ENTREP1 - endosomal transmembrane epsin interactor 1 Gene
Also Known as X123; ENTREP; C9orf61; FAM189A2
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 9413
Summary
Enables ubiquitin Ligase activator activity. Involved in CXCL12-activated CXCR4 signaling pathway and negative adaptation of signaling pathway. Located in endosome membrane and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Broad expression in thyroid (RPKM 15.5), lung (RPKM 12.0) and 14 other tissues.
ENTREP1 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NG_052888.1 [RefSeqGene] |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
28514442 | GOA |
| enables ubiquitin ligase activator activity |
IDA
IDA: Inferred from direct assay
|
34927784 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in CXCL12-activated CXCR4 signaling pathway |
IMP
IMP: Inferred from mutant phenotype
|
34927784 | GOA |
| involved in negative adaptation of signaling pathway |
IMP
IMP: Inferred from mutant phenotype
|
34927784 | GOA |
| acts upstream of receptor internalization |
IMP
IMP: Inferred from mutant phenotype
|
34927784 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in early endosome membrane |
IDA
IDA: Inferred from direct assay
|
34927784 | GOA |
| located in late endosome membrane |
IDA
IDA: Inferred from direct assay
|
34927784 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
34927784 | GOA |
| located in recycling endosome membrane |
IDA
IDA: Inferred from direct assay
|
34927784 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
Compound Screening Libraries
Virtual Screening
Customize Your Library
Drug Screening Service
ENTREP1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
ENTREP1 | Q15884 | ITCH | Homo sapiens | Q96J02 | 33961781 | |
|
Intra
|
ENTREP1 | Q15884 | ITCH | Homo sapiens | Q96J02 | 28514442 | |
|
Intra
|
ENTREP1 | Q15884 | PCNX3 | Homo sapiens | Q9H6A9 | 33961781 | |
|
Intra
|
ENTREP1 | Q15884 | YWHAZ | Homo sapiens | P63104 | 33961781 | |
|
Intra
|
ENTREP1 | Q15884 | YWHAZ | Homo sapiens | P63104 | 28514442 | |
|
Intra
|
ENTREP1 | Q15884 | ITCH | Homo sapiens | Q96J02-2 | 34927784 | |
|
Intra
|
ENTREP1 | Q15884 | ITCH | Homo sapiens | Q96J02-2 | 34927784 | |
|
Intra
|
ENTREP1 | Q15884 | HECW2 | Homo sapiens | Q9P2P5 | 33961781 | |
|
Intra
|
ENTREP1 | Q15884 | HECW2 | Homo sapiens | Q9P2P5 | 28514442 | |
|
Intra
|
ENTREP1 | Q15884 | NEDD4L | Homo sapiens | Q96PU5 | 33961781 | |
|
Intra
|
ENTREP1 | Q15884 | NEDD4 | Homo sapiens | P46934 | 33961781 | |
|
Intra
|
ENTREP1 | Q15884 | WWP1 | Homo sapiens | Q9H0M0 | 33961781 | |
|
Intra
|
ENTREP1 | Q15884 | WWP1 | Homo sapiens | Q9H0M0 | 29892012 | |
|
Intra
|
ENTREP1 | Q15884 | WWP2 | Homo sapiens | O00308 | 29892012 | |
|
Intra
|
ENTREP1 | Q15884 | WWP2 | Homo sapiens | O00308 | 31515488 | |
|
Intra
|
ENTREP1 | Q15884 | WWP2 | Homo sapiens | O00308 | 33961781 | |
|
Intra
|
ENTREP1 | Q15884 | WWP2 | Homo sapiens | O00308 | 28514442 | |
|
Intra
|
ENTREP1 | Q15884 | ANKRD13D | Homo sapiens | Q6ZTN6 | 28514442 | |
|
Intra
|
ENTREP1 | Q15884 | ANKRD13D | Homo sapiens | Q6ZTN6 | 33961781 |
Cross: Cross-species interaction
Intra: Intraspecies interaction