DMRT3 - doublesex and mab-3 related transcription factor 3 Gene

Also Known as DMRTA3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 58524

About DMRT3

Cytogenetic location: 9p24.3 Genomic coordinates (GRCh38): 9:976,655-991,732 (from NCBI)

This gene has 2 transcripts (splice variants), 190 orthologues, 8 paralogues and is associated with 1 phenotype. Biased expression in thyroid (RPKM 4.6), testis (RPKM 2.6) and 2 other tissues.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in male sex differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including adult walking behavior; transmission of nerve impulse; and ventral spinal cord interneuron specification. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

DMRT3 Products (1)

mRNA Protein Name
NM_021240.4 NP_067063.1 doublesex- and mab-3-related transcription factor 3
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DMRT3 Protein Structure

DM

DM: DM DNA binding domain (25 - 71)

DMA

DMA: DMRTA motif (248 - 286)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 472 a.a.
Protein Preferred Names Protein Names

doublesex- and mab-3-related transcription factor 3

  • DMRT-like family A3

DMRT3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DMRT3 Q9NQL9 KRT40 Homo sapiens Q6A162 32296183
Intra
DMRT3 Q9NQL9 KRT40 Homo sapiens Q6A162 25416956
Intra
DMRT3 Q9NQL9 KRT40 Homo sapiens Q6A162 25416956
Intra
DMRT3 Q9NQL9 KRT40 Homo sapiens Q6A162 32296183
Intra
DMRT3 Q9NQL9 KRTAP10-8 Homo sapiens P60410 25416956
Intra
DMRT3 Q9NQL9 KRTAP10-8 Homo sapiens P60410 32296183
Intra
DMRT3 Q9NQL9 KRTAP10-8 Homo sapiens P60410 32296183
Intra
DMRT3 Q9NQL9 KRTAP10-8 Homo sapiens P60410 25416956
Intra
DMRT3 Q9NQL9 KRTAP10-8 Homo sapiens P60410 25416956
Intra
DMRT3 Q9NQL9 KRTAP10-9 Homo sapiens P60411 32296183
Intra
DMRT3 Q9NQL9 KRTAP10-9 Homo sapiens P60411 32296183
Intra
DMRT3 Q9NQL9 KRTAP10-9 Homo sapiens P60411 25416956
Intra
DMRT3 Q9NQL9 MID2 Homo sapiens Q9UJV3-2 32296183
Intra
DMRT3 Q9NQL9 MID2 Homo sapiens Q9UJV3-2 25416956
Intra
DMRT3 Q9NQL9 MID2 Homo sapiens Q9UJV3-2 32296183
Intra
DMRT3 Q9NQL9 MID2 Homo sapiens Q9UJV3-2 32296183
Intra
DMRT3 Q9NQL9 GPSM1 Homo sapiens Q86YR5-3 32296183
Intra
DMRT3 Q9NQL9 GPSM1 Homo sapiens Q86YR5-3 32296183
Intra
DMRT3 Q9NQL9 NFKBID Homo sapiens Q8NI38 32296183
Intra
DMRT3 Q9NQL9 NFKBID Homo sapiens Q8NI38 32296183
Intra
DMRT3 Q9NQL9 KRTAP9-3 Homo sapiens Q9BYQ3 32296183
Intra
DMRT3 Q9NQL9 KRTAP9-3 Homo sapiens Q9BYQ3 32296183
Intra
DMRT3 Q9NQL9 KRTAP9-2 Homo sapiens Q9BYQ4 32296183
Intra
DMRT3 Q9NQL9 KRTAP9-2 Homo sapiens Q9BYQ4 32296183
Intra
DMRT3 Q9NQL9 KRT34 Homo sapiens O76011 32296183
