PIK3C3 - phosphatidylinositol 3-kinase catalytic subunit type 3 Gene

Also Known as VPS34; Vps34; hVps34

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5289

About PIK3C3

Cytogenetic location: 18q12.3 Genomic coordinates (GRCh38): 18:41,955,234-42,087,830 (from NCBI)

This gene has 16 transcripts (splice variants), 209 orthologues and 9 paralogues. Ubiquitous expression in testis (RPKM 7.2), brain (RPKM 7.0) and 25 other tissues.

Summary

Enables 1-phosphatidylinositol-3-kinase activity. Involved in early endosome to late endosome transport and regulation of cytokinesis. Acts upstream of or within Autophagy and protein lipidation. Located in autolysosome; late endosome; and midbody. [provided by Alliance of Genome Resources, Apr 2022]

PIK3C3 Products (5)

mRNA	Protein	Name
XM_047437549.1	XP_047293505.1	phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1
NM_002647.4	NP_002638.2	phosphatidylinositol 3-kinase catalytic subunit type 3 isoform 1
XM_047437550.1	XP_047293506.1	phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X2
XM_047437551.1	XP_047293507.1	phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X3
NM_001308020.2	NP_001294949.1	phosphatidylinositol 3-kinase catalytic subunit type 3 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 1-phosphatidylinositol-3-kinase activity	IDA IDA: Inferred from direct assay	7628435	GOA
enables 1-phosphatidylinositol-3-kinase activity	IMP IMP: Inferred from mutant phenotype	20208530	GOA
enables kinase activity	IDA IDA: Inferred from direct assay	25327288	GOA
enables phosphatidylinositol kinase activity	IDA IDA: Inferred from direct assay	7628435	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7504174	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in autophagosome assembly	IDA IDA: Inferred from direct assay	33637724	GOA
involved in autophagosome maturation	IDA IDA: Inferred from direct assay	10625637	GOA
acts upstream of or within autophagy	IMP IMP: Inferred from mutant phenotype	25327288	GOA
involved in early endosome to late endosome transport	IDA IDA: Inferred from direct assay	14617358	GOA
involved in early endosome to late endosome transport	IMP IMP: Inferred from mutant phenotype	14617358	GOA
involved in phosphatidylinositol phosphate biosynthetic process	IDA IDA: Inferred from direct assay	7628435	GOA
involved in phosphatidylinositol-3-phosphate biosynthetic process	IDA IDA: Inferred from direct assay	8999962	GOA
involved in positive regulation by host of viral genome replication	IDA IDA: Inferred from direct assay	34320401	GOA
acts upstream of or within protein lipidation	IMP IMP: Inferred from mutant phenotype	25327288	GOA
involved in regulation of autophagy	IDA IDA: Inferred from direct assay	16799551	GOA
involved in regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	20208530	GOA
involved in regulation of macroautophagy	IDA IDA: Inferred from direct assay	10625637	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in autolysosome	IDA IDA: Inferred from direct assay	25327288	GOA
located in late endosome	IDA IDA: Inferred from direct assay	14617358	GOA
located in midbody	IDA IDA: Inferred from direct assay	20208530	GOA
part of phosphatidylinositol 3-kinase complex, class III	IPI IPI: Inferred from physical interaction	25490155	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIK3C3 Protein Structure

PI3K_C2

PI3Ka

PI3_PI4_kinase

0
200
400
600
800
887 a.a.

Protein Preferred Names	Protein Names
phosphatidylinositol 3-kinase catalytic subunit type 3	PI3-kinase type 3 PI3K type 3 PtdIns-3-kinase type 3 phosphatidylinositol 3-kinase p100 subunit phosphoinositide-3-kinase, class 3 vacuolar protein sorting 34 homolog

PIK3C3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	PIK3C3	Q8NEB9	X	Hepatitis B virus	Q17UT5	Anti Bait CoIP	20142477
Cross	PIK3C3	Q8NEB9	X	Hepatitis B virus	Q17UT5	Anti Tag CoIP	20142477
Intra	PIK3C3	Q8NEB9	NRBF2	Homo sapiens	Q96F24	Anti Bait CoIP	24785657
Intra	PIK3C3	Q8NEB9	NRBF2	Homo sapiens	Q96F24	Anti Tag CoIP	20562859
Intra	PIK3C3	Q8NEB9	NRBF2	Homo sapiens	Q96F24	Anti Tag CoIP	24785657
Intra	PIK3C3	Q8NEB9	ATG14	Homo sapiens	Q6ZNE5	Anti Tag CoIP	19050071
Intra	PIK3C3	Q8NEB9	ATG14	Homo sapiens	Q6ZNE5	Anti Tag CoIP	20562859
Intra	PIK3C3	Q8NEB9	UVRAG	Homo sapiens	Q9P2Y5	Anti Tag CoIP	35271311
Intra	PIK3C3	Q8NEB9	UVRAG	Homo sapiens	Q9P2Y5	Anti Bait CoIP	24785657
Intra	PIK3C3	Q8NEB9	UVRAG	Homo sapiens	Q9P2Y5	Anti Tag CoIP	20562859
Intra	PIK3C3	Q8NEB9	UVRAG	Homo sapiens	Q9P2Y5	Anti Bait CoIP	24056303
Intra	PIK3C3	Q8NEB9	UVRAG	Homo sapiens	Q9P2Y5	Phosphotransferase	25490155
Intra	PIK3C3	Q8NEB9	UVRAG	Homo sapiens	Q9P2Y5	Anti Tag CoIP	24785657
Intra	PIK3C3	Q8NEB9	RUBCN	Homo sapiens	Q92622	Anti Tag CoIP	35271311
Intra	PIK3C3	Q8NEB9	RUBCN	Homo sapiens	Q92622	Anti Tag CoIP	20562859
Intra	PIK3C3	Q8NEB9	RUBCN	Homo sapiens	Q92622	Anti Bait CoIP	21062745

