SLC25A23 - solute carrier family 25 member 23 Gene

Also Known as APC2; MCSC2; SCAMC3; SCaMC-3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79085

About SLC25A23

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:6,436,081-6,459,792 (from NCBI)

This gene has 13 transcripts (splice variants), 198 orthologues and 49 paralogues. Ubiquitous expression in brain (RPKM 40.2), thyroid (RPKM 28.7) and 23 other tissues.

Summary

Predicted to enable ATP transmembrane transporter activity. Involved in calcium import into the mitochondrion; positive regulation of mitochondrial calcium ion concentration; and regulation of cellular hyperosmotic salinity response. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

SLC25A23 Products (1)

mRNA	Protein	Name
NM_024103.3	NP_077008.2	calcium-binding mitochondrial carrier protein SCaMC-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ADP:phosphate antiporter activity	IDA IDA: Inferred from direct assay	15123600	GOA
enables ATP:phosphate antiporter activity	IDA IDA: Inferred from direct assay	15123600	GOA
enables adenine nucleotide transmembrane transporter activity	IDA IDA: Inferred from direct assay	15123600	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24430870	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adenine nucleotide transport	IDA IDA: Inferred from direct assay	15123600	GOA
involved in calcium import into the mitochondrion	IMP IMP: Inferred from mutant phenotype	24430870	GOA
involved in mitochondrial ATP transmembrane transport	IDA IDA: Inferred from direct assay	15123600	GOA
involved in mitochondrial calcium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	24430870	GOA
involved in positive regulation of mitochondrial calcium ion concentration	IMP IMP: Inferred from mutant phenotype	26975899	GOA
involved in regulation of cellular hyperosmotic salinity response	IMP IMP: Inferred from mutant phenotype	26975899	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	15054102	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC25A23 Protein Structure

EF-hand_6

EF-hand_7

Mito_carr

0
100
200
300
400
468 a.a.

Protein Preferred Names	Protein Names
calcium-binding mitochondrial carrier protein SCaMC-3	mitochondrial ATP-Mg/Pi carrier protein 2

SLC25A23 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC25A23	Q9BV35	APPBP2	Homo sapiens	Q92624	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Ichthyosis, Congenital, Autosomal Recessive 11	Autosomal Recessive Congenital Ichthyosis 11 Ichthyosis With Hypotrichosis, Autosomal Recessive Arih Ichthyosis And Follicular Atrophoderma With Hypotrichosis And Hypohidrosis Autosomal Recessive Ichthyosis With Hypotrichosis ARCI11 Ifah Hypotrichosis-Congenital Ichthyosis Syndrome Ichthyosis-Follicular Atrophoderma-Hypotrichosis Syndrome Ichthyosis-Follicular Atrophoderma-Hypotrichosis-Hypohidrosis Syndrome Ichthyosis-Hypotrichosis Syndrome Ifah Syndrome Ihs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13104	SLC25A23 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC25A23	RGD	RGD:1588586
Macaca mulatta	SLC25A23	VGNC	VGNC:107116
Mus musculus	SLC25A23	MGD	MGI:1914222
Bos taurus	SLC25A23	VGNC	VGNC:55309
Felis catus	SLC25A23	VGNC	VGNC:80716
Canis familiaris	SLC25A23	VGNC	VGNC:106610
Others	SLC25A23	NCBI