TRIM9 - tripartite motif containing 9 Gene

Also Known as RNF91; SPRING

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 114088

About TRIM9

Cytogenetic location: 14q22.1 Genomic coordinates (GRCh38): 14:50,975,266-51,095,105 (from NCBI)

This gene has 7 transcripts (splice variants), 204 orthologues and 80 paralogues. Biased expression in brain (RPKM 15.3), gall bladder (RPKM 1.4) and 1 other tissue.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

TRIM9 Products (23)

mRNA Protein Name
NM_001387360.1 NP_001374289.1 E3 ubiquitin-protein ligase TRIM9 isoform 3
NM_001387361.1 NP_001374290.1 E3 ubiquitin-protein ligase TRIM9 isoform 4
NM_001387362.1 NP_001374291.1 E3 ubiquitin-protein ligase TRIM9 isoform 5
NM_001387363.1 NP_001374292.1 E3 ubiquitin-protein ligase TRIM9 isoform 6
NM_001387364.1 NP_001374293.1 E3 ubiquitin-protein ligase TRIM9 isoform 7
NM_001387365.1 NP_001374294.1 E3 ubiquitin-protein ligase TRIM9 isoform 8
NM_001387366.1 NP_001374295.1 E3 ubiquitin-protein ligase TRIM9 isoform 9
NM_001387367.1 NP_001374296.1 E3 ubiquitin-protein ligase TRIM9 isoform 10
NM_001387368.1 NP_001374297.1 E3 ubiquitin-protein ligase TRIM9 isoform 11
NM_001387369.1 NP_001374298.1 E3 ubiquitin-protein ligase TRIM9 isoform 12
NM_001387370.1 NP_001374299.1 E3 ubiquitin-protein ligase TRIM9 isoform 13
NM_001387371.1 NP_001374300.1 E3 ubiquitin-protein ligase TRIM9 isoform 14
NM_001387372.1 NP_001374301.1 E3 ubiquitin-protein ligase TRIM9 isoform 15
NM_001387373.1 NP_001374302.1 E3 ubiquitin-protein ligase TRIM9 isoform 16
NM_001387374.1 NP_001374303.1 E3 ubiquitin-protein ligase TRIM9 isoform 17
NM_001387375.1 NP_001374304.1 E3 ubiquitin-protein ligase TRIM9 isoform 18
NM_001387376.1 NP_001374305.1 E3 ubiquitin-protein ligase TRIM9 isoform 19
NM_001387377.1 NP_001374306.1 E3 ubiquitin-protein ligase TRIM9 isoform 20
NM_001387378.1 NP_001374307.1 E3 ubiquitin-protein ligase TRIM9 isoform 21
NM_001387379.1 NP_001374308.1 E3 ubiquitin-protein ligase TRIM9 isoform 22
NM_001387380.1 NP_001374309.1 E3 ubiquitin-protein ligase TRIM9 isoform 23
NM_015163.6 NP_055978.4 E3 ubiquitin-protein ligase TRIM9 isoform 1
NM_052978.5 NP_443210.1 E3 ubiquitin-protein ligase TRIM9 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
22084112 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
11331580 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
20085810 GOA
Biological Process GO Annotation Evidence References Source
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
20085810 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11331580 GOA
located in dendrite IDA
IDA: Inferred from direct assay
20085810 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM9 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (10 - 39)

zf-B_box

zf-B_box: B-box zinc finger (226 - 265)

fn3

fn3: Fibronectin type III domain (454 - 525)

SPRY

SPRY: SPRY domain (577 - 693)

  • 0
  • 200
  • 400
  • 600
  • 710 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase TRIM9

  • RING finger protein 91

TRIM9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TRIM9 Q9C026 NFKBID Homo sapiens Q8NI38
Y2H Prey Pooling
25416956
Intra
TRIM9 Q9C026 NFKBID Homo sapiens Q8NI38
Validated Y2H
25416956
Intra
TRIM9 Q9C026 NFKBID Homo sapiens Q8NI38
Y2H Array
25416956
Intra
TRIM9 Q9C026 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
TRIM9 Q9C026 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
TRIM9 Q9C026 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
TRIM9 Q9C026 FAM124B Homo sapiens Q9H5Z6-2
Validated Y2H
32296183
Intra
TRIM9 Q9C026 AP3M1 Homo sapiens Q9Y2T2
Y2H Prey Pooling
25416956
Intra
TRIM9 Q9C026 AP3M1 Homo sapiens Q9Y2T2
Validated Y2H
25416956
Intra
TRIM9 Q9C026 AP3M1 Homo sapiens Q9Y2T2
Y2H Array
25416956
Intra
TRIM9 Q9C026 GFM2 Homo sapiens Q969S9
Validated Y2H
25416956
Intra
TRIM9 Q9C026 GFM2 Homo sapiens Q969S9
Y2H Array
25416956
Intra
TRIM9 Q9C026 BTRC Homo sapiens Q9Y297
Y2H Prey Pooling
25416956
Intra
TRIM9 Q9C026 BTRC Homo sapiens Q9Y297
Validated Y2H
32296183
Intra
TRIM9 Q9C026 EVL Homo sapiens Q9UI08
Y2H Prey Pooling
25416956
Intra
TRIM9 Q9C026 EVL Homo sapiens Q9UI08
Y2H Array
25416956
Intra
TRIM9 Q9C026 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra
TRIM9 Q9C026 TSSK3 Homo sapiens Q96PN8
Y2H Prey Pooling
25416956
Intra
TRIM9 Q9C026 CWF19L2 Homo sapiens Q2TBE0
Y2H Array
25416956
Intra
TRIM9 Q9C026 CWF19L2 Homo sapiens Q2TBE0
Y2H Prey Pooling
25416956
Intra
TRIM9 Q9C026 EVL Homo sapiens Q9UI08-2
Validated Y2H
32296183
Intra
TRIM9 Q9C026 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Intra
TRIM9 Q9C026 SPG21 Homo sapiens Q9NZD8
Y2H Array
25416956
Intra
TRIM9 Q9C026 SPG21 Homo sapiens Q9NZD8
Validated Y2H
25416956
Intra
TRIM9 Q9C026 MUL1 Homo sapiens Q969V5
Validated Y2H
25416956
Intra
TRIM9 Q9C026 MUL1 Homo sapiens Q969V5
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Severe Congenital Neutropenia 4

