PIP4P2 - phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 Gene

Also Known as TMEM55A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55529

Summary

TMEM55A catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]
Ubiquitous expression in bone marrow (RPKM 11.6), adrenal (RPKM 9.7) and 24 other tissues.

PIP4P2 Products (1)

mRNA Protein Name
NM_018710.3 NP_061180.1 type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IDA
IDA: Inferred from direct assay
16365287 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in phosphatidylinositol dephosphorylation IDA
IDA: Inferred from direct assay
16365287 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in late endosome membrane IDA
IDA: Inferred from direct assay
16365287 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
16365287 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIP4P2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
PIP4P2 Q8N4L2 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
PIP4P2 Q8N4L2 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
PIP4P2 Q8N4L2 ZFYVE27 Homo sapiens Q5T4F4
Y2H Prey Pooling
32296183
Intra
PIP4P2 Q8N4L2 ZFYVE27 Homo sapiens Q5T4F4
Y2H Array
32296183
Intra
PIP4P2 Q8N4L2 NEDD4 Homo sapiens P46934
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-157714 08:0 PI(3,4)P2 / Unkown
HY-RS10565 PIP4P1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-157706 PI(3,4)P2 (18:1) ammonium salt Activator / Unkown
HY-172742 Dioctanoyl PI(3,4)P2 sodium / Unkown
HY-176832 PtdIns-(3,4)-P2 (1,2-dipalmitoyl) sodium / Unkown