CDA - cytidine deaminase Gene

Also Known as CDD

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 978

About CDA

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:20,589,097-20,618,903 (from NCBI)

This gene has 2 transcripts (splice variants) and 239 orthologues. Biased expression in bone marrow (RPKM 57.6), esophagus (RPKM 22.6) and 8 other tissues.

Summary

This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008]

CDA Products (1)

mRNA	Protein	Name
NM_001785.3	NP_001776.1	cytidine deaminase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cytidine deaminase activity	IDA IDA: Inferred from direct assay	7923172	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	9596658	GOA
enables nucleoside binding	IDA IDA: Inferred from direct assay	15689149	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	15689149	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	15689149	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cytidine deamination	IDA IDA: Inferred from direct assay	9596658	GOA
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	9596658	GOA
involved in negative regulation of nucleotide metabolic process	IDA IDA: Inferred from direct assay	9596658	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	9596658	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDA Protein Structure

dCMP_cyt_deam_1

0
100
146 a.a.

Protein Preferred Names	Protein Names
cytidine deaminase	cytidine aminohydrolase

CDA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDA	P32320	PTGER3	Homo sapiens	P43115-12	Y2H Prey Pooling	25416956
Intra	CDA	P32320	KRTAP8-1	Homo sapiens	Q8IUC2	Validated Y2H	32296183
Intra	CDA	P32320	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Array	32296183
Intra	CDA	P32320	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Prey Pooling	32296183
Intra	CDA	P32320	FOXN1	Homo sapiens	O15353	Y2H Prey Pooling	32296183
Intra	CDA	P32320	FOXN1	Homo sapiens	O15353	Y2H Array	32296183
Intra	CDA	P32320	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Prey Pooling	32296183
Intra	CDA	P32320	KRTAP6-1	Homo sapiens	Q3LI64	Validated Y2H	32296183
Intra	CDA	P32320	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Array	32296183
Intra	CDA	P32320	ARRDC3	Homo sapiens	Q96B67	Y2H Prey Pooling	32296183
Intra	CDA	P32320	ARRDC3	Homo sapiens	Q96B67	Validated Y2H	32296183
Intra	CDA	P32320	ARRDC3	Homo sapiens	Q96B67	Y2H Array	32296183
Intra	CDA	P32320	PSMA1	Homo sapiens	P25786	Validated Y2H	25416956
Intra	CDA	P32320	PLEKHB2	Homo sapiens	Q96CS7	Validated Y2H	32296183
Intra	CDA	P32320	PLEKHB2	Homo sapiens	Q96CS7	Validated Y2H	25416956
Intra	CDA	P32320	ADAT3	Homo sapiens	Q96EY9	Validated Y2H	32296183
Intra	CDA	P32320	INCA1	Homo sapiens	Q0VD86	Validated Y2H	32296183
Intra	CDA	P32320	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	CDA	P32320	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	CDA	P32320	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
Intra	CDA	P32320	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	CDA	P32320	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	25910212
Intra	CDA	P32320	LNX1	Homo sapiens	Q8TBB1	Y2H Array	25910212
Intra	CDA	P32320	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	CDA	P32320	LNX1	Homo sapiens	Q8TBB1	Y2H Array	25416956
Intra	CDA	P32320	LNX1	Homo sapiens	Q8TBB1	Y2H Bait-Prey Pool	25910212
Intra	CDA	P32320	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	31515488
Intra	CDA	P32320	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	CDA	P32320	NTAQ1	Homo sapiens	Q96HA8	Y2H Prey Pooling	25416956
Intra	CDA	P32320	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	25416956
Intra	CDA	P32320	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	CDA	P32320	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	CDA	P32320	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	CDA	P32320	ZBTB24	Homo sapiens	O43167	Validated Y2H	25416956
Intra	CDA	P32320	ZBTB24	Homo sapiens	O43167	Y2H Array	25416956
Intra	CDA	P32320	ZBTB24	Homo sapiens	O43167	Y2H Prey Pooling	25416956
Intra	CDA	P32320	FNDC11	Homo sapiens	Q9BVV2	Y2H Prey Pooling	25416956
Intra	CDA	P32320	FNDC11	Homo sapiens	Q9BVV2	Validated Y2H	32296183
Intra	CDA	P32320	FNDC11	Homo sapiens	Q9BVV2	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

