ARRDC3 - arrestin domain containing 3 Gene

Also Known as TLIMP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57561

About ARRDC3

Cytogenetic location: 5q14.3 Genomic coordinates (GRCh38): 5:91,368,631-91,383,317 (from NCBI)

This gene has 7 transcripts (splice variants), 305 orthologues and 5 paralogues. Ubiquitous expression in bone marrow (RPKM 76.9), thyroid (RPKM 64.6) and 24 other tissues.

Summary

This gene encodes a member of the Arrestin family of proteins, which regulate G protein-mediated signaling. The encoded protein is thought to act as a regulator of breast Cancer growth and progression by binding to a phosphorylated form of Integrin beta4, a tumor-related antigen, targeting the Integrin for internalization and degradation. [provided by RefSeq, Jul 2016]

ARRDC3 Products (4)

mRNA Protein Name
NM_001329670.2 NP_001316599.1 arrestin domain-containing protein 3 isoform b
NM_001329671.2 NP_001316600.1 arrestin domain-containing protein 3 isoform b
NM_001329672.2 NP_001316601.1 arrestin domain-containing protein 3 isoform b
NM_020801.4 NP_065852.1 arrestin domain-containing protein 3 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-3 adrenergic receptor binding IDA
IDA: Inferred from direct assay
21982743 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20603614 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of hippo signaling IMP
IMP: Inferred from mutant phenotype
24114784 GOA
acts upstream of or within positive regulation of ubiquitin-protein transferase activity IPI
IPI: Inferred from physical interaction
23236378 GOA
Cellular Component GO Annotation Evidence References Source
located in endosome IDA
IDA: Inferred from direct assay
23236378 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
23236378 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARRDC3 Protein Structure

Arrestin_N

Arrestin_N: Arrestin (or S-antigen), N-terminal domain (19 - 165)

Arrestin_C

Arrestin_C: Arrestin (or S-antigen), C-terminal domain (188 - 313)

