FOXN1 - forkhead box N1 Gene

Also Known as WHN; RONU; TLIND; FKHL20; TIDAND

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8456

About FOXN1

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,506,348-28,538,900 (from NCBI)

This gene has 3 transcripts (splice variants), 195 orthologues, 42 paralogues and is associated with 4 phenotypes. Biased expression in skin (RPKM 9.7) and esophagus (RPKM 2.5).

Summary

Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008]

FOXN1 Products (2)

mRNA	Protein	Name
NM_001369369.1	NP_001356298.1	forkhead box protein N1
NM_003593.3	NP_003584.2	forkhead box protein N1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of epithelial cell differentiation	IDA IDA: Inferred from direct assay	24383669	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXN1 Protein Structure

Forkhead

0
100
200
300
400
500
600
648 a.a.

Protein Preferred Names	Protein Names
forkhead box protein N1	Rowett nude

FOXN1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FOXN1	O15353	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	FOXN1	O15353	SPATC1L	Homo sapiens	Q9H0A9-2	Validated Y2H	32296183
Intra	FOXN1	O15353	TRAF2	Homo sapiens	Q12933	Validated Y2H	32296183
Intra	FOXN1	O15353	CDC23	Homo sapiens	Q9UJX2	Validated Y2H	32296183
Intra	FOXN1	O15353	TSSK1B	Homo sapiens	Q9BXA7	MAPPIT	32296183
Intra	FOXN1	O15353	TSSK1B	Homo sapiens	Q9BXA7	Validated Y2H	32296183
Intra	FOXN1	O15353	PIN1	Homo sapiens	Q13526	Validated Y2H	32296183
Intra	FOXN1	O15353	HOXA1	Homo sapiens	P49639	Validated Y2H	32296183
Intra	FOXN1	O15353	TRAPPC6A	Homo sapiens	O75865-2	Validated Y2H	32296183
Intra	FOXN1	O15353	LHX8	Homo sapiens	Q68G74	Validated Y2H	32296183
Intra	FOXN1	O15353	CDA	Homo sapiens	P32320	Validated Y2H	32296183
Intra	FOXN1	O15353	MAPKBP1	Homo sapiens	O60336	Validated Y2H	32296183
Intra	FOXN1	O15353	DMRT3	Homo sapiens	Q9NQL9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

FOXN1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811367	FOXN1 Antibody	WB, IHC-P, IHC-F, FC, IF-Tissue	Human, Mouse, Rat

