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MUL1 - mitochondrial E3 ubiquitin protein ligase 1 Gene

Also Known as GIDE; MAPL; MULAN; RNF218; C1orf166

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79594

About MUL1

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:20,499,448-20,508,151 (from NCBI)

This gene has 1 transcript (splice variant) and 206 orthologues. Ubiquitous expression in kidney (RPKM 8.0), heart (RPKM 7.9) and 25 other tissues.

Summary

Enables several functions, including p53 binding activity; ubiquitin protein Ligase binding activity; and ubiquitin-like protein transferase activity. Involved in several processes, including negative regulation of defense response; positive regulation of cellular protein metabolic process; and regulation of mitochondrion organization. Located in several cellular components, including mitochondrion; neuronal cell body; and peroxisome. Is integral component of mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]

MUL1 Products (1)

mRNA	Protein	Name
NM_024544.3	NP_078820.2	mitochondrial ubiquitin ligase activator of NFKB 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SUMO transferase activity	IDA IDA: Inferred from direct assay	19407830	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	18591963	GOA
enables p53 binding	IPI IPI: Inferred from physical interaction	21597459	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	18213395	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	19407830	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	18591963	GOA
involved in cellular response to exogenous dsRNA	IDA IDA: Inferred from direct assay	23399697	GOA
involved in mitochondrial fission	IMP IMP: Inferred from mutant phenotype	18207745	GOA
involved in mitochondrion localization	IMP IMP: Inferred from mutant phenotype	18213395	GOA
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	18591963	GOA
involved in negative regulation of chemokine (C-C motif) ligand 5 production	IMP IMP: Inferred from mutant phenotype	23399697	GOA
involved in negative regulation of defense response to virus by host	IMP IMP: Inferred from mutant phenotype	23399697	GOA
involved in negative regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	23399697	GOA
involved in negative regulation of mitochondrial fusion	IDA IDA: Inferred from direct assay	19407830	GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	22410793	GOA
involved in negative regulation of type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	23399697	GOA
involved in positive regulation of mitochondrial fission	IDA IDA: Inferred from direct assay	19407830	GOA
involved in positive regulation of protein sumoylation	IDA IDA: Inferred from direct assay	19407830	GOA
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	24898855	GOA
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	21597459	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	19407830	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	18213395	GOA
involved in regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IDA IDA: Inferred from direct assay	18591963	GOA
involved in regulation of mitochondrion organization	IMP IMP: Inferred from mutant phenotype	24898855	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IMP IMP: Inferred from mutant phenotype	24898855	GOA
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	18207745	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	21597459	GOA
located in mitochondrion	IMP IMP: Inferred from mutant phenotype	24898855	GOA
located in neuronal cell body	IMP IMP: Inferred from mutant phenotype	24898855	GOA
located in peroxisome	IDA IDA: Inferred from direct assay	18207745	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MUL1 Protein Structure

GIDE

zf-C3HC4_3

0
100
200
300
352 a.a.

Protein Preferred Names	Protein Names
mitochondrial ubiquitin ligase activator of NFKB 1	E3 SUMO-protein ligase MUL1

MUL1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MUL1	Q969V5	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	MUL1	Q969V5	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	MUL1	Q969V5	REEP2	Homo sapiens	Q9BRK0	Y2H Array	32296183
Intra	MUL1	Q969V5	REEP2	Homo sapiens	Q9BRK0	Y2H Prey Pooling	32296183
Intra	MUL1	Q969V5	REEP2	Homo sapiens	Q9BRK0	Validated Y2H	32296183
Intra	MUL1	Q969V5	TRIM9	Homo sapiens	Q9C026	Y2H Prey Pooling	25416956
Intra	MUL1	Q969V5	APPBP2	Homo sapiens	Q92624	Y2H Array	32296183
Intra	MUL1	Q969V5	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Parkinson Disease 2, Autosomal Recessive Juvenile	Young-Onset Parkinson Disease PARK2 Pdj Autosomal Recessive Juvenile Parkinson Disease 2 Epdf Parkinson Disease, Juvenile, Type 2 Parkinson'S Disease 2 Autosomal Recessive Juvenile Parkinson Disease Early-Onset Parkinson Disease Parkinson Disease 2 Parkinson Disease, Juvenile, Autosomal Recessive Parkinsonism, Early-Onset, With Diurnal Fluctuation Autosomal Recessive Juvenile Parkinson'S Disease 2 Jp Juvenile Parkinsonism Parkinson Disease Autosomal Recessive, Early Onset Parkinsonism, Early Onset, With Diurnal Fluctuation Yopd Autosomal Recessive Early-Onset Parkinson Disease Type 2 Chromosome 6-Linked Autosomal Recessive Parkinsonism Early-Onset Parkinsonism With Diurnal Fluctuation Parkinsonism Young Adult Onset Parkinson Disease, Type 2 Parkinsonism, Juvenile

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08850	MUL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21381	Mul1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27900	Mul1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MUL1	VGNC	VGNC:63665
Bos taurus	MUL1	VGNC	VGNC:31760
Rattus norvegicus	MUL1	RGD	RGD:1309944
Mus musculus	MUL1	MGD	MGI:1915600
Macaca mulatta	MUL1	VGNC	VGNC:106413
Canis familiaris	MUL1	VGNC	VGNC:43501
Others	MUL1	NCBI