NEDD4 - NEDD4 E3 ubiquitin protein ligase Gene

Also Known as RPF1; NEDD4-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4734

About NEDD4

Cytogenetic location: 15q21.3 Genomic coordinates (GRCh38): 15:55,826,917-55,993,612 (from NCBI)

This gene has 13 transcripts (splice variants), 207 orthologues and 24 paralogues. Ubiquitous expression in placenta (RPKM 6.4), liver (RPKM 5.9) and 23 other tissues.

Summary

This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin Proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin Ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]

NEDD4 Products (6)

mRNA	Protein	Name
NM_001284338.2	NP_001271267.1	E3 ubiquitin-protein ligase NEDD4 isoform 3
NM_001284339.1	NP_001271268.1	E3 ubiquitin-protein ligase NEDD4 isoform 4
NM_001284340.1	NP_001271269.1	E3 ubiquitin-protein ligase NEDD4 isoform 5
NM_001329212.2	NP_001316141.1	E3 ubiquitin-protein ligase NEDD4 isoform 6
NM_006154.4	NP_006145.2	E3 ubiquitin-protein ligase NEDD4 isoform 1
NM_198400.3	NP_940682.2	E3 ubiquitin-protein ligase NEDD4 isoform 2

NEDD4 Protein Structure

HECT

0
300
600
900
1200
1319 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase NEDD4	HECT-type E3 ubiquitin transferase NEDD4

NEDD4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NEDD4	P46934	FGFR1	Homo sapiens	P11362	Pull Down	21765395
Intra	NEDD4	P46934	FGFR1	Homo sapiens	P11362	Peptide Array	21765395
Intra	NEDD4	P46934	FGFR1	Homo sapiens	P11362	FPS	21765395
Intra	NEDD4	P46934	MLANA	Homo sapiens	Q16655	Phage Display	37219487
Intra	NEDD4	P46934	SCNN1B	Homo sapiens	P51168	FPS	39009827
Intra	NEDD4	P46934	SCNN1B	Homo sapiens	P51168	Pull Down	21765395
Intra	NEDD4	P46934	SCNN1B	Homo sapiens	P51168	Peptide Array	21765395
Intra	NEDD4	P46934	SCNN1B	Homo sapiens	P51168	Far-WB	11359767
Intra	NEDD4	P46934	SCNN1B	Homo sapiens	P51168	Phage Display	39009827
Intra	NEDD4	P46934	SCNN1B	Homo sapiens	P51168	FPS	21765395
Intra	NEDD4	P46934	PIP4P2	Homo sapiens	Q8N4L2	Phage Display	37219487
Intra	NEDD4	P46934	UVRAG	Homo sapiens	Q9P2Y5	Phage Display	37219487
Intra	NEDD4	P46934	UVRAG	Homo sapiens	Q9P2Y5	Phage Display	35044719
Intra	NEDD4	P46934	MS4A10	Homo sapiens	Q96PG2	Phage Display	35044719
Intra	NEDD4	P46934	TRERF1	Homo sapiens	Q96PN7	Phage Display	37219487
Intra	NEDD4	P46934	TRERF1	Homo sapiens	Q96PN7	Phage Display	35044719
Intra	NEDD4	P46934	YWHAE	Homo sapiens	P62258	TAP	24981860
Intra	NEDD4	P46934	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	NEDD4	P46934	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	20562859
Intra	NEDD4	P46934	TP73	Homo sapiens	O15350	Phage Display	37219487
Intra	NEDD4	P46934	TP73	Homo sapiens	O15350	Phage Display	35044719
Intra	NEDD4	P46934	PRRG4	Homo sapiens	Q9BZD6	Phage Display	37219487
Intra	NEDD4	P46934	PRRG4	Homo sapiens	Q9BZD6	Phage Display	35044719
Intra	NEDD4	P46934	PRR7	Homo sapiens	Q8TB68	Anti Tag CoIP	33961781
Intra	NEDD4	P46934	PRR7	Homo sapiens	Q8TB68	Phage Display	35044719
Intra	NEDD4	P46934	RNF11	Homo sapiens	Q9Y3C5	Phage Display	35044719
Intra	NEDD4	P46934	RNF11	Homo sapiens	Q9Y3C5	FPS	37100772
Intra	NEDD4	P46934	UBB	Homo sapiens	P0CG47	TAP	24981860
Intra	NEDD4	P46934	PTEN	Homo sapiens	P60484	Pull Down	19345329
Intra	NEDD4	P46934	PTEN	Homo sapiens	P60484	Anti Bait CoIP	19345329
Intra	NEDD4	P46934	GABARAP	Homo sapiens	O95166	Pull Down	20562859
Intra	NEDD4	P46934	GABARAPL2	Homo sapiens	P60520	Pull Down	20562859
Intra	NEDD4	P46934	LITAF	Homo sapiens	Q99732	IF	16118794
Intra	NEDD4	P46934	LITAF	Homo sapiens	Q99732	Anti Bait CoIP	16118794
Intra	NEDD4	P46934	TMEM51	Homo sapiens	Q9NW97	Phage Display	37219487
Intra	NEDD4	P46934	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	20562859
Intra	NEDD4	P46934	SCNN1A	Homo sapiens	P37088	Far-WB	11359767
Intra	NEDD4	P46934	SCNN1A	Homo sapiens	P37088	Pull Down	11359767
Intra	NEDD4	P46934	SCNN1A	Homo sapiens	P37088	NMR	23665454
Intra	NEDD4	P46934	ENTREP1	Homo sapiens	Q15884	Phage Display	35044719
Intra	NEDD4	P46934	LDLRAD4	Homo sapiens	O15165	Phage Display	35044719
Cross	NEDD4	P46934	UL56	Human herpesvirus 2	P28282	FPS	37100772
Cross	NEDD4	P46934	VP40	Sudan ebolavirus	Q5XX06	FPS	37100772
Cross	NEDD4	P46934	VP40	Sudan ebolavirus	Q5XX06	Phage Display	37100772