Cross: Cross-species interaction Intra: Intraspecies interaction

PIK3C3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83044	PI3 Kinase Class 3 Antibody (YA2789)	WB, IHC-P	Human, Mouse, Rat
HY-P86149	PI3 Kinase Class 3 Antibody (YA5841)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Neurodegeneration With Brain Iron Accumulation	Nbia Neurodegeneration With Brain Iron Accumulation Disorders Neurodegeneration, With Brain Iron Accumulation
Danon Disease	Pseudoglycogenosis Ii Antopol Disease Glycogen Storage Disease Iib Glycogen Storage Disease Type 2b Glycogen Storage Disease Type Iib Gsd2b Lysosomal Glycogen Storage Disease Without Acid Maltase Deficiency Vacuolar Cardiomyopathy And Myopathy X-Linked Vacuolar Cardiomyopathy And Myopathy, X-Linked Lysosomal Glycogen Storage Disease Without Acid Maltase Deficiency, Formerly Gsd2b, Formerly Gsd Iib, Formerly Glycogen Storage Cardiomyopathy Glycogen Storage Disease Limited To The Heart Pseudoglycogenosis 2 X-Linked Vacuolar Cardiomyopathy And Myopathy Lysosomal Glycogen Storage Disease With Normal Acid Maltase Glycogen Storage Disease Due To Lamp-2 Deficiency Gsd Due To Lamp-2 Deficiency Glycogenosis Due To Lamp-2 Deficiency Lysosomal Glycogen Storage Disease With Normal Acid Maltase Activity DAND Gsd-Iib
Myopathy, X-Linked, With Excessive Autophagy	X-Linked Myopathy With Excessive Autophagy Xmea MEAX Vacuolar Myopathy
Charcot-Marie-Tooth Disease, Axonal, Type 2e	Charcot-Marie-Tooth Disease Type 2 CMT2E CMT2S CMT2Y Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease Axonal Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2s Charcot-Marie-Tooth Disease, Type 2e Hereditary Motor And Sensory Neuropathy Type 2 Charcot-Marie-Tooth Neuropathy, Type 2s Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2y Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y Charcot-Marie-Tooth Neuropathy, Type 2y Charcot-Marie-Tooth Disease, Type 2y Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Neuropathy Type 2e Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation Cmt2 Due To Vcp Mutation Charcot-Marie-Tooth Disease Type 2s Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Cmt2 Charcot-Marie-Tooth Neuropathy, Type 2e Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type Hereditary Motor And Sensory Neuropathy Okinawa Type Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y Charcot-Marie-Tooth Neuropathy Type 2y Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s Charcot-Marie-Tooth Neuropathy Type 2s Charcot-Marie-Tooth Type 2 Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease 2e Charcot-Marie-Tooth Disease Axonal Type 2e Charcot-Marie-Tooth Disease Neuronal Type 2e Charcot-Marie-Tooth Disease 2s Charcot-Marie-Tooth Neuropathy Axonal Type 2s Charcot-Marie-Tooth Disease 2y Charcot-Marie-Tooth Disease, Type 2 Hereditary Motor And Sensory-Neuropathy Type Ii
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Centronuclear Myopathy	Myopathy, Centronuclear Myotubular Myopathy Cnm Myopathy, Myotubular Congenital Structural Myopathy
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Myopathy, Centronuclear, X-Linked	X-Linked Myotubular Myopathy Xlmtm X-Linked Centronuclear Myopathy Xlcnm CNMX Mtm1 Myotubular Myopathy, X-Linked Mtmx Myotubular Myopathy 1 Centronuclear Myopathy X-Linked Myotubular Myopathy Mtm Cnm Xmtm Myotubular Myopathy Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12481	SAR405	Inhibitor	99.74%	Unkown
HY-137506	XST-14		99.26%	Unkown
HY-12481A	SAR405 R enantiomer	Control	99.94%	Unkown
HY-RS10521	Pik3c3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-122888	MPT0L145		/	Unkown
HY-181062	VWK147		/	Unkown
HY-RS10520	PIK3C3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10522	Pik3c3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PIK3C3	VGNC	VGNC:44554
Bos taurus	PIK3C3	VGNC	VGNC:32888
Macaca mulatta	PIK3C3	VGNC	VGNC:75994
Mus musculus	PIK3C3	MGD	MGI:2445019
Rattus norvegicus	PIK3C3	RGD	RGD:620899
Felis catus	PIK3C3	VGNC	VGNC:68853
Others	PIK3C3	NCBI