GCET2 Antibody (YA5959)
(Synonyms: GCSAM; GAL; GCET2; Germinal center-associated signaling and motility protein ; Germinal center B-cell-expressed transcript 2 protein; Germinal center-associated lymphoma protein; hGAL; )GCET2 Antibody (YA5959) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GCET2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P, ICC/IF, FC
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Reactivity :
Human
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Formulation:
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC
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FC 1
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|---|---|---|---|
| Dilution Ratio | 1:100-300 | ICC/IF: 1:100-300 | 100-300 |
Product Details
GCET2 Antibody (YA5959) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GCET2.
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Host Rabbit
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 20 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
GCET2 is involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation
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Subcellular Localization
Cytoplasm; Cell membrane
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Expression
Tissue_specificity:It is expressed (protein level) in diffuse large B-cell lymphoma (DLBCL) and various germinal center (GC) -like lymphoma cell lines. It is highly expressed in normal GC lymphocytes and GC-derived malignancies. It is also expressed in the thymus and spleen.
Induction:Up-regulated by IL4/interleukin-4 -
Isoforms & Post-Translational Modification
Q8N6F7 has 3 isomers: Q8N6F7-1: 21005 Da (predicted); Q8N6F7-2: 21240 Da (predicted); Q8N6F7-3: 19206 Da (predicted).
Phosphorylation on tyrosine residues can be induced by IL6. Phosphorylation is mediated by LYN;Targeted by the ubiquitin E3 ligase subunit FBXO10 to mediate its ubiquitination and degradation -
Subunit
Interacts with ACTB and MYH2; the interaction with MYH2 is increased by IL6-induced phosphorylation. Interacts (via C-terminus) with ARHGEF11 (via DH domain).
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SwissProt ID
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Synonyms
GCSAM; GAL; GCET2; Germinal center-associated signaling and motility protein ; Germinal center B-cell-expressed transcript 2 protein; Germinal center-associated lymphoma protein; hGAL;
Documentation
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