Beclin1-ATG14L interaction inhibitor 1
Based on 2 publication(s) in Google Scholar
Beclin1-ATG14L interaction inhibitor 1 (com 19) is a selective Beclin1-ATG14L interaction inhibitor. This protein interaction mechanism specifically targets complex I of the lipid kinase VPS34 without affecting complex II. Because the integrity of VPS34 complex II depends on the Beclin 1-UVRAG interaction. Beclin1-ATG14L interaction inhibitor 1 can disrupt the formation of VPS34 complex I and inhibit autophagy, but does not affect complex II-related vesicle transport.
For research use only. We do not sell to patients.
- Purity: 99.92%
- CAS No.: 1243063-73-1
- Formula: C23H24N4O5S
- Molecular Weight:468.53
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Beclin1-ATG14L interaction inhibitor 1
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Biological Activity
Chemical Information
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CAS No. 1243063-73-1
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Appearance Solid
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Molecular Weight 468.53
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Formula C23H24N4O5S
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Color White to off-white
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SMILES
O=C1N(CC2=NOC(C3CCC3)=N2)C4=CC(S(=O)(NC5=CC=CC(C)=C5C)=O)=CC=C4OC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Autophagy
RNF144A inhibits autophagy by targeting BECN1 for degradation during L. monocytogenes infection. [Abstract]2025 Apr;21(4):789-806. PMID: 39608349 -
Adv Sci (Weinh)
Coronavirus Nsp3 Hijacks CLTC to Modulate Autophagosome Nucleation for Promoting DMV Formation and Viral Replication. [Abstract]2026 Apr;13(24):e21626. PMID: 41721606
Solvent & Solubility
DMSO : 100 mg/mL (213.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.1343 mL | 10.6717 mL | 21.3434 mL | 53.3584 mL |
| 5 mM | 0.4269 mL | 2.1343 mL | 4.2687 mL | 10.6717 mL | |
| 10 mM | 0.2134 mL | 1.0672 mL | 2.1343 mL | 5.3358 mL | |
| 15 mM | 0.1423 mL | 0.7114 mL | 1.4229 mL | 3.5572 mL | |
| 20 mM | 0.1067 mL | 0.5336 mL | 1.0672 mL | 2.6679 mL | |
| 25 mM | 0.0854 mL | 0.4269 mL | 0.8537 mL | 2.1343 mL | |
| 30 mM | 0.0711 mL | 0.3557 mL | 0.7114 mL | 1.7786 mL | |
| 40 mM | 0.0534 mL | 0.2668 mL | 0.5336 mL | 1.3340 mL | |
| 50 mM | 0.0427 mL | 0.2134 mL | 0.4269 mL | 1.0672 mL | |
| 60 mM | 0.0356 mL | 0.1779 mL | 0.3557 mL | 0.8893 mL | |
| 80 mM | 0.0267 mL | 0.1334 mL | 0.2668 mL | 0.6670 mL | |
| 100 mM | 0.0213 mL | 0.1067 mL | 0.2134 mL | 0.5336 mL |
Beclin1-ATG14L interaction inhibitor 1 Related Classifications
HY-156237 Related Classifications
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