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Cat. No.: HY-174415

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ZSH-2117

ZSH-2117 is a covalent and selective EGFR PROTAC degrader with a DC₅₀ of 45 nM in Ba/F3-EGFR^{L858R/T790M/C797S} cells. ZSH-2117 significantly inhibits cell proliferation and reduces the downstream EGFR signaling proteins level of AKT and ERK. ZSH-2117 effectively inhibits tumor growth in Ba/F3-EGFR^{L858R/T790M/C797S} xenograft mice model.
(Pink: EGFR ligand (HY-175162); Blue: NEDD4 ligand (HY-175159); Black: linker).

For research use only. We do not sell to patients.

Formula: C₃₆H₃₉BrClN₈O₂P
Molecular Weight:762.08

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

ZSH-2117 Chemical Structure

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity

Description

ZSH-2117 is a covalent and selective EGFR PROTAC degrader with a DC₅₀ of 45 nM in Ba/F3-EGFR^{L858R/T790M/C797S} cells. ZSH-2117 significantly inhibits cell proliferation and reduces the downstream EGFR signaling proteins level of AKT and ERK. ZSH-2117 effectively inhibits tumor growth in Ba/F3-EGFR^{L858R/T790M/C797S} xenograft mice model^[1]. (Pink: EGFR ligand (HY-175162); Blue: NEDD4 ligand (HY-175159); Black: linker).

All PROTACs Isoforms :

All EGFR Isoforms :

All Akt Isoforms :

All ERK Isoforms :

Chemical Information

Molecular Weight 762.08
Formula C₃₆H₃₉BrClN₈O₂P
SMILES

O=C(N1CCN(C2CCN(C3=CC=C(NC4=NC=C(Cl)C(NC5=CC=CC=C5P(C)(C)=O)=N4)C=C3Br)CC2)CC1)C6N=C6C7=CC=CC=C7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. He X, et al. Covalent Recruitment of NEDD4 for Targeted Protein Degradation: Rational Design of Small Molecular Degraders. J Am Chem Soc. 2025 Jun 25;147(25):21512-21525. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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ZSH-2117

All PROTACs Isoforms

All EGFR Isoforms

All Akt Isoforms

All ERK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

ZSH-2117 Related Classifications

HY-174415 Related Classifications