DDX25 - DEAD-box helicase 25 Gene
Also Known as GRTH
Species: Homo sapiens
About DDX25
This gene has 10 transcripts (splice variants), 131 orthologues and 38 paralogues. Restricted expression toward testis (RPKM 40.9).
Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The encoded protein is a gonadotropin-regulated and developmentally expressed testicular RNA helicase. It may serve to maintain testicular functions related to steroidogenesis and spermatogenesis. [provided by RefSeq, Jul 2008]
DDX25 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001330438.2 | NP_001317367.1 | ATP-dependent RNA helicase DDX25 isoform 2 |
| NM_013264.5 | NP_037396.3 | ATP-dependent RNA helicase DDX25 isoform 1 |
DDX25 Protein Structure
DEAD: DEAD/DEAH box helicase (122 - 284)
Helicase_C: Helicase conserved C-terminal domain (359 - 439)
- 0
- 100
- 200
- 300
- 400
- 483 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
ATP-dependent RNA helicase DDX25 |
|
DDX25 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
DDX25 | Q9UHL0 | NFKBID | Homo sapiens | Q8NI38 | 32296183 | |
|
Intra
|
DDX25 | Q9UHL0 | NFKBID | Homo sapiens | Q8NI38 | 32296183 | |
|
Intra
|
DDX25 | Q9UHL0 | TFIP11 | Homo sapiens | Q9UBB9 | 32296183 | |
|
Intra
|
DDX25 | Q9UHL0 | TFIP11 | Homo sapiens | Q9UBB9 | 32296183 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Spermatogenic Failure |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | DDX25 | RGD | RGD:68381 |
| Macaca mulatta | DDX25 | VGNC | VGNC:71666 |
| Canis familiaris | DDX25 | VGNC | VGNC:39852 |
| Mus musculus | DDX25 | MGD | MGI:1353582 |
| Felis catus | DDX25 | VGNC | VGNC:61403 |
| Bos taurus | DDX25 | VGNC | VGNC:27961 |
| Others | DDX25 | NCBI |