SH3GLB1 - SH3 domain containing GRB2 like, endophilin B1 Gene

Homo sapiens

Also known as Bif-1; CGI-61; PPP1R70; dJ612B15.2

Gene ID: 51100 | Gene type: protein coding

About SH3GLB1

Cytogenetic location: 1p22.3 Genomic coordinates (GRCh38): 1:86,704,576-86,748,184 (from NCBI)

This gene has 6 transcripts (splice variants), 275 orthologues and 12 paralogues. Ubiquitous expression in fat (RPKM 36.8), testis (RPKM 20.8) and 25 other tissues.

Summary

This gene encodes a Src homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 Family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

SH3GLB1 Products(5)

mRNA	Protein	Name
NM_001206651.2	NP_001193580.1	endophilin-B1 isoform 2
NM_001206652.2	NP_001193581.1	endophilin-B1 isoform 3
NM_001206653.2	NP_001193582.1	endophilin-B1 isoform 4
NM_001410824.1	NP_001397753.1	endophilin-B1 isoform 5
NM_016009.5	NP_057093.1	endophilin-B1 isoform 1

SH3GLB1 Protein Structure

BAR

SH3_9

0
100
200
300
365 a.a.

Protein Preferred Names

Protein Names

endophilin-B1

Bax-interacting factor 1

Related Diseases

Diseases

Alias

Noonan Syndrome 5

NS5	Noonan Syndrome, Type 5

Alveolar Echinococcosis

Echinococcus Multilocularis Infection	Echinococcosis
Alveolococcosis	Multilocular Hydatid
Small Fox Tapeworm

Taeniasis

Beef Tapeworm Infection	Infection By Taeniarhynchus Saginatus
Taenia Saginata Infectious Disease	Taenia Saginata Infection
Pork Tapeworm Infection	Armed Tapeworm Infection
Infection By Taenia Solium	Intestinal Taenia Solium Infection
Pork Tapeworm	Taenia Solium Taeniasis
Adult Pork Tapeworm Infection	Adult Pork Tapeworm
Beef Tapeworm	Infection By Taenia Saginata
Unarmed Tapeworm Infection	Taenia Saginata Taeniasis
Infection Due To Adult Tapeworm Taenia Saginata	Mediocanellata Taenia Infection
Infestation By Taenia Saginata	Infestation By Taenia Mediocanellata

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12839	SH3GLB1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SH3GLB1	VGNC	VGNC:77206
Bos taurus	SH3GLB1	VGNC	VGNC:34575
Rattus norvegicus	SH3GLB1	RGD	RGD:1304859
Canis familiaris	SH3GLB1	VGNC	VGNC:46127
Mus musculus	SH3GLB1	MGD	MGI:1859730
Felis catus	SH3GLB1	VGNC	VGNC:65109

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