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No matches for "

79177

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12

Inhibitors & Agonists

2

Isotope-Labeled Compounds

6

Antibodies

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-156498
    RMC-7977
    10+ Cited Publications

    		 Ras ERK Raf Ribosomal S6 Kinase (RSK) AMPK Apoptosis PARP Cancer
    RMC-7977 is an orally active triple-complex RAS inhibitor that can simultaneously bind to cyclophilin A (CYPA) (Kd = 195 nM) and KRAS (G12V) (Kd = 292 μM). It exhibits broad-spectrum inhibitory activity against KRAS, NRAS, and HRAS proteins and their various wild-type and mutant variants. RMC-7977 induces apoptosis by inhibiting the phosphorylation of ERK, CRAF, and RSK, as well as increasing PARP cleavage. This leads to tumor regression, reduces resistance in KRAS G12C cancer models, and demonstrates good tolerability across various RAS cancer models .
    RMC-7977
  • HY-15005
    Sofosbuvir
    Maximum Cited Publications
    117 Publications Verification

    GS-7977; PSI-7977

    		 HCV Infection Cancer
    Sofosbuvir (GS-7977) is an HCV RNA replication inhibitor with an EC50 of 92 nM .
    Sofosbuvir
  • HY-15005S1
    Sofosbuvir-d6
    1 Publications Verification

    PSI-7977-d6; GS-7977-d6

    		 Isotope-Labeled Compounds HCV Infection
    Sofosbuvir-d6 is the deuterium labeled Sofosbuvir. Sofosbuvir (PSI-7977) is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
    Sofosbuvir-d6
  • HY-162088
    DW71177

    		Epigenetic Reader Domain Inflammation/Immunology
    DW71177 is a novel [1,2,4]triazolo[4,3-a] quinoxaline-based potent and BD1-Selective BET inhibitor, and can be used for study of acute myeloid leukemia .
    DW71177
  • HY-15005R
    Sofosbuvir (Standard)

    GS-7977 (Standard); PSI-7977 (Standard)

    		 Reference Standards HCV Infection
    Sofosbuvir (Standard) is the analytical standard of Sofosbuvir. This product is intended for research and analytical applications. Sofosbuvir (GS-7977) is an HCV RNA replication inhibitor with an EC50 of 92 nM .
    Sofosbuvir (Standard)
  • HY-15005S
    Sofosbuvir-13C,d3

    PSI-7977-13C,d3; GS-7977-13C,d3

    		 Isotope-Labeled Compounds HCV Infection
    Sofosbuvir- 13C,d3 is the deuterium labeled Sofosbuvir. Sofosbuvir (PSI-7977) is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
    Sofosbuvir-13C,d3
  • HY-116164
    A-79175

    		Lipoxygenase Inflammation/Immunology
    A-79175 is a potent 5-lipoxygenase inhibitor that inhibits leukotriene formation. A-79175 is promising for research of various allergic and inflammatory diseases including asthma, allergic rhinitis, rheumatoid arthritis and inflammatory bowel disease .
    A-79175
  • HY-129685
    M79175

    		Aldose Reductase Metabolic Disease
    M79175 is an aldose reductase inhibitor that can be used in the study of early diabetic retinopathy .
    M79175
  • HY-R02441
    hsa-miR-7977 mimic

    		MicroRNA Cancer
    hsa-miR-7977 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    hsa-miR-7977 mimic
    hsa-miR-7977 mimic
  • HY-R02441A
    hsa-miR-7977 agomir

    		MicroRNA Cancer
    hsa-miR-7977 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-7977 agomir
    hsa-miR-7977 agomir
  • HY-RI02441A
    hsa-miR-7977 antagomir

    		MicroRNA Cancer
    hsa-miR-7977 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-7977 antagomir
    hsa-miR-7977 antagomir
  • HY-RI02441
    hsa-miR-7977 inhibitor

    		MicroRNA Cancer
    hsa-miR-7977 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    hsa-miR-7977 inhibitor
    hsa-miR-7977 inhibitor

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