3-Phenyl-2H-azirine-2-carboxylic acid
3-Phenyl-2H-azirine-2-carboxylic acid is an E3 ubiquitin ligase ligand that can be used in studies related to PROTAC synthesis, such as ZSH-2117 (HY-174415).
For research use only. We do not sell to patients.
- CAS No.: 2223101-36-6
- Formula: C9H7NO2
- Molecular Weight:161.16
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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14173 |
NEDD4 |
In Vitro
3-Phenyl-2H-azirine-2-carboxylic acid serves as the E3 ubiquitin ligase ligand for ZSH-2117 (HY-174415), a covalent and selective EGFR PROTAC degrader with a DC50 of 45 nM. ZSH-2117 significantly inhibits cell proliferation and reduces the protein levels of AKT and ERK in the downstream EGFR signaling pathway. ZSH-2117 effectively suppresses tumor growth in Ba/F3-EGFRL858R/T790M/C797S xenograft mouse models[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2223101-36-6
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Molecular Weight 161.16
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Formula C9H7NO2
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SMILES
O=C(O)C1N=C1C2=CC=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
3-Phenyl-2H-azirine-2-carboxylic acid Related Classifications
HY-175159 Related Classifications
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