Intra
DMRT3 Q9NQL9 KRT34 Homo sapiens O76011 32296183
Intra
DMRT3 Q9NQL9 KRT38 Homo sapiens O76015 32296183
Intra
DMRT3 Q9NQL9 KRT38 Homo sapiens O76015 32296183
Intra
DMRT3 Q9NQL9 KRTAP19-5 Homo sapiens Q3LI72 32296183
Intra
DMRT3 Q9NQL9 KRTAP19-5 Homo sapiens Q3LI72 32296183
Intra
DMRT3 Q9NQL9 KRT35 Homo sapiens Q92764 32296183
Intra
DMRT3 Q9NQL9 KRT35 Homo sapiens Q92764 32296183
Intra
DMRT3 Q9NQL9 REL Homo sapiens Q04864-2 32296183
Intra
DMRT3 Q9NQL9 REL Homo sapiens Q04864-2 32296183
Intra
DMRT3 Q9NQL9 KPRP Homo sapiens Q5T749 32296183
Intra
DMRT3 Q9NQL9 KPRP Homo sapiens Q5T749 32296183
Intra
DMRT3 Q9NQL9 FOXN1 Homo sapiens O15353 32296183
Intra
DMRT3 Q9NQL9 FOXN1 Homo sapiens O15353 32296183
Intra
DMRT3 Q9NQL9 MTUS2 Homo sapiens Q5JR59-3 32296183
Intra
DMRT3 Q9NQL9 MTUS2 Homo sapiens Q5JR59-3 32296183
Intra
DMRT3 Q9NQL9 KRTAP1-5 Homo sapiens Q9BYS1 32296183
Intra
DMRT3 Q9NQL9 KRTAP1-5 Homo sapiens Q9BYS1 32296183
Intra
DMRT3 Q9NQL9 TLE5 Homo sapiens Q08117-2 32296183
Intra
DMRT3 Q9NQL9 TLE5 Homo sapiens Q08117-2 32296183
Intra
DMRT3 Q9NQL9 KRTAP1-3 Homo sapiens Q8IUG1 32296183
Intra
DMRT3 Q9NQL9 KRTAP1-3 Homo sapiens Q8IUG1 32296183
Intra
DMRT3 Q9NQL9 ATN1 Homo sapiens Q86V38 32296183
Intra
DMRT3 Q9NQL9 ATN1 Homo sapiens Q86V38 32296183
Intra
DMRT3 Q9NQL9 KRT36 Homo sapiens O76013-2 32296183
Intra
DMRT3 Q9NQL9 KRT36 Homo sapiens O76013-2 32296183
Intra
DMRT3 Q9NQL9 SPAG8 Homo sapiens Q99932-2 32296183
Intra
DMRT3 Q9NQL9 SPAG8 Homo sapiens Q99932-2 32296183
Intra
DMRT3 Q9NQL9 LMO2 Homo sapiens P25791-3 32296183
Intra
DMRT3 Q9NQL9 LMO2 Homo sapiens P25791-3 32296183
Intra
DMRT3 Q9NQL9 KRTAP1-1 Homo sapiens Q07627 32296183
Intra
DMRT3 Q9NQL9 KRTAP1-1 Homo sapiens Q07627 32296183
Intra
DMRT3 Q9NQL9 KRTAP6-2 Homo sapiens Q3LI66 32296183
Intra
DMRT3 Q9NQL9 KRTAP6-2 Homo sapiens Q3LI66 32296183
Intra
DMRT3 Q9NQL9 ZNF438 Homo sapiens Q7Z4V0 32296183
Intra
DMRT3 Q9NQL9 ZNF438 Homo sapiens Q7Z4V0 32296183
Intra
DMRT3 Q9NQL9 USP54 Homo sapiens Q70EL1-9 32296183
Intra
DMRT3 Q9NQL9 USP54 Homo sapiens Q70EL1-9 32296183
Intra
DMRT3 Q9NQL9 KRTAP5-7 Homo sapiens Q6L8G8 32296183
Intra
DMRT3 Q9NQL9 KRTAP5-7 Homo sapiens Q6L8G8 32296183
Intra
DMRT3 Q9NQL9 ZMYND12 Homo sapiens Q9H0C1 32296183
Intra
DMRT3 Q9NQL9 ZMYND12 Homo sapiens Q9H0C1 32296183
Intra
DMRT3 Q9NQL9 WWOX Homo sapiens Q9NZC7-5 32296183
Intra
DMRT3 Q9NQL9 WWOX Homo sapiens Q9NZC7-5 32296183
Intra
DMRT3 Q9NQL9 WWOX Homo sapiens Q9NZC7-5 32296183
Intra
DMRT3 Q9NQL9 ZFY Homo sapiens P08048 32296183
Intra
DMRT3 Q9NQL9 ZFY Homo sapiens P08048 32296183
Intra
DMRT3 Q9NQL9 PRR20D Homo sapiens P86480 32296183
