CETN3 - centrin 3 Gene

Also Known as CEN3; CDC31

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1070

About CETN3

Cytogenetic location: 5q14.3 Genomic coordinates (GRCh38): 5:90,392,257-90,409,756 (from NCBI)

This gene has 6 transcripts (splice variants), 202 orthologues and 20 paralogues. Broad expression in testis (RPKM 62.8), adrenal (RPKM 10.5) and 21 other tissues.

Summary

The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and Other mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast counterpart. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

CETN3 Products (3)

mRNA	Protein	Name
NM_001297765.2	NP_001284694.1	centrin-3 isoform 1
NM_001297768.2	NP_001284697.1	centrin-3 isoform 3
NM_004365.4	NP_004356.2	centrin-3 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23591820	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centriole	IDA IDA: Inferred from direct assay	23591820	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
part of nuclear pore nuclear basket	IDA IDA: Inferred from direct assay	23591820	GOA
part of transcription export complex 2	IDA IDA: Inferred from direct assay	23591820	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CETN3 Protein Structure

EF-hand_7

0
100
167 a.a.

Protein Preferred Names	Protein Names
centrin-3	CDC31 yeast homolog

CETN3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CETN3	O15182	SGSM1	Homo sapiens	Q2NKQ1-4	Y2H Prey Pooling	32296183
Intra	CETN3	O15182	SGSM1	Homo sapiens	Q2NKQ1-4	Y2H Prey Pooling	25416956
Intra	CETN3	O15182	SGSM1	Homo sapiens	Q2NKQ1-4	Validated Y2H	32296183
Intra	CETN3	O15182	SGSM1	Homo sapiens	Q2NKQ1-4	Y2H Array	32296183
Intra	CETN3	O15182	SGK1	Homo sapiens	O00141	Y2H Prey Pooling	32296183
Intra	CETN3	O15182	SGK1	Homo sapiens	O00141	Y2H Array	32296183
Intra	CETN3	O15182	POC5	Homo sapiens	Q8NA72-3	SLC	27107012
Intra	CETN3	O15182	POC5	Homo sapiens	Q8NA72-3	Y2H Array	32296183
Intra	CETN3	O15182	POC5	Homo sapiens	Q8NA72-3	Y2H Prey Pooling	32296183
Intra	CETN3	O15182	POC5	Homo sapiens	Q8NA72-3	Y2H	27107012
Intra	CETN3	O15182	POC5	Homo sapiens	Q8NA72-3	Validated Y2H	32296183
Intra	CETN3	O15182	POC5	Homo sapiens	Q8NA72	Y2H Array	31515488
Intra	CETN3	O15182	POC5	Homo sapiens	Q8NA72	Anti Tag CoIP	35271311
Intra	CETN3	O15182	POC5	Homo sapiens	Q8NA72	Y2H Array	29892012
Intra	CETN3	O15182	LDB2	Homo sapiens	O43679	Validated Y2H	32296183
Intra	CETN3	O15182	LDB2	Homo sapiens	O43679	Y2H Array	32296183
Intra	CETN3	O15182	LDB2	Homo sapiens	O43679	Y2H Prey Pooling	32296183
Intra	CETN3	O15182	AGR2	Homo sapiens	O95994	Y2H Prey Pooling	32296183
Intra	CETN3	O15182	AGR2	Homo sapiens	O95994	Validated Y2H	32296183
Intra	CETN3	O15182	AGR2	Homo sapiens	O95994	Y2H Array	32296183
Intra	CETN3	O15182	CKMT2	Homo sapiens	P17540	Validated Y2H	32296183
Intra	CETN3	O15182	CKMT2	Homo sapiens	P17540	Y2H Array	32296183
Intra	CETN3	O15182	CKMT2	Homo sapiens	P17540	Y2H Prey Pooling	32296183
Intra	CETN3	O15182	TNNI1	Homo sapiens	P19237	Validated Y2H	32296183
Intra	CETN3	O15182	TNNI1	Homo sapiens	P19237	Y2H Array	32296183
Intra	CETN3	O15182	TNNI1	Homo sapiens	P19237	Y2H Prey Pooling	32296183
Intra	CETN3	O15182	RCN1	Homo sapiens	Q15293	Y2H Prey Pooling	32296183
Intra	CETN3	O15182	RCN1	Homo sapiens	Q15293	Validated Y2H	32296183
Intra	CETN3	O15182	RCN1	Homo sapiens	Q15293	Y2H Array	32296183
Intra	CETN3	O15182	TCAP	Homo sapiens	O15273	Anti Tag CoIP	33961781
Intra	CETN3	O15182	TCAP	Homo sapiens	O15273	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Retinitis Pigmentosa 28	RP28 Retinitis Pigmentosa, Type 28
Cranioectodermal Dysplasia 4	CED4 Sensenbrenner Syndrome 4 Dysplasia, Cranioectodermal, Type 4
Microcephalic Osteodysplastic Primordial Dwarfism, Type Ii	Microcephalic Osteodysplastic Primordial Dwarfism Type Ii Majewski Osteodysplastic Primordial Dwarfism Type Ii MOPD2 Mopd Ii Osteodysplastic Primordial Dwarfism Type Ii Mopdii Osteodysplastic Primordial Dwarfism Type 2 Osteodysplastic Primordial Dwarfism, Type Ii Pcnt-Related Microcephalic Osteodysplastic Primordial Dwarfism Microcephalic Osteodysplastic Primordial Dwarfism Type 2 Mopd 2 Microcephalic Osteodysplastic Primordial Dwarfism With Tooth Abnormalities Mopd Type Ii Microcephalic Osteodysplastic Primordial Dwarfism 2 Dwarfism, Primordial, Osteodysplastic, Microcephalic Type Ii
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02548	CETN3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CETN3	VGNC	VGNC:71016
Rattus norvegicus	CETN3	RGD	RGD:620249
Bos taurus	CETN3	VGNC	VGNC:27235
Felis catus	CETN3	VGNC	VGNC:60801
Mus musculus	CETN3	MGD	MGI:1097706
Canis familiaris	CETN3	VGNC	VGNC:39156
Others	CETN3	NCBI