CDA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81403	CDA Antibody (YA1148)	IHC-P	Human
HY-P81403A	CDA Antibody (YA1148)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Acute Leukemia	Stem Cell Leukaemia Stem Cell Leukemia Acute Leukemias Acute Undifferentiated Leukemia Undifferentiated Leukemia Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission Blast Cell Leukaemia Blast Leukaemia Blastic Leukaemia Undifferentiated Leukaemia
Immunodeficiency With Hyper-Igm, Type 2	HIGM2 Hyper-Igm Syndrome Type 2 Hyper-Igm Syndrome 2 Immunodeficiency With Hyper-Igm Type 2 Activation-Induced Cytidine Deaminase Deficiency Aid Deficiency Immunodeficiency With Hyper Igm Type 2 Hyper Igm Syndrome 2 Immunodeficiency With Hyper-Igm 2 Hyper-Igm Immunodeficiency Type 2 Immunodeficiency, With Hyper Igm, Type 2 Hyper-Igm Immunodeficiency Syndrome, Type 2
Hematologic Cancer	Hematologic Neoplasm Hematologic Neoplasms Hematologic Malignancies Blood Cancer Hematologic Malignancy Hematological Tumors Hematopoietic And Lymphoid System Tumor Hematopoietic Cancer Hematopoietic Neoplasm Hematopoietic Tumors Malignant Hematopoietic Neoplasm Liquid Tumor Hematopoietic Neoplasms
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-13599	Cladribine	99.96%	Yes
HY-109081	Cedazuridine	99.72%	Unkown
HY-109081A	Cedazuridine hydrochloride	/	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12885A	2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt	Activator	99.91%	Phase 2
HY-12885B	2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt	Activator	99.89%	Phase 2
HY-12885	2’3’-c-di-AM(PS)2 (Rp,Rp)	Activator	99.85%	Phase 2
HY-15345A	Tetrahydrouridine	Inhibitor	99.91%	Phase 2

Pre-clinical Phase

Bioactive Molecules (18)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15345	Tetrahydrouridine dihydrate	Inhibitor	99.86%	Yes
HY-12885C	2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt	Inducer	98.94%	Unkown
HY-Y1058	Benzohydroxamic acid	Inhibitor	99.95%	Unkown
HY-13599S3	Cladribine-13C3,15N3		/	Unkown
HY-13599S4	Cladribine-13C,15N2		/	Unkown
HY-15345AS	Tetrahydrouridine-d3		/	Unkown
HY-171540	AnCDA-IN-1	Inhibitor	/	Unkown
HY-171541	CDA-IN-1	Inhibitor	/	Unkown
HY-171542	CDA-IN-2	Inhibitor	/	Unkown
HY-172523	CDA-IN-3		/	Unkown
HY-RS02282	CDA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-13599S	Cladribine-d4		/	Unkown
HY-13599S1	Cladribine-13C5,15N2		/	Unkown
HY-13599S2	Cladribine-15N		/	Unkown
HY-173448	CDA-IN-4	Inhibitor	/	Unkown
HY-181002	CDA-IN-5	Inhibitor	/	Unkown
HY-RS17118	Cda Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23563	Cda Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CDA	VGNC	VGNC:38983
Bos taurus	CDA	VGNC	VGNC:27055
Mus musculus	CDA	MGD	MGI:1919519
Felis catus	CDA	VGNC	VGNC:80163
Rattus norvegicus	CDA	RGD	RGD:1311101
Macaca mulatta	CDA	VGNC	VGNC:106338
Others	CDA	NCBI