Intra
DMRT3 Q9NQL9 PRR20D Homo sapiens P86480 32296183
Intra
DMRT3 Q9NQL9 TSC1 Homo sapiens Q86WV8 32296183
Intra
DMRT3 Q9NQL9 TSC1 Homo sapiens Q86WV8 32296183
Intra
DMRT3 Q9NQL9 NHLRC4 Homo sapiens P0CG21 32296183
Intra
DMRT3 Q9NQL9 NHLRC4 Homo sapiens P0CG21 32296183
Intra
DMRT3 Q9NQL9 UBASH3B Homo sapiens Q8TF42 25416956
Intra
DMRT3 Q9NQL9 UBASH3B Homo sapiens Q8TF42 25416956
Intra
DMRT3 Q9NQL9 KRTAP2-4 Homo sapiens Q9BYR9 32296183
Intra
DMRT3 Q9NQL9 KRTAP2-4 Homo sapiens Q9BYR9 32296183
Intra
DMRT3 Q9NQL9 MEOX2 Homo sapiens Q6FHY5 32296183
Intra
DMRT3 Q9NQL9 MEOX2 Homo sapiens Q6FHY5 32296183
Intra
DMRT3 Q9NQL9 ASPG Homo sapiens Q86U10 32296183
Intra
DMRT3 Q9NQL9 ASPG Homo sapiens Q86U10 32296183
Intra
DMRT3 Q9NQL9 NOTCH2NLC Homo sapiens P0DPK4 32296183
Intra
DMRT3 Q9NQL9 NOTCH2NLC Homo sapiens P0DPK4 32296183
Intra
DMRT3 Q9NQL9 KRTAP6-3 Homo sapiens Q3LI67 32296183
Intra
DMRT3 Q9NQL9 KRTAP6-3 Homo sapiens Q3LI67 32296183
Intra
DMRT3 Q9NQL9 REL Homo sapiens Q04864 25416956
Intra
DMRT3 Q9NQL9 PSMA3 Homo sapiens P25788 25416956
Intra
DMRT3 Q9NQL9 PSME3 Homo sapiens P61289 32296183
Intra
DMRT3 Q9NQL9 PSME3 Homo sapiens P61289 32296183
Intra
DMRT3 Q9NQL9 PFDN5 Homo sapiens Q99471 32296183
Intra
DMRT3 Q9NQL9 PFDN5 Homo sapiens Q99471 32296183
Intra
DMRT3 Q9NQL9 AKAP8L Homo sapiens Q9ULX6 32296183
Intra
DMRT3 Q9NQL9 AKAP8L Homo sapiens Q9ULX6 32296183
Intra
DMRT3 Q9NQL9 AKAP8L Homo sapiens Q9ULX6 32296183
Intra
DMRT3 Q9NQL9 CYSRT1 Homo sapiens A8MQ03 32296183
Intra
DMRT3 Q9NQL9 CYSRT1 Homo sapiens A8MQ03 32296183
Intra
DMRT3 Q9NQL9 KRTAP3-3 Homo sapiens Q9BYR6 32296183
Intra
DMRT3 Q9NQL9 KRTAP3-3 Homo sapiens Q9BYR6 32296183
Intra
DMRT3 Q9NQL9 PRDM14 Homo sapiens Q9GZV8 32296183
Intra
DMRT3 Q9NQL9 PRDM14 Homo sapiens Q9GZV8 32296183
Intra
DMRT3 Q9NQL9 KRTAP5-9 Homo sapiens P26371 25416956
Intra
DMRT3 Q9NQL9 TCF4 Homo sapiens P15884 25416956
Intra
DMRT3 Q9NQL9 OIP5 Homo sapiens O43482 32296183
Intra
DMRT3 Q9NQL9 OIP5 Homo sapiens O43482 32296183
Intra
DMRT3 Q9NQL9 MYOZ3 Homo sapiens Q8TDC0 32296183
Intra
DMRT3 Q9NQL9 MYOZ3 Homo sapiens Q8TDC0 32296183
Intra
DMRT3 Q9NQL9 RUSC1 Homo sapiens Q9BVN2 32296183
Intra
DMRT3 Q9NQL9 RUSC1 Homo sapiens Q9BVN2 32296183
Intra
DMRT3 Q9NQL9 INCA1 Homo sapiens Q0VD86 32296183
Intra
DMRT3 Q9NQL9 INCA1 Homo sapiens Q0VD86 25416956
Intra
DMRT3 Q9NQL9 INCA1 Homo sapiens Q0VD86 32296183
Intra
DMRT3 Q9NQL9 INCA1 Homo sapiens Q0VD86 25416956
Intra
DMRT3 Q9NQL9 SAT1 Homo sapiens P21673 25416956
Intra
DMRT3 Q9NQL9 SAT1 Homo sapiens P21673 25416956
Intra
DMRT3 Q9NQL9 HSF2BP Homo sapiens O75031 32296183
Intra
DMRT3 Q9NQL9 HSF2BP Homo sapiens O75031 32296183
