2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt (Synonyms: ADU-S100 enantiomer ammonium salt; MIW815 enantiomer ammonium salt; ML RR-S2 CDA enantiomer ammonium salt)

Name: 2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt
Brand: MedChemExpress
SKU: HY-12885C
Rating: 4.5 (0 reviews)

Cat. No.: HY-12885C Purity: 98.94%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt (ADU-S100 enantiomer ammonium salt) is the less active enantiomer of 2’3’-c-di-AM(PS)2 (Rp,Rp). 2’3’-c-di-AM(PS)2 (Rp,Rp) is an activator of stimulator of interferon genes (STING).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt 화학구조

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of 2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt:

2’3’-c-di-AM(PS)2 (Rp,Rp) In-stock
2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt In-stock
2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt In-stock

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vitro

STING is a transmembrane protein localized to the endoplasmic reticulum that undergoes a conformational change in response to direct binding of cyclic dinucleotides, resulting in a downstream signaling cascade involving TBK1 activation, IRF-3 phosphorylation, and production of IFN-β and other cytokines. The direct activation of the STING pathway might be an effective therapeutic strategy to promote broad tumor-initiated T cell priming against tumor antigen repertoire^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

724.60

화학식

C₂₀H₃₀N₁₂O₁₀P₂S₂

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O[P@](OC[C@H]2O[C@@H](N3C(N=CN=C4N)=C4N=C3)[C@H](O)[C@@H]2O5)(S)=O)[C@H](N6C(N=CN=C7N)=C7N=C6)O[C@@H]1CO[P@]5(S)=O.N.N

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

용액&용해도

In Vitro:

H₂O : ≥ 100 mg/mL (138.01 mM)

DMSO : 50 mg/mL (69.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3801 mL	6.9004 mL	13.8007 mL
5 mM	0.2760 mL	1.3801 mL	2.7601 mL
10 mM	0.1380 mL	0.6900 mL	1.3801 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.45 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (3.45 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (3.45 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 98.94%

Select Batch:

Data Sheet (279 KB) SDS (394 KB)

COA (259 KB) HNMR (403 KB) RP-HPLC (268 KB) LCMS (99 KB)

Handling Instructions (2659 KB)

References

[1]. Corrales L, et al. Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity. Cell Rep. 2015 May 19;11(7):1018-30. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	1.3801 mL	6.9004 mL	13.8007 mL	34.5018 mL
	5 mM	0.2760 mL	1.3801 mL	2.7601 mL	6.9004 mL
	10 mM	0.1380 mL	0.6900 mL	1.3801 mL	3.4502 mL
	15 mM	0.0920 mL	0.4600 mL	0.9200 mL	2.3001 mL
	20 mM	0.0690 mL	0.3450 mL	0.6900 mL	1.7251 mL
	25 mM	0.0552 mL	0.2760 mL	0.5520 mL	1.3801 mL
	30 mM	0.0460 mL	0.2300 mL	0.4600 mL	1.1501 mL
	40 mM	0.0345 mL	0.1725 mL	0.3450 mL	0.8625 mL
	50 mM	0.0276 mL	0.1380 mL	0.2760 mL	0.6900 mL
	60 mM	0.0230 mL	0.1150 mL	0.2300 mL	0.5750 mL
H₂O	80 mM	0.0173 mL	0.0863 mL	0.1725 mL	0.4313 mL
H₂O	100 mM	0.0138 mL	0.0690 mL	0.1380 mL	0.3450 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomerADU-S100 enantiomerMIW815 enantiomerML RR-S2 CDA enantiomerIFNARInterferon-α/β receptorInterferon-alpha/beta receptorInhibitorinhibitorinhibit

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2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt (Synonyms: ADU-S100 enantiomer ammonium salt; MIW815 enantiomer ammonium salt; ML RR-S2 CDA enantiomer ammonium salt)

고객리뷰

Other Forms of 2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt:

2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

순도&문서

References

고객리뷰

2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report