SSBP3 - single stranded DNA binding protein 3 Gene

Also Known as CSDP; SSDP; SSDP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23648

About SSBP3

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:54,225,432-54,413,490 (from NCBI)

This gene has 16 transcripts (splice variants), 221 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 35.7), brain (RPKM 22.6) and 24 other tissues.

Summary

Predicted to enable single-stranded DNA binding activity and transcription coactivator activity. Predicted to be involved in head development and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SSBP3 Products (11)

mRNA	Protein	Name
NM_001009955.4	NP_001009955.1	single-stranded DNA-binding protein 3 isoform c
NM_001394360.1	NP_001381289.1	single-stranded DNA-binding protein 3 isoform d
NM_001394361.1	NP_001381290.1	single-stranded DNA-binding protein 3 isoofrm e
NM_001394362.1	NP_001381291.1	single-stranded DNA-binding protein 3 isosform f
NM_001394363.1	NP_001381292.1	single-stranded DNA-binding protein 3 isoform g
NM_001394364.1	NP_001381293.1	single-stranded DNA-binding protein 3 isoform h
NM_001394365.1	NP_001381294.1	single-stranded DNA-binding protein 3 isoform i
NM_001394366.1	NP_001381295.1	single-stranded DNA-binding protein 3 isoform i
NM_001394367.1	NP_001381296.1	single-stranded DNA-binding protein 3 isoform j
NM_018070.5	NP_060540.2	single-stranded DNA-binding protein 3 isoform b
NM_145716.4	NP_663768.1	single-stranded DNA-binding protein 3 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18330356	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SSBP3 Protein Structure

SSDP

0
100
200
300
388 a.a.

Protein Preferred Names	Protein Names
single-stranded DNA-binding protein 3	sequence-specific single-stranded-DNA-binding protein

SSBP3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SSBP3	Q9BWW4	TBC1D23	Homo sapiens	Q9NUY8-2	Y2H Prey Pooling	25416956
Intra	SSBP3	Q9BWW4	TBC1D23	Homo sapiens	Q9NUY8-2	Validated Y2H	25416956
Intra	SSBP3	Q9BWW4	NXT2	Homo sapiens	Q9NPJ8-3	Validated Y2H	32296183
Intra	SSBP3	Q9BWW4	TBC1D23	Homo sapiens	Q9NUY8	Y2H Array	25416956
Intra	SSBP3	Q9BWW4	LMX1B	Homo sapiens	O60663	Anti Tag CoIP	33961781
Intra	SSBP3	Q9BWW4	LMX1B	Homo sapiens	O60663	Pull Down	30833792
Intra	SSBP3	Q9BWW4	IL36RN	Homo sapiens	Q9UBH0	Validated Y2H	32296183
Intra	SSBP3	Q9BWW4	YES1	Homo sapiens	P07947	Y2H Array	25416956
Intra	SSBP3	Q9BWW4	LDB1	Homo sapiens	Q86U70	Y2H Array	25416956
Intra	SSBP3	Q9BWW4	LDB1	Homo sapiens	Q86U70	Anti Tag CoIP	33961781
Intra	SSBP3	Q9BWW4	LDB1	Homo sapiens	Q86U70	Pull Down	30833792
Intra	SSBP3	Q9BWW4	LDB1	Homo sapiens	Q86U70	Y2H Prey Pooling	25416956
Intra	SSBP3	Q9BWW4	LDB1	Homo sapiens	Q86U70	Validated Y2H	25416956
Intra	SSBP3	Q9BWW4	EWSR1	Homo sapiens	Q01844	Y2H Prey Pooling	25416956
Intra	SSBP3	Q9BWW4	NXT2	Homo sapiens	Q9NPJ8	Y2H Prey Pooling	25416956
Intra	SSBP3	Q9BWW4	NXT2	Homo sapiens	Q9NPJ8	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Panhypopituitarism, X-Linked	PHPX X-Linked Panhypopituitarism Pituitary Dwarfism Iv Panhypopituitarism X-Linked Pituitary Dwarfism Iv, Formerly Panhypopituitarism - X-Linked
Cockayne Syndrome	Cockayne'S Syndrome Dwarfism-Retinal Atrophy-Deafness Syndrome Neill-Dingwall Syndrome Progeria-Like Syndrome Progeroid Nanism Cs
Lissencephaly	Pachygyria Broad Gyri Of Cerebrum Large Gyri Of Cerebrum Macrogyria

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13807	SSBP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SSBP3	RGD	RGD:621502
Bos taurus	SSBP3	VGNC	VGNC:35308
Mus musculus	SSBP3	MGD	MGI:1919725
Canis familiaris	SSBP3	VGNC	VGNC:53451
Felis catus	SSBP3	VGNC	VGNC:107642
Macaca mulatta	SSBP3	VGNC	VGNC:77926
Others	SSBP3	NCBI