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Cat. No.: HY-13599S1

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Cladribine-¹³C₅,¹⁵N₂

(Synonyms: 2-Chloro-2′-deoxyadenosine-¹³C₅,¹⁵N₂; CldAdo-¹³C₅,¹⁵N₂; 2CdA-¹³C₅,¹⁵N₂)

Cladribine-¹³C₅,¹⁵N₂ (2-Chloro-2′-deoxyadenosine-¹³C₅,¹⁵N₂) is ¹³C and ¹⁵N labeled Cladribine. Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis.

For research use only. We do not sell to patients.

Formula: C₅¹³C₅H₅ClN₃¹⁵N₂O₃
Molecular Weight:285.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Cladribine-¹³C₅,¹⁵N₂ Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Purity & Documentation
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Bioz

Biological Activity

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled Cas 4291-63-8
Molecular Weight 285.58
Formula C₅¹³C₅H₅ClN₃¹⁵N₂O₃
SMILES

O[13C][13C@@]1[13C@@](O)[13C][13C@]([15N]2C=[15N]C3=C2N=C(Cl)N=C3N)O1
Synonyms

2-Chloro-2′-deoxyadenosine-¹³C₅,¹⁵N₂; CldAdo-¹³C₅,¹⁵N₂; 2CdA-¹³C₅,¹⁵N₂
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Purity & Documentation
References

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Cladribine-13C5,15N2

Biological Activity

Chemical Information

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Cladribine-13C5,15N2 Related Classifications

HY-13599S1 Related Classifications

Cladribine-¹³C₅,¹⁵N₂

Cladribine-¹³C₅,¹⁵N₂ Related Classifications