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NFKBID - NFKB inhibitor delta Gene

Also Known as IkBNS; TA-NFKBH; IkappaBNS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84807

About NFKBID

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,887,952-35,902,303 (from NCBI)

This gene has 11 transcripts (splice variants), 195 orthologues and 3 paralogues. Broad expression in bone marrow (RPKM 9.7), appendix (RPKM 2.8) and 19 other tissues.

Summary

Predicted to enable NF-kappaB binding activity. Predicted to be involved in T cell receptor signaling pathway; positive regulation of T-helper 17 cell differentiation; and regulation of gene expression. Predicted to act upstream of or within several processes, including negative regulation of NF-kappaB transcription factor activity; negative regulation of T cell differentiation in thymus; and positive regulation of thymocyte apoptotic process. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

NFKBID Products (5)

mRNA	Protein	Name
NM_001321831.2	NP_001308760.1	NF-kappa-B inhibitor delta isoform 2
NM_001365705.1	NP_001352634.1	NF-kappa-B inhibitor delta isoform 1
NM_001365706.2	NP_001352635.1	NF-kappa-B inhibitor delta isoform 4
NM_032721.3	NP_116110.2	NF-kappa-B inhibitor delta isoform 3
NM_139239.3	NP_640332.1	NF-kappa-B inhibitor delta isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NFKBID Protein Structure

Ank_2

0
100
200
313 a.a.

