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TBL3 - transducin beta like 3 Gene

Also Known as SAZD; UTP13

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10607

About TBL3

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,972,053-1,982,929 (from NCBI)

This gene has 7 transcripts (splice variants), 200 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 14.6), skin (RPKM 6.9) and 25 other tissues.

Summary

The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This gene has multiple polyadenylation sites. It might have multiple alternatively spliced transcript variants but the variants have not been fully described yet. [provided by RefSeq, Jul 2008]

TBL3 Products (1)

mRNA	Protein	Name
NM_006453.3	NP_006444.2	transducin beta-like protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TBL3 Protein Structure

WD40

Utp13

0
200
400
600
808 a.a.

Protein Preferred Names	Protein Names
transducin beta-like protein 3	WD repeat-containing protein SAZD

TBL3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TBL3	Q12788	APPBP2	Homo sapiens	Q92624	Validated Y2H	25416956
Intra	TBL3	Q12788	APPBP2	Homo sapiens	Q92624	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Theileriasis	Theileriosis Infection By Theileria

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-158060	MC2646		/	Unkown
HY-RS14265	TBL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TBL3	MGD	MGI:2384863
Felis catus	TBL3	VGNC	VGNC:65999
Bos taurus	TBL3	VGNC	VGNC:35659
Macaca mulatta	TBL3	VGNC	VGNC:78109
Canis familiaris	TBL3	VGNC	VGNC:47163
Rattus norvegicus	TBL3	RGD	RGD:1305142
Others	TBL3	NCBI