2. Gene
  3. UVRAG - UV radiation resistance associated Gene

UVRAG - UV radiation resistance associated Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as p63; DHTX; VPS38

Gene ID: 7405 | Gene type: protein coding

About UVRAG

Cytogenetic location: 11q13.5 Genomic coordinates (GRCh38): 11:75,815,210-76,144,232 (from NCBI)

This gene has 9 transcripts (splice variants) and 214 orthologues. Ubiquitous expression in fat (RPKM 5.6), lymph node (RPKM 3.6) and 24 other tissues.

Summary

This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting Autophagy and suppressing the proliferation and tumorigenicity of human colon Cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon Cancer. [provided by RefSeq, Jul 2008]

UVRAG Products(5)

mRNA Protein Name
NM_001386671.1 NP_001373600.1 UV radiation resistance-associated gene protein isoform 1
NM_001386672.1 NP_001373601.1 UV radiation resistance-associated gene protein isoform 3
NM_001386673.1 NP_001373602.1 UV radiation resistance-associated gene protein isoform 4
NM_001386674.1 NP_001373603.1 UV radiation resistance-associated gene protein isoform 5
NM_003369.4 NP_003360.2 UV radiation resistance-associated gene protein isoform 2

UVRAG Protein Structure

C2

C2: C2 domain (46 - 95)

Atg14

Atg14: Vacuolar sorting 38 and autophagy-related subunit 14 (185 - 449)

  • 0
  • 200
  • 400
  • 600
  • 699 a.a.
Protein Preferred Names Protein Names

UV radiation resistance-associated gene protein

beclin 1 binding protein

Related Diseases

Diseases Alias
Cholecystolithiasis
Cornea Cancer

Malignant Neoplasm Of Cornea

Neoplasm Of Cornea

Corneal Tumor

Malignant Corneal Tumor

Malignant Tumor Of Cornea

Primary Malignant Neoplasm Of Cornea
Situs Inversus

Situs Inversus Viscerum

Laterality Sequence

Complete Transposition

Siv
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-156237 Beclin1-ATG14L interaction inhibitor 1 Inhibitor / Unkown
HY-152100 CUR5g Inhibitor 98.69% Unkown
HY-RS15588 UVRAG Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta UVRAG VGNC VGNC:78751
Felis catus UVRAG VGNC VGNC:66909
Rattus norvegicus UVRAG RGD RGD:1589754
Mus musculus UVRAG MGD MGI:1925860
Bos taurus UVRAG VGNC VGNC:36751
Canis familiaris UVRAG VGNC VGNC:48218