296183
Intra	GCSAM	Q8N6F7	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	25416956
Intra	GCSAM	Q8N6F7	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	32296183
Intra	GCSAM	Q8N6F7	APPBP2	Homo sapiens	Q92624	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

GCSAM Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81387	GCET2 Antibody (YA1132)	IHC-P	Human
HY-P81387A	GCET2 Antibody (YA1132)(PBS only)	IHC-P	Human
HY-P86267	GCET2 Antibody (YA5959)	IHC-P, ICC/IF, FC	Human

Related Diseases

Diseases	Alias
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Diffuse Large B-Cell Lymphoma	Dlbcl Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Large B-Cell Diffuse Lymphoma Lymphoma, Large B-Cell, Diffuse Dlbcl - [Diffuse Large B-Cell Lymphoma] Diffuse Large Beta Cell Lymphoma
Renal Pelvis Transitional Cell Carcinoma	Urothelial Cell Carcinoma Of Renal Pelvis Renal Pelvis Urothelial Carcinoma Transitional Cell Carcinoma Of Renal Pelvis
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Alzheimer Disease 17	AD17 Alzheimer'S Disease 17 Alzheimer Disease 17, Late-Onset Alzheimer Disease 17, Late Onset
Retroperitoneal Lymphoma
Nodal Marginal Zone Lymphoma	Mucosa-Associated Lymphoid Tissue Lymphoma Monocytoid B-Cell Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05343	GCSAM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GCSAM	VGNC	VGNC:29293
Mus musculus	GCSAM	MGD	MGI:102969
Felis catus	GCSAM	VGNC	VGNC:102727
Rattus norvegicus	GCSAM	RGD	RGD:1591321
Macaca mulatta	GCSAM	VGNC	VGNC:72752
Canis familiaris	GCSAM	VGNC	VGNC:41152
Others	GCSAM	NCBI