Intra
DMRT3 Q9NQL9 CFAP68 Homo sapiens Q9H5F2 32296183
Intra
DMRT3 Q9NQL9 CFAP68 Homo sapiens Q9H5F2 32296183
Intra
DMRT3 Q9NQL9 TRIM27 Homo sapiens P14373 25416956
Intra
DMRT3 Q9NQL9 TRIM27 Homo sapiens P14373 25416956
Intra
DMRT3 Q9NQL9 TRIM27 Homo sapiens P14373 32296183
Intra
DMRT3 Q9NQL9 TRIM27 Homo sapiens P14373 32296183
Intra
DMRT3 Q9NQL9 KHDRBS3 Homo sapiens O75525 25416956
Intra
DMRT3 Q9NQL9 MDFI Homo sapiens Q99750 25416956
Intra
DMRT3 Q9NQL9 MDFI Homo sapiens Q99750 32296183
Intra
DMRT3 Q9NQL9 MDFI Homo sapiens Q99750 25416956
Intra
DMRT3 Q9NQL9 MDFI Homo sapiens Q99750 32296183
Intra
DMRT3 Q9NQL9 FRS3 Homo sapiens O43559 32296183
Intra
DMRT3 Q9NQL9 FRS3 Homo sapiens O43559 32296183
Intra
DMRT3 Q9NQL9 PLSCR1 Homo sapiens O15162 25416956
Intra
DMRT3 Q9NQL9 TRIM23 Homo sapiens P36406 25416956
Intra
DMRT3 Q9NQL9 TRIM23 Homo sapiens P36406 25416956
Intra
DMRT3 Q9NQL9 TRIM23 Homo sapiens P36406 25416956
Intra
DMRT3 Q9NQL9 RBPMS Homo sapiens Q93062 25416956
Intra
DMRT3 Q9NQL9 RBPMS Homo sapiens Q93062 25416956
Intra
DMRT3 Q9NQL9 RBPMS Homo sapiens Q93062 25416956
Intra
DMRT3 Q9NQL9 FHL3 Homo sapiens Q13643 32296183
Intra
DMRT3 Q9NQL9 FHL3 Homo sapiens Q13643 32296183
Intra
DMRT3 Q9NQL9 TRIP6 Homo sapiens Q15654 25416956
Intra
DMRT3 Q9NQL9 PLEKHF2 Homo sapiens Q9H8W4 32296183
Intra
DMRT3 Q9NQL9 PLEKHF2 Homo sapiens Q9H8W4 32296183
Intra
DMRT3 Q9NQL9 MTUS2 Homo sapiens Q5JR59 25416956
Intra
DMRT3 Q9NQL9 MTUS2 Homo sapiens Q5JR59 25416956
Intra
DMRT3 Q9NQL9 RFX6 Homo sapiens Q8HWS3 32296183
Intra
DMRT3 Q9NQL9 RFX6 Homo sapiens Q8HWS3 32296183
Intra
DMRT3 Q9NQL9 GRN Homo sapiens P28799 32296183
Intra
DMRT3 Q9NQL9 GRN Homo sapiens P28799 32296183
Intra
DMRT3 Q9NQL9 CCNDBP1 Homo sapiens O95273 25416956
Intra
DMRT3 Q9NQL9 FHL5 Homo sapiens Q5TD97 32296183
Intra
DMRT3 Q9NQL9 FHL5 Homo sapiens Q5TD97 32296183
Intra
DMRT3 Q9NQL9 LASP1 Homo sapiens Q14847-2 32296183
Intra
DMRT3 Q9NQL9 LASP1 Homo sapiens Q14847-2 32296183
Intra
DMRT3 Q9NQL9 NOTCH2NLA Homo sapiens Q7Z3S9 25416956
Intra
DMRT3 Q9NQL9 NOTCH2NLA Homo sapiens Q7Z3S9 25416956
Intra
DMRT3 Q9NQL9 NOTCH2NLA Homo sapiens Q7Z3S9 25416956
Intra
DMRT3 Q9NQL9 KRT31 Homo sapiens Q15323 25416956
Intra
DMRT3 Q9NQL9 KRT31 Homo sapiens Q15323 32296183
Intra
DMRT3 Q9NQL9 KRT31 Homo sapiens Q15323 32296183
Intra
DMRT3 Q9NQL9 ATP6V0D1 Homo sapiens P61421 32296183
Intra
DMRT3 Q9NQL9 ATP6V0D1 Homo sapiens P61421 32296183
Intra
DMRT3 Q9NQL9 KRTAP3-1 Homo sapiens Q9BYR8 32296183
Intra
DMRT3 Q9NQL9 KRTAP3-1 Homo sapiens Q9BYR8 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
46,Xy Partial Gonadal Dysgenesis
  • 46,Xy Pgd

