DMRT3 - doublesex and mab-3 related transcription factor 3 Gene
Also Known as DMRTA3
Species: Homo sapiens
About DMRT3
This gene has 2 transcripts (splice variants), 190 orthologues, 8 paralogues and is associated with 1 phenotype. Biased expression in thyroid (RPKM 4.6), testis (RPKM 2.6) and 2 other tissues.
Summary
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in male sex differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including adult walking behavior; transmission of nerve impulse; and ventral spinal cord interneuron specification. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
DMRT3 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_021240.4 | NP_067063.1 | doublesex- and mab-3-related transcription factor 3 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
25416956 | GOA |
| enables sequence-specific double-stranded DNA binding |
IDA
IDA: Inferred from direct assay
|
28473536 | GOA |
DMRT3 Protein Structure
DM: DM DNA binding domain (25 - 71)
DMA: DMRTA motif (248 - 286)
- 0
- 100
- 200
- 300
- 400
- 472 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
doublesex- and mab-3-related transcription factor 3 |
|
DMRT3 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
DMRT3 | Q9NQL9 | KRT40 | Homo sapiens | Q6A162 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRT40 | Homo sapiens | Q6A162 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRT40 | Homo sapiens | Q6A162 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRT40 | Homo sapiens | Q6A162 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP10-8 | Homo sapiens | P60410 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP10-8 | Homo sapiens | P60410 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP10-8 | Homo sapiens | P60410 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP10-8 | Homo sapiens | P60410 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP10-8 | Homo sapiens | P60410 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP10-9 | Homo sapiens | P60411 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP10-9 | Homo sapiens | P60411 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP10-9 | Homo sapiens | P60411 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | MID2 | Homo sapiens | Q9UJV3-2 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | MID2 | Homo sapiens | Q9UJV3-2 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | MID2 | Homo sapiens | Q9UJV3-2 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | MID2 | Homo sapiens | Q9UJV3-2 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | GPSM1 | Homo sapiens | Q86YR5-3 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | GPSM1 | Homo sapiens | Q86YR5-3 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | NFKBID | Homo sapiens | Q8NI38 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | NFKBID | Homo sapiens | Q8NI38 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP9-3 | Homo sapiens | Q9BYQ3 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP9-3 | Homo sapiens | Q9BYQ3 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP9-2 | Homo sapiens | Q9BYQ4 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP9-2 | Homo sapiens | Q9BYQ4 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRT34 | Homo sapiens | O76011 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRT34 | Homo sapiens | O76011 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRT38 | Homo sapiens | O76015 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRT38 | Homo sapiens | O76015 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP19-5 | Homo sapiens | Q3LI72 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP19-5 | Homo sapiens | Q3LI72 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRT35 | Homo sapiens | Q92764 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRT35 | Homo sapiens | Q92764 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | REL | Homo sapiens | Q04864-2 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | REL | Homo sapiens | Q04864-2 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KPRP | Homo sapiens | Q5T749 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KPRP | Homo sapiens | Q5T749 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | FOXN1 | Homo sapiens | O15353 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | FOXN1 | Homo sapiens | O15353 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | MTUS2 | Homo sapiens | Q5JR59-3 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | MTUS2 | Homo sapiens | Q5JR59-3 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP1-5 | Homo sapiens | Q9BYS1 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP1-5 | Homo sapiens | Q9BYS1 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | TLE5 | Homo sapiens | Q08117-2 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | TLE5 | Homo sapiens | Q08117-2 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP1-3 | Homo sapiens | Q8IUG1 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP1-3 | Homo sapiens | Q8IUG1 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | ATN1 | Homo sapiens | Q86V38 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | ATN1 | Homo sapiens | Q86V38 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRT36 | Homo sapiens | O76013-2 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRT36 | Homo sapiens | O76013-2 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | SPAG8 | Homo sapiens | Q99932-2 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | SPAG8 | Homo sapiens | Q99932-2 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | LMO2 | Homo sapiens | P25791-3 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | LMO2 | Homo sapiens | P25791-3 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP1-1 | Homo sapiens | Q07627 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP1-1 | Homo sapiens | Q07627 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP6-2 | Homo sapiens | Q3LI66 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP6-2 | Homo sapiens | Q3LI66 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | ZNF438 | Homo sapiens | Q7Z4V0 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | ZNF438 | Homo sapiens | Q7Z4V0 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | USP54 | Homo sapiens | Q70EL1-9 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | USP54 | Homo sapiens | Q70EL1-9 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP5-7 | Homo sapiens | Q6L8G8 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP5-7 | Homo sapiens | Q6L8G8 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | ZMYND12 | Homo sapiens | Q9H0C1 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | ZMYND12 | Homo sapiens | Q9H0C1 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | WWOX | Homo sapiens | Q9NZC7-5 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | WWOX | Homo sapiens | Q9NZC7-5 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | WWOX | Homo sapiens | Q9NZC7-5 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | ZFY | Homo sapiens | P08048 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | ZFY | Homo sapiens | P08048 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | PRR20D | Homo sapiens | P86480 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | PRR20D | Homo sapiens | P86480 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | TSC1 | Homo sapiens | Q86WV8 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | TSC1 | Homo sapiens | Q86WV8 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | NHLRC4 | Homo sapiens | P0CG21 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | NHLRC4 | Homo sapiens | P0CG21 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | UBASH3B | Homo sapiens | Q8TF42 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | UBASH3B | Homo sapiens | Q8TF42 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP2-4 | Homo sapiens | Q9BYR9 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP2-4 | Homo sapiens | Q9BYR9 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | ASPG | Homo sapiens | Q86U10 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | ASPG | Homo sapiens | Q86U10 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | NOTCH2NLC | Homo sapiens | P0DPK4 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | NOTCH2NLC | Homo sapiens | P0DPK4 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP6-3 | Homo sapiens | Q3LI67 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP6-3 | Homo sapiens | Q3LI67 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | REL | Homo sapiens | Q04864 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | PSMA3 | Homo sapiens | P25788 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | PSME3 | Homo sapiens | P61289 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | PSME3 | Homo sapiens | P61289 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | PFDN5 | Homo sapiens | Q99471 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | PFDN5 | Homo sapiens | Q99471 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | AKAP8L | Homo sapiens | Q9ULX6 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | AKAP8L | Homo sapiens | Q9ULX6 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | AKAP8L | Homo sapiens | Q9ULX6 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP3-3 | Homo sapiens | Q9BYR6 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP3-3 | Homo sapiens | Q9BYR6 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | PRDM14 | Homo sapiens | Q9GZV8 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | PRDM14 | Homo sapiens | Q9GZV8 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP5-9 | Homo sapiens | P26371 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | TCF4 | Homo sapiens | P15884 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | OIP5 | Homo sapiens | O43482 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | OIP5 | Homo sapiens | O43482 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | MYOZ3 | Homo sapiens | Q8TDC0 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | MYOZ3 | Homo sapiens | Q8TDC0 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | RUSC1 | Homo sapiens | Q9BVN2 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | RUSC1 | Homo sapiens | Q9BVN2 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | INCA1 | Homo sapiens | Q0VD86 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | INCA1 | Homo sapiens | Q0VD86 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | INCA1 | Homo sapiens | Q0VD86 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | INCA1 | Homo sapiens | Q0VD86 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | SAT1 | Homo sapiens | P21673 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | SAT1 | Homo sapiens | P21673 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | HSF2BP | Homo sapiens | O75031 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | HSF2BP | Homo sapiens | O75031 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | CFAP68 | Homo sapiens | Q9H5F2 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | CFAP68 | Homo sapiens | Q9H5F2 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | TRIM27 | Homo sapiens | P14373 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | TRIM27 | Homo sapiens | P14373 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | TRIM27 | Homo sapiens | P14373 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | TRIM27 | Homo sapiens | P14373 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KHDRBS3 | Homo sapiens | O75525 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | MDFI | Homo sapiens | Q99750 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | MDFI | Homo sapiens | Q99750 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | MDFI | Homo sapiens | Q99750 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | MDFI | Homo sapiens | Q99750 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | FRS3 | Homo sapiens | O43559 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | FRS3 | Homo sapiens | O43559 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | PLSCR1 | Homo sapiens | O15162 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | TRIM23 | Homo sapiens | P36406 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | TRIM23 | Homo sapiens | P36406 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | TRIM23 | Homo sapiens | P36406 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | RBPMS | Homo sapiens | Q93062 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | RBPMS | Homo sapiens | Q93062 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | RBPMS | Homo sapiens | Q93062 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | FHL3 | Homo sapiens | Q13643 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | FHL3 | Homo sapiens | Q13643 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | TRIP6 | Homo sapiens | Q15654 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | PLEKHF2 | Homo sapiens | Q9H8W4 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | PLEKHF2 | Homo sapiens | Q9H8W4 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | MTUS2 | Homo sapiens | Q5JR59 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | MTUS2 | Homo sapiens | Q5JR59 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | RFX6 | Homo sapiens | Q8HWS3 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | RFX6 | Homo sapiens | Q8HWS3 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | GRN | Homo sapiens | P28799 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | GRN | Homo sapiens | P28799 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | CCNDBP1 | Homo sapiens | O95273 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | FHL5 | Homo sapiens | Q5TD97 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | FHL5 | Homo sapiens | Q5TD97 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | LASP1 | Homo sapiens | Q14847-2 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | LASP1 | Homo sapiens | Q14847-2 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | NOTCH2NLA | Homo sapiens | Q7Z3S9 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | NOTCH2NLA | Homo sapiens | Q7Z3S9 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | NOTCH2NLA | Homo sapiens | Q7Z3S9 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRT31 | Homo sapiens | Q15323 | 25416956 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRT31 | Homo sapiens | Q15323 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRT31 | Homo sapiens | Q15323 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | ATP6V0D1 | Homo sapiens | P61421 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | ATP6V0D1 | Homo sapiens | P61421 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP3-1 | Homo sapiens | Q9BYR8 | 32296183 | |
|
Intra
|
DMRT3 | Q9NQL9 | KRTAP3-1 | Homo sapiens | Q9BYR8 | 32296183 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| 46,Xy Partial Gonadal Dysgenesis |
|
|
| Gonadoblastoma |
|
|
| Premature Menopause |
|
|
| Spermatogenic Failure 8 |
|
|
| Chromosome 9p Deletion Syndrome |
|
|
| Cerebral Palsy |
|
|
| Spermatocytoma |
|
|
| Croup |
|
|
| 46,Xy Sex Reversal |
|
|
| Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | DMRT3 | RGD | RGD:1306043 |
| Bos taurus | DMRT3 | VGNC | VGNC:28112 |
| Felis catus | DMRT3 | VGNC | VGNC:102919 |
| Canis familiaris | DMRT3 | VGNC | VGNC:49682 |
| Mus musculus | DMRT3 | MGD | MGI:2449470 |
| Others | DMRT3 | NCBI |