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Liddle Syndrome 1	Liddle Syndrome Pseudoaldosteronism Liddle'S Syndrome LIDLS1 Lidls Pseudohyperaldosteronism Pseudoprimary Hyperaldosteronism Pseudohyperaldosteronism Type 1 Liddles Syndrome
Pseudohypoaldosteronism
Keloid Formation	KLDF
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Cowden Syndrome 1	Bannayan-Riley-Ruvalcaba Syndrome Pten Hamartoma Tumor Syndrome Lhermitte-Duclos Disease Bannayan-Zonana Syndrome Phts Riley-Smith Syndrome Bzs Ruvalcaba-Myhre-Smith Syndrome Multiple Hamartoma Syndrome Rmss Brrs Dysplastic Gangliocytoma Of The Cerebellum CWS1 Cs Cd Mham Pten Hamartoma Tumor Syndrome With Granular Cell Tumor Macrocephaly Multiple Lipomas And Hemangiomata Bannayan-Ruvalcaba-Riley Syndrome Myhre-Riley-Smith Syndrome LDD Cerebelloparenchymal Disorder Vi Hamartoma Syndrome, Multiple Bbrs Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata Macrocephaly, Multiple Lipomas, And Hemangiomata Macrocephaly Pseudopapilledema And Multiple Hemangiomas Ruvalcaba -Myhre-Smith Syndrome Ruvalcaba-Myhre Syndrome Cowden Disease Macrocephaly Pseudopapilledema And Multiple Hemangiomata Cerebellar Granule Cell Hypertrophy And Megalencephaly Cpd6 Pten Hamartoma Tumor Syndromes Cowden Syndrome, Type 1
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies
Spinocerebellar Ataxia 31	Spinocerebellar Ataxia Type 31 SCA31 Spinocerebellar Ataxia 16q22-Linked Spinocerebellar Ataxia, 16q22-Linked Pure Spinocerebellar Ataxia Japanese Type Sca4 Pure Japanese Type Ataxia, Spinocerebellar, Type 31
Charcot-Marie-Tooth Disease, Demyelinating, Type 1c	Charcot-Marie-Tooth Disease Type 1c CMT1C Hmsn1c Hmsn Ic Charcot-Marie-Tooth Disease, Type 1c Charcot-Marie-Tooth Neuropathy Type 1c Cmt, Slow Nerve Conduction Type C Charcot-Marie-Tooth Neuropathy, Type 1c Neuropathy, Hereditary Motor And Sensory, Type Ic Cmt Slow Nerve Conduction Type C Neuropathy Hereditary Motor And Sensory Type 1c Charcot-Marie-Tooth Disease 1c Charcot-Marie-Tooth Disease Demyelinating Type 1c Hereditary Motor And Sensory Neuropathy Ic Charcot-Marie-Tooth Disease, Type Ic
Ebola Hemorrhagic Fever	Ebola Virus Disease Viral Hemorrhagic Fever Hemorrhagic Fever, Ebola Ebola Ehf Ebola Fever Hemorrhagic Fevers, Viral Ebola Haemorrhagic Fever Ebod - [Ebola Disease] Evd - [Ebola Virus Disease] Ebola Virus Haemorrhagic Fever Vhf - [Viral Haemorrhagic Fever] Nos Viral Haemorrhagic Fever, Not Otherwise Specified
Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive	Charcot-Marie-Tooth Disease Type 4 Charcot-Marie-Tooth Disease Type 4e Hereditary Motor And Sensory Neuropathy Cmt4e CHN1 Hypomyelinating Neuropathy, Congenital, 1 Charcot-Marie-Tooth Neuropathy Type 4e Neuropathy, Congenital Hypomyelinating, 1 Ar-Cmt1 Autosomal Recessive Demyelinating Charcot-Marie-Tooth Cmt4 Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive Hypomyelination, Severe Congenital Charcot-Marie-Tooth Disease, Type 4e Charcot-Marie-Tooth Neuropathy, Type 4e Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy Autosomal Recessive Congenital Hypomyelinating Neuropathy Congenital Amyelinating Neuropathy Congenital Hypomyelinating Neuropathy Autosomal Recessive Neuropathy, Congenital Hypomyelinating Or Amyelinating Severe Congenital Hypomyelination Hereditary Sensory Motor Neuropathy Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive Neuropathy, Hypomyelinating, Congenital, Type 1 Neuropathy, Motor And Sensory, Hereditary Congenital Hypomyelinating Neuropathy Hereditary Motor And Sensory Neuropathies Hereditary Sensorimotor Neuropathy Hmsn - [Hereditary Motor And Sensory Neuropathy] Hsmn - [Hereditary Sensory And Motor Neuropathy] Hereditary Motor And Sensory Neuropathy, Types I-Iv
Cowden Syndrome	Cowden Disease Multiple Hamartoma Syndrome Cowden'S Disease Lhermitte-Duclos Disease Cd Cs Mham Dysplastic Gangliocytoma Of Cerebellum Cowden'S Syndrome Hamartoma Syndrome, Multiple
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Brugada Syndrome	Sudden Unexpected Nocturnal Death Syndrome Sudden Unexplained Nocturnal Death Syndrome Bangungut Brugada Type Idiopathic Ventricular Fibrillation Pokkuri Death Syndrome Sunds Idiopathic Ventricular Fibrillation, Brugada Type Sudden Unexplained Death Dream Disease Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome Sudden Unexplained Death Syndrome Suds Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110204	Heclin	Inhibitor	98.00%	Unkown
HY-134417	NSC2805	Inhibitor	99.42%	Unkown
HY-N10159	1-Benzyl-I3C	Inhibitor	99.68%	Unkown
HY-162809	XMU-MP-9		99.12%	Unkown
HY-110174	NAB2	Degrader	99.69%	Unkown
HY-153178	HECT E3-IN-1	Inhibitor	99.44%	Unkown
HY-179570	XMU-MP-10	Inhibitor	98.10%	Unkown
HY-122046	Amb123203		98.87%	Unkown
HY-RS09180	NEDD4L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09179	NEDD4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-124791	MMRi6		99.70%	Unkown
HY-175159	3-Phenyl-2H-azirine-2-carboxylic acid		/	Unkown
HY-RS17116	Nedd4l Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17232	Nedd4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23561	Nedd4l Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23685	Nedd4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NEDD4	VGNC	VGNC:59121
Rattus norvegicus	NEDD4	RGD	RGD:3157
Macaca mulatta	NEDD4	VGNC	VGNC:75302
Bos taurus	NEDD4	VGNC	VGNC:55128
Mus musculus	NEDD4	MGD	MGI:97297
Felis catus	NEDD4	VGNC	VGNC:80898
Others	NEDD4	NCBI