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Cat. No.: HY-175162

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EGFR ligand-20

EGFR ligand-20 is a EGFR-binding ligand that serves as a target protein ligand for ZSH-2117 (HY-174415) and is used in studies related to PROTAC synthesis.

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화학식: C₁₂H₁₃ClN₃OP
분자량:281.68

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

EGFR ligand-20 Chemical Structure

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Amount: USD 0.00

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

EGFR ligand-20 is a EGFR-binding ligand that serves as a target protein ligand for ZSH-2117 (HY-174415) and is used in studies related to PROTAC synthesis^[1].

All EGFR Isoforms :

In Vitro

EGFR ligand-20 acts as a target protein ligand for ZSH-2117 (HY-174415), a covalent and selective EGFR PROTAC degrader with a DC₅₀ of 45 nM. ZSH-2117 effectively inhibits tumor growth in Ba/F3-EGFRL858R/T790M/C797S xenograft mouse models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 281.68
화학식 C₁₂H₁₃ClN₃OP
SMILES

O=P(C1=CC=CC=C1NC2=NC=NC=C2Cl)(C)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. He X, et al. Covalent Recruitment of NEDD4 for Targeted Protein Degradation: Rational Design of Small Molecular Degraders. Journal of the American Chemical Society. 2025 Jun 25;147(25):21512-21525. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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