2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Apoptosis Reactive Oxygen Species (ROS)
  4. ZINC000002107582

ZINC000002107582 is a UVRAG binder. ZINC000002107582 induces Apoptosis, increases intracellular ROS levels, arrests the cell cycle at the S phase, and elevates the proportion of cells in the Sub G0 phase. ZINC000002107582 exhibits anticancer activity against breast cancer.

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ZINC000002107582

ZINC000002107582 Chemical Structure

CAS No. : 859138-65-1

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Description

ZINC000002107582 is a UVRAG binder. ZINC000002107582 induces Apoptosis, increases intracellular ROS levels, arrests the cell cycle at the S phase, and elevates the proportion of cells in the Sub G0 phase. ZINC000002107582 exhibits anticancer activity against breast cancer[1].

In Vitro

ZINC000002107582 (0.195-50 μM; 24 h) potently inhibits MCF-7 cell viability with an IC50 of 5 μM, showing a concentration-dependent cytotoxic effect over 24 h[1].
ZINC000002107582 (5-10 μM; 24 h) induces dose-dependent apoptosis in MCF-7 cells, with 53.91% early apoptotic cells at IC50 (5 μM) and 80.67% total apoptotic cells at 2×IC50 (10 μM) after 24 h[1].
ZINC000002107582 (5-10 μM; 24 h) induces dose-dependent intracellular ROS accumulation in MCF-7 cells, with 71.51% ROS-positive cells at IC50 (5 μM) and 83.97% ROS-positive cells at 2×IC50 (10 μM) after 24 h[1].
ZINC000002107582 (5-10 μM; 24 h) induces S-phase cell cycle arrest and increases the Sub-G0 apoptotic population in MCF-7 cells, with more pronounced effects at 2×IC50 (10 μM) than at IC50 (5 μM) after 24 h[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ZINC000002107582 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: human breast carcinoma MCF-7 cells
Concentration: 0.195-50 μM
Incubation Time: 24 h
Result: Caused a concentration-dependent reduction in cell viability.
Showed a slight reduction at 0.195-0.39 μM, a noticeable decrease at 0.781-3.125 μM, a pronounced reduction at 6.25-12.5 μM, and a significant decrease at 25-50 μM.
Reached a half-maximal inhibitory concentration (IC50) of 5 μM.

Apoptosis Analysis[1]

Cell Line: human breast carcinoma MCF-7 cells
Concentration: 5 μM (IC50); 10 μM (2×IC50)
Incubation Time: 24 h
Result: Resulted in 53.91% early apoptotic cells at IC50, while treatment at 2×IC50 resulted in 80.67% total apoptotic cells.
Showed a dose-dependent increase in apoptotic cell populations relative to untreated controls.

Cell Cycle Analysis[1]

Cell Line: human breast carcinoma MCF-7 cells
Concentration: 5 μM (IC50); 10 μM (2×IC50)
Incubation Time: 24 h
Result: Reduced the G0/G1 population to 38.13%, increased the S-phase fraction to 25%, increased the Sub-G0 population to 6.82%, and decreased the G2/M phase to 25.69% at IC50.
Increased the S-phase fraction to 34%, increased the Sub-G0 population to 12.09%, decreased the G2/M phase to ~10%, and kept the G0/G1 fraction reduced relative to untreated controls at 2×IC50.
Molecular Weight

513.58

Formula

C31H31NO6
CAS No.
SMILES

O=C(C1(C2=CC=CC=C2)CCN(C(CC3=C(C)C4=CC5=C(OC6=C5CCCC6)C(C)=C4OC3=O)=O)CC1)O
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ZINC000002107582 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZINC000002107582859138-65-1ZINC 000002107582ZINC-000002107582ApoptosisReactive Oxygen Species (ROS)MCF-7 cellsbreast cancer cellsUVRAG-BAX protein complexUVRAGcell cycleSub G0 populationBAXUVRAG C2 domainreactive oxygen speciesapoptotic cell deathInhibitorinhibitorinhibit

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