2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. GCET2 Antibody (YA1132)

GCET2 Antibody (YA1132) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GCET2.

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Tamaño Precio Stock Cantidad
20 μL Obtener un presupuesto 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL Obtener un presupuesto 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL Obtener un presupuesto 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   Obtener un presupuesto  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

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  • Background

  • Descripciòn

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Descripciòn

GCET2 Antibody (YA1132) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GCET2.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Peso molecular
Predicted band size: 21 kDa;
Observed band size: 21 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

Recombinant protein of human GCET2
Application &
Dilution Ratio
Application Dilution Ratio
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:100-1:200
Sensitivity Endogenous Pureza Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.206.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Envío

Shipping with blue ice.
Background
Function：Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation
Subcellular Localization：Cytoplasm; Cell membrane
Expression：
Tissue_specificity:It is expressed (protein level) in diffuse large B-cell lymphoma (DLBCL) and various germinal center (GC) -like lymphoma cell lines. It is highly expressed in normal GC lymphocytes and GC-derived malignancies. It is also expressed in the thymus and spleen.

Induction:Up-regulated by IL4/interleukin-4
Isoforms & Post-Translational Modification：Q8N6F7 has 3 isomers: Q8N6F7-1: 21005 Da (predicted); Q8N6F7-2: 21240 Da (predicted); Q8N6F7-3: 19206 Da (predicted).
Phosphorylation on tyrosine residues can be induced by IL6. Phosphorylation is mediated by LYN;Targeted by the ubiquitin E3 ligase subunit FBXO10 to mediate its ubiquitination and degradation
Subunit：Interacts with ACTB and MYH2; the interaction with MYH2 is increased by IL6-induced phosphorylation. Interacts (via C-terminus) with ARHGEF11 (via DH domain).
Database

Entrez Gene: 257144 Human

SwissProt: Q8N6F7 Human

OMIM: 607792 Human

Research Field

Immunology
Synonyms
GCAT2; Gcet; Gcsam; hGAL; M17; M17 L
Documentación
User Guide for Antibodies (1077 KB)
Referencias

GCET2 Antibody (YA1132) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

Nombre del producto:
GCET2 Antibody (YA1132)
Cat. No.:
HY-P81387
Cantidad:
MCE Japan Authorized Agent:

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