Protein Preferred Names	Protein Names
NF-kappa-B inhibitor delta	I-kappa-B-delta

NFKBID Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NFKBID	Q8NI38	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	NFKBID	Q8NI38	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	32296183
Intra	NFKBID	Q8NI38	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	TEKT5	Homo sapiens	Q96M29	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	SS18	Homo sapiens	Q4VAX2	Validated Y2H	25416956
Intra	NFKBID	Q8NI38	LGALS14	Homo sapiens	Q8TCE9	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	CTRC	Homo sapiens	Q99895	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	MYEF2	Homo sapiens	Q9P2K5-2	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	NFKBID	Q8NI38	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	PATZ1	Homo sapiens	Q9HBE1-4	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	NFKBID	Q8NI38	TRIML2	Homo sapiens	Q8N7C3	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	TRIML2	Homo sapiens	Q8N7C3	Y2H Array	32296183
Intra	NFKBID	Q8NI38	PRDM6	Homo sapiens	Q9NQX0	Y2H Array	32296183
Intra	NFKBID	Q8NI38	PRDM6	Homo sapiens	Q9NQX0	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	PRDM6	Homo sapiens	Q9NQX0	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	LMO3	Homo sapiens	Q8TAP4-4	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	NFKBID	Q8NI38	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	SAMD4A	Homo sapiens	Q9UPU9-3	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	RUNX1	Homo sapiens	Q01196-8	Y2H Array	32296183
Intra	NFKBID	Q8NI38	RUNX1	Homo sapiens	Q01196-8	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	FAAP20	Homo sapiens	Q6NZ36-4	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	FAAP20	Homo sapiens	Q6NZ36-4	Y2H Array	32296183
Intra	NFKBID	Q8NI38	SPMIP2	Homo sapiens	Q96LM5	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	LHX3	Homo sapiens	Q9UBR4-2	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	LHX3	Homo sapiens	Q9UBR4-2	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	LHX3	Homo sapiens	Q9UBR4-2	Y2H Array	32296183
Intra	NFKBID	Q8NI38	POMC	Homo sapiens	P01189	Y2H Array	32296183
Intra	NFKBID	Q8NI38	POMC	Homo sapiens	P01189	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	ESR2	Homo sapiens	Q92731-3	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	ZC2HC1B	Homo sapiens	Q5TFG8	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	ZC2HC1B	Homo sapiens	Q5TFG8	Y2H Array	32296183
Intra	NFKBID	Q8NI38	GRB10	Homo sapiens	Q13322-4	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	GRB10	Homo sapiens	Q13322-4	Y2H Array	32296183
Intra	NFKBID	Q8NI38	NDUFB7	Homo sapiens	P17568	Y2H Array	32296183
Intra	NFKBID	Q8NI38	NDUFB7	Homo sapiens	P17568	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	NICN1	Homo sapiens	Q9BSH3	Y2H Array	32296183
Intra	NFKBID	Q8NI38	NICN1	Homo sapiens	Q9BSH3	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	NICN1	Homo sapiens	Q9BSH3	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	NFKBID	Q8NI38	SAMD11	Homo sapiens	Q96NU1	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	NFKBID	Q8NI38	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	SNAPC3	Homo sapiens	Q92966	Y2H Array	32296183
Intra	NFKBID	Q8NI38	SNAPC3	Homo sapiens	Q92966	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	SNAPC3	Homo sapiens	Q92966	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	DTX3	Homo sapiens	Q8N9I9	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	DTX3	Homo sapiens	Q8N9I9	Y2H Array	32296183
Intra	NFKBID	Q8NI38	EFHC2	Homo sapiens	Q5JST6	Y2H Array	32296183
Intra	NFKBID	Q8NI38	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	MRPL53	Homo sapiens	Q96EL3	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	SMG9	Homo sapiens	Q9H0W8	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	KRT75	Homo sapiens	O95678	Y2H Array	32296183
Intra	NFKBID	Q8NI38	KRT75	Homo sapiens	O95678	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	KRT76	Homo sapiens	Q01546	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	KRT76	Homo sapiens	Q01546	Y2H Array	32296183
Intra	NFKBID	Q8NI38	ARHGEF2	Homo sapiens	Q92974	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	ARHGEF2	Homo sapiens	Q92974	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	ARHGEF2	Homo sapiens	Q92974	Y2H Array	32296183
Intra	NFKBID	Q8NI38	PRMT7	Homo sapiens	Q9NVM4	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	SMAD4	Homo sapiens	Q13485	Y2H Array	32296183
Intra	NFKBID	Q8NI38	SMAD4	Homo sapiens	Q13485	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	VIM	Homo sapiens	P08670	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	VIM	Homo sapiens	P08670	Y2H Array	32296183
Intra	NFKBID	Q8NI38	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	NFKBID	Q8NI38	GADD45GIP1	Homo sapiens	Q8TAE8	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	TSSK3	Homo sapiens	Q96PN8	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	HOXD3	Homo sapiens	P31249	Y2H Array	32296183
Intra	NFKBID	Q8NI38	HOXD3	Homo sapiens	P31249	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	UTP23	Homo sapiens	Q9BRU9	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	RBM4B	Homo sapiens	Q9BQ04	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	RBM41	Homo sapiens	Q96IZ5	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	HOXA1	Homo sapiens	P49639	Y2H Array	32296183
Intra	NFKBID	Q8NI38	SORBS3	Homo sapiens	O60504	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	SORBS3	Homo sapiens	O60504	Y2H Array	32296183
Intra	NFKBID	Q8NI38	TCF19	Homo sapiens	Q9Y242	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	KRT19	Homo sapiens	P08727	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	KRT19	Homo sapiens	P08727	Y2H Array	32296183
Intra	NFKBID	Q8NI38	GFAP	Homo sapiens	P14136	Y2H Array	32296183
Intra	NFKBID	Q8NI38	GFAP	Homo sapiens	P14136	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	BEX2	Homo sapiens	Q9BXY8	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	32296183
Intra	NFKBID	Q8NI38	PAX6	Homo sapiens	P26367	Y2H Array	32296183
Intra	NFKBID	Q8NI38	PAX6	Homo sapiens	P26367	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	TEKT4	Homo sapiens	Q8WW24	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	IHO1	Homo sapiens	Q8IYA8	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	IHO1	Homo sapiens	Q8IYA8	Y2H Array	32296183
Intra	NFKBID	Q8NI38	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	DDX25	Homo sapiens	Q9UHL0	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	C1orf94	Homo sapiens	Q6P1W5	Y2H Prey Pooling	25416956
Intra	NFKBID	Q8NI38	C1orf94	Homo sapiens	Q6P1W5	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	32296183
Intra	NFKBID	Q8NI38	C1orf94	Homo sapiens	Q6P1W5	Validated Y2H	25416956
Intra	NFKBID	Q8NI38	GIGYF1	Homo sapiens	O75420	Y2H Prey Pooling	32296183
Intra	NFKBID	Q8NI38	GIGYF1	Homo sapiens	O75420	Y2H Array	32296183
Intra	NFKBID	Q8NI38	RBM14	Homo sapiens	Q96PK6	Validated Y2H	32296183
Intra	NFKBID	Q8NI38	DMRT3	Homo sapiens	Q9NQL9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09262	NFKBID Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NFKBID	VGNC	VGNC:53742
Felis catus	NFKBID	VGNC	VGNC:63790
Macaca mulatta	NFKBID	VGNC	VGNC:75179
Bos taurus	NFKBID	VGNC	VGNC:32047
Mus musculus	NFKBID	MGD	MGI:3041243
Rattus norvegicus	NFKBID	RGD	RGD:1308055
Others	NFKBID	NCBI