LDB2 - LIM domain binding 2 Gene

Also Known as LDB1; CLIM1; LDB-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9079

About LDB2

Cytogenetic location: 4p15.32 Genomic coordinates (GRCh38): 4:16,501,541-16,898,645 (from NCBI)

This gene has 16 transcripts (splice variants), 209 orthologues and 1 paralogue. Broad expression in endometrium (RPKM 25.9), fat (RPKM 24.8) and 23 other tissues.

Summary

The protein encoded by this gene belongs to the LIM-domain binding family. Members of this family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. These proteins function as adapter molecules to allow assembly of transcriptional regulatory complexes. Genetic association studies suggest functions for this gene in rhegmatogenous retinal detachment and coronary artery disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

LDB2 Products (4)

mRNA Protein Name
NM_001130834.3 NP_001124306.1 LIM domain-binding protein 2 isoform b
NM_001290.5 NP_001281.1 LIM domain-binding protein 2 isoform a
NM_001304434.2 NP_001291363.1 LIM domain-binding protein 2 isoform c
NM_001304435.2 NP_001291364.1 LIM domain-binding protein 2 isoform d

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15231748 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
9853615 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LDB2 Protein Structure

LIM_bind

LIM_bind: LIM-domain binding protein (30 - 233)

  • 0
  • 100
  • 200
  • 300
  • 373 a.a.
Protein Preferred Names Protein Names

LIM domain-binding protein 2

  • LIM binding domain 2

LDB2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LDB2 O43679 GGACT Homo sapiens Q9BVM4
Validated Y2H
32296183
Intra
LDB2 O43679 LMO3 Homo sapiens Q8TAP4-4
Validated Y2H
32296183
Intra
LDB2 O43679 EGLN3 Homo sapiens Q9H6Z9
Validated Y2H
32296183
Intra
LDB2 O43679 LMO2 Homo sapiens P25791-3
Validated Y2H
32296183
Intra
LDB2 O43679 HDAC7 Homo sapiens Q8WUI4-6
Validated Y2H
32296183
Intra
LDB2 O43679 TSNAX Homo sapiens Q99598
Validated Y2H
32296183
Intra
LDB2 O43679 TSNAX Homo sapiens Q99598
Y2H
18330356
Intra
LDB2 O43679 LMO4 Homo sapiens P61968
Y2H
15231748
Intra
LDB2 O43679 LMO4 Homo sapiens P61968
Y2H
18330356
Intra
LDB2 O43679 LMO4 Homo sapiens P61968
Validated Y2H
32296183
Intra
LDB2 O43679 EXOC3L1 Homo sapiens Q86VI1
Validated Y2H
32296183
Intra
LDB2 O43679 SSBP3 Homo sapiens Q9BWW4
Y2H
18330356
Intra
LDB2 O43679 SSBP3 Homo sapiens Q9BWW4
Y2H Array
20211142
Intra
LDB2 O43679 SMARCD1 Homo sapiens Q96GM5
Validated Y2H
32296183
Intra
LDB2 O43679 PSMB1 Homo sapiens P20618
Validated Y2H
32296183
Intra
LDB2 O43679 EPM2AIP1 Homo sapiens Q7L775
Validated Y2H
32296183
Intra
LDB2 O43679 MYDGF Homo sapiens Q969H8
Validated Y2H
32296183
Intra
LDB2 O43679 C14orf119 Homo sapiens Q9NWQ9
Validated Y2H
32296183
Intra
LDB2 O43679 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
LDB2 O43679 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
LDB2 O43679 DGCR6L Homo sapiens Q9BY27
Validated Y2H
32296183
Intra
LDB2 O43679 LHX8 Homo sapiens Q68G74
Validated Y2H
32296183
Intra
LDB2 O43679 LMO1 Homo sapiens P25800
Validated Y2H
32296183
Intra
LDB2 O43679 TTC19 Homo sapiens Q6DKK2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Retinal Detachment