  • 46,Xy Partial Testicular Dysgenesis

Gonadoblastoma
  • GBY

Premature Menopause
  • Primary Ovarian Insufficiency

  • Premature Ovarian Failure

  • Hypergonadotropic Hypogonadism

  • Premature Ovarian Insufficiency

  • Menopause - Premature

  • Menopause Praecox

  • Menopause Premature

  • Menopause, Premature

  • Female Hypergonadotropic Hypogonadism

  • Hypergonadotrophic Ovarian Failure

  • Primary Female Hypogonadism

  • Pof - [Premature Ovarian Failure]

  • Ovarian Failure

  • Ovarian Secretion Suppression

  • Ovary Hyposecretion

  • Ovary Secretion Deficiency

  • Premature Menopause Nos

Spermatogenic Failure 8
  • SPGF8

Chromosome 9p Deletion Syndrome
  • Monosomy 9p

  • Monosomy 9p Syndrome

  • Alfi Syndrome

  • 9p Syndrome

  • Chromosome 9p Deletion

  • 9p Deletion

  • 9p Monosomy

  • Deletion 9p

  • Partial Monosomy 9p

  • 9p Deletion Syndrome

  • 9p- Syndrome

  • Alfi'S Syndrome

  • Chromosome 9, Partial Trisomy 9p

Cerebral Palsy
  • Infantile Cerebral Palsy

  • Mixed Cerebral Palsy

  • Palsy Cerebral

  • Palsy, Cerebral

  • Cerebral Palsy, Mixed

Spermatocytoma
  • Spermatocytic Seminoma

Croup
  • Acute Obstructive Laryngitis

  • Laryngotracheobronchitis

  • Acute Laryngotracheobronchitis

  • Croup Syndrome

  • Acute Laryngitis With Obstruction

  • Obstructive Laryngitis

  • Obstructive Laryngitis Nos

  • Obstructive Laryngotracheitis Nos

46,Xy Sex Reversal
  • Swyer Syndrome

  • Pure Gonadal Dysgenesis 46,Xy

  • Gonadal Dysgenesis, Xy Female Type

  • Gonadal Dysgenesis, 46,Xy

  • 46,Xy Cgd

  • 46,Xy Complete Gonadal Dysgenesis

  • 46,Xy Pure Gonadal Dysgenesis

  • 46 Xy Gonadal Dysgenesis

  • 46, Xy Cgd

  • 46, Xy Complete Gonadal Dysgenesis

  • 46, Xy Pure Gonadal Dysgenesis

  • Xy Pure Gonadal Dysgenesis

  • Female With 46,Xy Karyotype

  • Xy Females

Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome
  • Wagr Syndrome

  • 11p Partial Monosomy Syndrome

  • Chromosome 11p13 Deletion Syndrome

  • Wilms Tumor, Aniridia, Genitourinary Anomalies And Mental Retardation Syndrome

  • 11p Deletion Syndrome

  • Chromosome 11p Deletion Syndrome

  • Wagr Complex

  • Wilms Tumor-Aniridia-Genitourinary Anomalies-Intellectual Disability Syndrome

  • Deletion 11p13

  • WAGR

  • Wilms Tumor-Aniridia-Genitourinary Anomalies-Mental Retardation Syndrome

  • Chromosome 11p Deletion

  • 11p Deletion

  • 11p Monosomy

  • Deletion 11p

  • Monosomy 11p

  • Partial Monosomy 11p

  • Agr Triad

  • Wilms Tumor-Aniridia-Gonadoblastoma-Mental Retardation Syndrome

  • Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation Syndrome

  • Wagr Contiguous Gene Syndrome

  • Wilms Tumor-Aniridia-Genital Anomalies-Retardation Syndrome

  • Wilms Tumor-Aniridia-Genitourinary Anomalies-Mr Syndrome

  • Del(11)(P13)

  • Monosomy 11p13

  • Chromosome 11, Deletion 11p

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DMRT3 RGD RGD:1306043
Bos taurus DMRT3 VGNC VGNC:28112
Felis catus DMRT3 VGNC VGNC:102919
Canis familiaris DMRT3 VGNC VGNC:49682
Mus musculus DMRT3 MGD MGI:2449470
Others DMRT3 NCBI