  • Autosomal Recessive Severe Congenital Neutropenia Due To G6pc3 Deficiency

  • Scn4

  • Severe Congenital Neutropenia-Pulmonary Hypertension-Superficial Venous Angiectasis Syndrome

  • Dursun Syndrome

  • Severe Congenital Neutropenia Type 4
Dementia

  • Dementias

  • Presenile Dementia

  • Alzheimer Type Dementia

  • Alzheimer Sclerosis

  • Alzheimer Disease Dementia

  • Alzheimer Dementia

  • Primary Degenerative Alzheimer Type Dementia

  • End Stage Alzheimer'S Dementia

  • Alzheimer'S Type Atypical Dementia

  • Alzheimer Type Presenile Dementia

  • Early Onset Alzheimer Dementia

  • Dementia In Alzheimer Disease Type 2

  • Dementia In Alzheimer Disease With Early Onset

  • Early Onset Alzheimer Type Dementia, Uncomplicated

  • Primary Degenerative Alzheimer Type Dementia, Early Onset

  • Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated

  • Alzheimer Disease Dementia With Early Onset

  • Presenile Sclerosis

  • Presenile Brain Sclerosis

  • Presenile Alzheimer Brain Sclerosis

  • Late Onset Alzheimer Dementia

  • Dementia In Alzheimer Disease Type 1

  • Dementia In Alzheimer Disease With Late Onset

  • Primary Degenerative Alzheimer Type Dementia, Late Onset

  • Sdat - [Senile Dementia, Alzheimer Type]

  • Alzheimer Disease Dementia With Late Onset

  • Late Onset Alzheimer Brain Sclerosis

  • Senile Alzheimer Brain Disease

  • Senile Alzheimer Brain Sclerosis

  • Senile Primary Degenerative Alzheimer Type Dementia

  • Senile Dementia Of The Alzheimer Type

  • Arteriosclerotic Dementia

  • Strategic-Infarct Dementia

  • Post Stroke Dementia

  • Vascular Cognitive Impairment

  • Vascular Dementia

  • Dementia Of The Lewy Body Type

  • Dementia With Lewy Bodies

  • Sdlt - [Senile Dementia Of The Lewy Body Type]

  • Senile Dementia Of The Lewy Body Type

  • Alcohol-Related Dementia

  • Alcoholic Dementia Nos

  • Alcohol-Induced Dementia

  • Alcoholic Brain Syndrome

  • Chronic Alcoholic Brain Syndrome

  • Alcohol Dementia

  • Late Onset Alcoholic Psychosis

  • Residual And Late-Onset Alcohol-Induced Psychotic Disorder

  • Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder

  • Late-Onset Psychoactive Substance-Induced Psychotic Disorder

  • Inhalant Dementia

  • Volatile Solvents Dementia

  • Dementia In Paralysis Agitans

  • Pdd - [Parkinson Disease Dementia]

  • Dementia Syndrome Of Parkinson Disease

  • Dementia In Parkinson Disease

  • Parkinson Related Dementia

  • Dementia In Huntington Chorea

  • Hiv - [Human Immunodeficiency Virus] Dementia

  • Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex

  • Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex

  • Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex

  • Aids Related Dementia

  • Dementia Due To Niacin Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15073 TRIM9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21069 Trim9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27586 Trim9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TRIM9 VGNC VGNC:79027
Canis familiaris TRIM9 VGNC VGNC:47840
Rattus norvegicus TRIM9 RGD RGD:621540
Mus musculus TRIM9 MGD MGI:2137354
Felis catus TRIM9 VGNC VGNC:66556
Bos taurus TRIM9 VGNC VGNC:36353
Others TRIM9 NCBI