  • Retinal Detachments

  • Rhegmatogenous Retinal Detachment

  • Ruptured Retina With Detachment

  • Retinal Hole With Detachment
Acute Erythroid Leukemia

  • Acute Erythroleukemia

  • Di Guglielmo'S Syndrome

  • Aml M6

  • Acute Myeloid Leukemia Fab-M6

  • Acute Myeloid Leukemia M6

  • Erythroleukemia

  • Aml-M6

  • Acute Erythroleukemia M6a Subtype

  • Acute Erythroleukemia M6b Subtype

  • Di Guglielmo Syndrome

  • Acute Myeloid Leukemia, M6 Type

  • Acute Erythroblastic Leukemia

  • Acute Erythroleukemia - M6a Subtype

  • Acute Erythroleukemia - M6b Subtype

  • Acute Erythraemia And Erythroleukaemia

  • Acute Erythroid Leukaemia Without Mention Of Remission

  • Erythraemia

  • Erythraemic Myelosis

  • Erythroleukaemia

  • Acute Erythraemic Myelosis

  • Acute Erythraemia
Fetal Hemoglobin Quantitative Trait Locus 1

  • Hereditary Persistence Of Fetal Hemoglobin

  • Delta-Beta-Thalassemia

  • Delta-Beta Thalassemia

  • Delta Beta-Thalassemia

  • HBFQTL1

  • Hemoglobin F, Hereditary Persistence Of

  • Hpfh

  • Hereditary Persistence Of Fetal Hemoglobin, Hb Gene Cluster-Related

  • Hemoglobin, Fetal, Quantitative Trait Locus 1

  • Hereditary Persistence Of Fetal Hemoglobin Thalassemia

  • Hpfh - [Hereditary Persistence Of Fetal Haemoglobin]

  • Fetal Haemoglobin

  • Persistence Of Fetal Haemoglobin

  • Persistent Haemoglobin F
Hemoglobinopathy

  • Hemoglobinopathies
Sickle Cell Anemia

  • Hemoglobin Sc Disease

  • Anemia, Sickle Cell

  • Hbsc Disease

  • Sickle Cell-Hemoglobin C Disease Syndrome

  • Hb Ss Disease

  • Sickle Cell Trait

  • Drepanocytosis

  • Haemoglobin Sc Disease

  • Hb Sc Disease

  • Hb-S/Hb-C Disease

  • Hb-Ss Disease Without Crisis

  • Hemoglobin S Disease Without Crisis

  • Sickle Cell Anaemia

  • Sickle-Cell/Hb-C Disease Without Crisis

  • Sickle Cell - Hemoglobin C Disease

  • Hbs Disease

  • Hemoglobin S Disease

  • Sickling Disorder Due To Hemoglobin S

  • SKCA

  • Sickle Cell Disease

  • Sickle Cell-Hemoglobin C Disease

  • Sickle-Cell Disease Carrier

  • Sickle-Cell Heterozygous Disorder

  • Haemoglobin A-S Genotype

  • Hb-S - [Sickle Cell Haemoglobin] Carrier

  • Sickle Cell Haemoglobin Trait

  • As - [Sickle Cell Trait]

  • Hbas - [Sickle Cell Haemoglobin Trait]

  • Sickle-Cell Trait Haemoglobin Disease

  • Haemoglobin Sickle Cell Trait Disorder

  • Heterozygous Sickle Cell Trait

  • Hbas - [Heterozygous Haemoglobin S]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07569 LDB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LDB2 MGD MGI:894670
Bos taurus LDB2 VGNC VGNC:30822
Rattus norvegicus LDB2 RGD RGD:1307921
Macaca mulatta LDB2 VGNC VGNC:74246
Canis familiaris LDB2 VGNC VGNC:42619
Felis catus LDB2 VGNC VGNC:68028
Others LDB2 NCBI