1. PI3K/Akt/mTOR
  2. PI3K

SAR405 

Cat. No.: HY-12481 Purity: 98.48%
Data Sheet SDS Handling Instructions

SAR405 is highly potent and selective inhibitor of PIK3C3 with an IC50 of 27 nM.

For research use only. We do not sell to patients.
SAR405 Chemical Structure

SAR405 Chemical Structure

CAS No. : 1523406-39-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $151 In-stock
2 mg $100 In-stock
5 mg $155 In-stock
10 mg $260 In-stock
25 mg $560 In-stock
50 mg $1000 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Description

SAR405 is highly potent and selective inhibitor of PIK3C3 with an IC50 of 27 nM. SAR405 treatment inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition.Combining SAR405 with everolimus, the FDA-approved MTOR inhibitor, results in a significant synergy on the reduction of cell proliferation using renal tumor cells.

References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.2530 mL 11.2651 mL 22.5301 mL
5 mM 0.4506 mL 2.2530 mL 4.5060 mL
10 mM 0.2253 mL 1.1265 mL 2.2530 mL
References
M.Wt

443.85

Formula

C₁₉H₂₁ClF₃N₅O₂

CAS No.

1523406-39-4

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 27 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 98.48%

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Product Name:
SAR405
Cat. No.:
HY-12481
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