  • 0
  • 100
  • 200
  • 300
  • 414 a.a.
Protein Preferred Names Protein Names

arrestin domain-containing protein 3

  • TBP-2-like inducible membrane protein

ARRDC3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ARRDC3 Q96B67 HPGDS Homo sapiens O60760
Y2H Prey Pooling
32296183
Intra
ARRDC3 Q96B67 HPGDS Homo sapiens O60760
Y2H Array
25416956
Intra
ARRDC3 Q96B67 HPGDS Homo sapiens O60760
Y2H Array
32296183
Intra
ARRDC3 Q96B67 MORF4L1 Homo sapiens Q9UBU8-2
Validated Y2H
25416956
Intra
ARRDC3 Q96B67 WWOX Homo sapiens Q9NZC7-5
Y2H Prey Pooling
32296183
Intra
ARRDC3 Q96B67 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
Intra
ARRDC3 Q96B67 WWOX Homo sapiens Q9NZC7-5
Y2H Array
32296183
Intra
ARRDC3 Q96B67 EPN2 Homo sapiens O95208-2
Y2H Array
32296183
Intra
ARRDC3 Q96B67 EPN2 Homo sapiens O95208-2
Y2H Prey Pooling
32296183
Intra
ARRDC3 Q96B67 RABGEF1 Homo sapiens Q9UJ41-4
Validated Y2H
32296183
Intra
ARRDC3 Q96B67 RABGEF1 Homo sapiens Q9UJ41-4
Y2H Array
32296183
Intra
ARRDC3 Q96B67 RABGEF1 Homo sapiens Q9UJ41-4
Y2H Prey Pooling
32296183
Intra
ARRDC3 Q96B67 ITCH Homo sapiens Q96J02
Anti Tag CoIP
33961781
Intra
ARRDC3 Q96B67 ITCH Homo sapiens Q96J02
Anti Tag CoIP
28514442
Intra
ARRDC3 Q96B67 ITCH Homo sapiens Q96J02
Anti Tag CoIP
23236378
Intra
ARRDC3 Q96B67 ITCH Homo sapiens Q96J02
Anti Tag CoIP
38270169
Intra
ARRDC3 Q96B67 ITCH Homo sapiens Q96J02
Y2H
23236378
Intra
ARRDC3 Q96B67 UBE2E2 Homo sapiens Q96LR5
Validated Y2H
25416956
Intra
ARRDC3 Q96B67 UBE2E2 Homo sapiens Q96LR5
Validated Y2H
32296183
Intra
ARRDC3 Q96B67 UBE2E2 Homo sapiens Q96LR5
Y2H Array
25416956
Intra
ARRDC3 Q96B67 RAD18 Homo sapiens Q9NS91
Validated Y2H
32296183
Intra
ARRDC3 Q96B67 UBE2E3 Homo sapiens Q969T4
Y2H Array
32296183
Intra
ARRDC3 Q96B67 UBA52 Homo sapiens P62987
Y2H Array
32296183
Intra
ARRDC3 Q96B67 UBA52 Homo sapiens P62987
Y2H Prey Pooling
32296183
Intra
ARRDC3 Q96B67 SMARCD1 Homo sapiens Q96GM5
Validated Y2H
32296183
Intra
ARRDC3 Q96B67 STAM2 Homo sapiens O75886
Validated Y2H
25416956
Intra
ARRDC3 Q96B67 STAM2 Homo sapiens O75886
Y2H Prey Pooling
32296183
Intra
ARRDC3 Q96B67 STAM2 Homo sapiens O75886
Y2H Array
25416956
Intra
ARRDC3 Q96B67 STAM2 Homo sapiens O75886
Y2H Array
32296183
Intra
ARRDC3 Q96B67 MORF4L1 Homo sapiens Q9UBU8
Validated Y2H
25416956
Intra
ARRDC3 Q96B67 ADRB2 Homo sapiens P07550
Confocal
23236378
Intra
ARRDC3 Q96B67 ADRB2 Homo sapiens P07550
IF
23208550
Intra
ARRDC3 Q96B67 ADRB2 Homo sapiens P07550
Anti Tag CoIP
23236378
Intra
ARRDC3 Q96B67 TRIM42 Homo sapiens Q8IWZ5
Y2H Prey Pooling
25416956
Intra
ARRDC3 Q96B67 TRIM42 Homo sapiens Q8IWZ5
Validated Y2H
25416956
Intra
ARRDC3 Q96B67 TRIM42 Homo sapiens Q8IWZ5
Y2H Array
25416956
Intra
ARRDC3 Q96B67 TNFAIP3 Homo sapiens P21580
Y2H Prey Pooling
32296183
Intra
ARRDC3 Q96B67 TNFAIP3 Homo sapiens P21580
Y2H Array
32296183
Intra
ARRDC3 Q96B67 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
Intra
ARRDC3 Q96B67 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra
ARRDC3 Q96B67 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra
ARRDC3 Q96B67 NEDD4L Homo sapiens Q96PU5-2
Validated Y2H
32296183
Intra
ARRDC3 Q96B67 NEDD4L Homo sapiens Q96PU5
Anti Tag CoIP
38270169
Intra
ARRDC3 Q96B67 NEDD4L Homo sapiens Q96PU5
Anti Tag CoIP
33961781
Intra
ARRDC3 Q96B67 NEDD4L Homo sapiens Q96PU5
Y2H
23236378
Intra
ARRDC3 Q96B67 NEDD4L Homo sapiens Q96PU5
Anti Tag CoIP
23236378
Intra
ARRDC3 Q96B67 CCDC50 Homo sapiens Q8IVM0
Y2H Array
32296183
Intra
ARRDC3 Q96B67 CCDC50 Homo sapiens Q8IVM0
Y2H Prey Pooling
32296183
Intra
ARRDC3 Q96B67 NEDD4 Homo sapiens P46934
Anti Tag CoIP
33961781
Intra
ARRDC3 Q96B67 NEDD4 Homo sapiens P46934
Confocal
23236378
Intra
ARRDC3 Q96B67 NEDD4 Homo sapiens P46934
Anti Tag CoIP
38270169
Intra
ARRDC3 Q96B67 NEDD4 Homo sapiens P46934
Anti Tag CoIP
23208550
Intra
ARRDC3 Q96B67 DCUN1D1 Homo sapiens Q96GG9
Y2H Prey Pooling
25416956
Intra
ARRDC3 Q96B67 DCUN1D1 Homo sapiens Q96GG9
Validated Y2H
32296183
Intra
ARRDC3 Q96B67 DCUN1D1 Homo sapiens Q96GG9
Y2H Array
25416956
Intra
ARRDC3 Q96B67 WWP1 Homo sapiens Q9H0M0
Validated Y2H
32296183
Intra
ARRDC3 Q96B67 WWP1 Homo sapiens Q9H0M0
Y2H Prey Pooling
32296183
Intra
ARRDC3 Q96B67 WWP1 Homo sapiens Q9H0M0
Y2H Array
32296183
Intra
ARRDC3 Q96B67 WWP1 Homo sapiens Q9H0M0
Anti Tag CoIP
38270169
Intra
ARRDC3 Q96B67 WWP1 Homo sapiens Q9H0M0
Anti Tag CoIP
33961781
Intra
ARRDC3 Q96B67 WWP2 Homo sapiens O00308
Anti Tag CoIP
23236378
Intra
ARRDC3 Q96B67 WWP2 Homo sapiens O00308
Y2H Prey Pooling
32296183
Intra
ARRDC3 Q96B67 WWP2 Homo sapiens O00308
Y2H Array
32296183
Intra
ARRDC3 Q96B67 TOLLIP Homo sapiens Q9H0E2
Validated Y2H
32296183
Intra
ARRDC3 Q96B67 OTUB2 Homo sapiens Q96DC9
Y2H Prey Pooling
25416956
Intra
ARRDC3 Q96B67 OTUB2 Homo sapiens Q96DC9
Validated Y2H
32296183
Intra
ARRDC3 Q96B67 BAG3 Homo sapiens O95817
Y2H Array
25416956
Intra
ARRDC3 Q96B67 BAG3 Homo sapiens O95817
Y2H Prey Pooling
25416956
Intra
ARRDC3 Q96B67 OPTN Homo sapiens Q96CV9
Validated Y2H
32296183
Intra
ARRDC3 Q96B67 OPTN Homo sapiens Q96CV9
Y2H Prey Pooling
32296183
Intra
ARRDC3 Q96B67 OPTN Homo sapiens Q96CV9
Y2H Array
32296183
Intra
ARRDC3 Q96B67 UBAC1 Homo sapiens Q9BSL1
Validated Y2H
32296183
Intra
ARRDC3 Q96B67 UBAC1 Homo sapiens Q9BSL1
Y2H Array
32296183
Intra
ARRDC3 Q96B67 UBAC1 Homo sapiens Q9BSL1
Y2H Prey Pooling
32296183
Intra
ARRDC3 Q96B67 BCL6 Homo sapiens P41182
Y2H Array
32296183
Intra
ARRDC3 Q96B67 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
ARRDC3 Q96B67 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
ARRDC3 Q96B67 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
ARRDC3 Q96B67 ITGB4 Homo sapiens P16144
Anti Bait CoIP
20603614
Intra
ARRDC3 Q96B67 ITGB4 Homo sapiens P16144
Confocal
20603614
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01032 ARRDC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ARRDC3 VGNC VGNC:38140
Rattus norvegicus ARRDC3 RGD RGD:1359478
Bos taurus ARRDC3 VGNC VGNC:26173
Macaca mulatta ARRDC3 VGNC VGNC:69923
Mus musculus ARRDC3 MGD MGI:2145242
Felis catus ARRDC3 VGNC VGNC:59945
Others ARRDC3 NCBI