Related Diseases

Diseases	Alias
T-Cell Immunodeficiency, Congenital Alopecia, And Nail Dystrophy	Winged Helix Deficiency Alymphoid Cystic Thymic Dysgenesis Severe T-Cell Immunodeficiency-Congenital Alopecia-Nail Dystrophy Syndrome Pignata Guarino Syndrome TIDAND T-Cell Immunodeficiency, Congenital Alopecia And Nail Dystrophy Congenital Alopecia And Nail Dystrophy Associated With Severe Functional T-Cell Immunodeficiency Severe Combined Immunodeficiency Due To Foxn1 Deficiency Foxn1 Deficiency Nude/Scid Nude/Severe Combined Immunodeficiency Scid Due To Foxn1 Deficiency Severe T-Cell Immunodeficiency-Congenital Alopecia-Nail Dystrophy
T-Cell Lymphopenia, Infantile, With Or Without Nail Dystrophy, Autosomal Dominant	TLIND T-Cell Lymphopenia, Infantile, Without Nail Dystrophy, Autosomal Dominant
T-Cell Immunodeficiency With Thymic Aplasia	Nezelof Syndrome T-Lymphocyte Deficiency TIDTA Immune Defect Due To Absence Of Thymus Thymic Aplasia Nezelof'S Syndrome Thymic Dysplasia With Normal Immunoglobulins Thymic Aplasia Syndrome T-Lymphocyte Immunodeficiency
Alopecia
Lymphopenia	Lymphocytopenia
Ectopic Thymus
Thymus Squamous Cell Carcinoma	Epidermoid Thymic Carcinoma Thymic Squamous Cell Carcinoma
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Thymic Dysplasia
Disseminated Chorioretinitis
Anencephaly	Aprosencephaly Anencephalus Congenital Absence Of Brain Absence Of A Large Part Of The Brain And The Skull Anencephalia Anencephalic Monster Brain Absence Brain Agenesis Brain Aplasia Absent Brain Anencephalic Congenital Absence Of Cerebrum Congenital Hemicrania Incomplete Anencephaly
T Cell Deficiency	T Cell Immunodeficiency T Lymphocyte Deficiency T Lymphocyte Immunodeficiency T-Lymphocyte Deficiency
Fraser Syndrome 1	Fraser Syndrome Cryptophthalmos With Other Malformations Cryptophthalmos Syndrome FRASRS1 Cryptophthalmos-Syndactyly Syndrome Fraser-Francois Syndrome Cyclopism Meyer-Schwickerath'S Syndrome Ulrich-Feichtiger Syndrome Cryptophthalmos Syndactyly Syndrome Fraser'S Syndrome Meyer-Schwickerath Syndrome Ullrich-Feichtiger Syndrome
Ectodermal Dysplasia 9, Hair/Nail Type	ECTD9 Ectodermal Dysplasia 9 Dysplasia, Ectodermal, Type 9, Hair/Nail
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Alopecia Universalis Congenita	Alopecia Universalis ALUNC Atrichia, Generalized Au Alopecia Areata Universalis Atrichia Generalized
Atrichia With Papular Lesions	Papular Atrichia APL Congenital Atrichia
Ectodermal Dysplasia 5, Hair/Nail Type	ECTD5 Ectodermal Dysplasia 5
Ectodermal Dysplasia 6, Hair/Nail Type	ECTD6 Ectodermal Dysplasia 6
Ectodermal Dysplasia 7, Hair/Nail Type	ECTD7 Ectodermal Dysplasia 7 Dysplasia, Ectodermal, Type 7, Hair/Nail
Hair Disease	Hair Diseases Hair Anomaly Hair Disorder Hair Problems
Ectodermal Dysplasia 4, Hair/Nail Type	Pure Hair And Nail Ectodermal Dysplasia ECTD4 Ectodermal Dysplasia, Pure Hair-Nail Type Ectodermal Dysplasia, 'Pure' Hair/Nail Type Hned Hair-Nail Ectodermal Dysplasia Phned Ectodermal Dysplasia Pure Hair-Nail Type Ectodermal Dysplasia, 'Pure' Hair-Nail Type Dysplasia, Ectodermal, Type 4, Hair/Nail
Keratosis, Seborrheic	Seborrheic Keratosis Keratosis, Seborrheic, Somatic Basal Cell Papilloma Keratosis Seborrheica KERSEB
Hypotrichosis 2	HYPT2 Hypotrichosis Simplex Of The Scalp 1 Htss1 Htss Hypotrichosis, Spanish Type Spanish Type Hypotrichosis Hypotrichosis Spanish Type Hypotrichosis, Type 2 Hypotrichosis Simplex Of Scalp
Acanthoma
Cutaneous Ganglioneuroma	Ganglioneuroma Of Skin
Omenn Syndrome	Histiocytic Medullary Reticulosis Severe Combined Immunodeficiency With Hypereosinophilia Combined Immunodeficiency With Hypereosinophilia Reticuloendotheliosis, Familial, With Eosinophilia Reticuloendotheliosis Familial With Eosinophilia Familial Reticuloendotheliosis Omenn'S Syndrome OS Malignant Histiocytosis
Monilethrix	Beaded Hair MNLIX Nodose Hair Moniliform Hair Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05065	FOXN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FOXN1	VGNC	VGNC:40960
Bos taurus	FOXN1	VGNC	VGNC:29095
Macaca mulatta	FOXN1	VGNC	VGNC:72481
Mus musculus	FOXN1	MGD	MGI:102949
Felis catus	FOXN1	VGNC	VGNC:62340
Rattus norvegicus	FOXN1	RGD	RGD:3970
Others	FOXN1	NCBI