EWSR1 - EWS RNA binding protein 1 Gene

Also Known as EWS; EWS-FLI1; bK984G1.4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2130

About EWSR1

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:29,268,268-29,300,521 (from NCBI)

This gene has 22 transcripts (splice variants), 244 orthologues, 2 paralogues and is associated with 111 phenotypes. Ubiquitous expression in testis (RPKM 27.8), bone marrow (RPKM 27.6) and 25 other tissues.

Summary

This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various Other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009]

EWSR1 Products (5)

mRNA	Protein	Name
NM_001163285.2	NP_001156757.1	RNA-binding protein EWS isoform 3
NM_001163286.2	NP_001156758.1	RNA-binding protein EWS isoform 4
NM_001163287.2	NP_001156759.1	RNA-binding protein EWS isoform 5
NM_005243.4	NP_005234.1	RNA-binding protein EWS isoform 2
NM_013986.4	NP_053733.2	RNA-binding protein EWS isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	21988832	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EWSR1 Protein Structure

zf-RanBP

0
200
400
600
656 a.a.

Protein Preferred Names	Protein Names
RNA-binding protein EWS	Ewing sarcoma breakpoint region 1

EWSR1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EWSR1	Q01844	ATPAF2	Homo sapiens	Q8N5M1	Y2H Array	31515488
Intra	EWSR1	Q01844	ATPAF2	Homo sapiens	Q8N5M1	Y2H Prey Pooling	25416956
Intra	EWSR1	Q01844	SSBP3	Homo sapiens	Q9BWW4	Validated Y2H	25416956
Intra	EWSR1	Q01844	SSBP3	Homo sapiens	Q9BWW4	Y2H Array	25416956
Intra	EWSR1	Q01844	SMAD4	Homo sapiens	Q13485	Y2H Array	29892012
Intra	EWSR1	Q01844	SMAD4	Homo sapiens	Q13485	Y2H Pooling	16189514
Intra	EWSR1	Q01844	SMAD4	Homo sapiens	Q13485	Y2H Array	31515488
Intra	EWSR1	Q01844	TRAF2	Homo sapiens	Q12933	Y2H Array	25416956
Intra	EWSR1	Q01844	TFG	Homo sapiens	Q92734	Validated Y2H	25416956
Intra	EWSR1	Q01844	TFG	Homo sapiens	Q92734	Y2H Prey Pooling	25416956
Intra	EWSR1	Q01844	TRAF1	Homo sapiens	Q13077	Validated Y2H	25416956
Intra	EWSR1	Q01844	KAT5	Homo sapiens	Q92993	Pull Down	18509338
Intra	EWSR1	Q01844	KAT5	Homo sapiens	Q92993	Anti Tag CoIP	18509338
Intra	EWSR1	Q01844	FUS	Homo sapiens	P35637	Pull Down	23975937
Intra	EWSR1	Q01844	RASSF1	Homo sapiens	Q9NS23-2	Anti Tag CoIP	18347058
Intra	EWSR1	Q01844	RASSF1	Homo sapiens	Q9NS23-2	Y2H	18347058
Intra	EWSR1	Q01844	EP300	Homo sapiens	Q09472	Y2H	21988832
Intra	EWSR1	Q01844	PEF1	Homo sapiens	Q9UBV8	Validated Y2H	25416956
Intra	EWSR1	Q01844	PEF1	Homo sapiens	Q9UBV8	Y2H Prey Pooling	25416956
Intra	EWSR1	Q01844	PLSCR1	Homo sapiens	O15162	Validated Y2H	25416956
Intra	EWSR1	Q01844	PLSCR1	Homo sapiens	O15162	Y2H Prey Pooling	25416956
Intra	EWSR1	Q01844	MAPK1IP1L	Homo sapiens	Q8NDC0	Validated Y2H	25416956
Intra	EWSR1	Q01844	MAPK1IP1L	Homo sapiens	Q8NDC0	Y2H Pooling	16189514
Intra	EWSR1	Q01844	MAPK1IP1L	Homo sapiens	Q8NDC0	Y2H Array	25416956
Intra	EWSR1	Q01844	ATXN3	Homo sapiens	P54252	Y2H Array	16713569
Intra	EWSR1	Q01844	PLSCR1	Homo sapiens	O15162	Y2H Pooling	16189514
Intra	EWSR1	Q01844	PRR13	Homo sapiens	Q9NZ81	Y2H Array	25416956
Intra	EWSR1	Q01844	ZNF165	Homo sapiens	P49910	Pull Down	16189514
Intra	EWSR1	Q01844	ZNF165	Homo sapiens	P49910	Y2H Pooling	16189514
Intra	EWSR1	Q01844	SEC24D	Homo sapiens	O94855	Y2H Prey Pooling	25416956
Intra	EWSR1	Q01844	SEC24A	Homo sapiens	O95486	Y2H Prey Pooling	25416956
Intra	EWSR1	Q01844	SEC24A	Homo sapiens	O95486	Validated Y2H	25416956
Intra	EWSR1	Q01844	SEC24A	Homo sapiens	O95486	Y2H Array	25416956
Intra	EWSR1	Q01844	PRMT1	Homo sapiens	Q99873	Anti Tag CoIP	23455924

Cross: Cross-species interaction Intra: Intraspecies interaction

EWSR1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82525	EWSR1 Antibody (YA2270)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Desmoplastic Small Round Cell Tumor	Dsrct Desmoplastic Small Round-Cell Tumor Desmoplastic Small Round-Cell Neoplasm
Neurofibromatosis, Type I	Von Recklinghausen Disease Neurofibromatosis 1 Neurofibromatosis, Type 1 NF1 Neurofibromatosis, Peripheral Type Neurofibromatosis Type I Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion Familial Spinal Neurofibromatosis Fsnf Peripheral Neurofibromatosis Von Recklinghausen'S Neurofibromatosis Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion Neurofibromatosis Peripheral Type Von Recklinghausen Syndrome Neurofibromatosis Type 1 Von Recklinghausen Neuropathy Nf1 - [Neurofibromatosis Type 1] Recklinghausen Disease
Chondrosarcoma, Extraskeletal Myxoid	Extraskeletal Myxoid Chondrosarcoma Emc Myxoid Extraosseous Chondrosarcoma
Melanoma Of Soft Tissue	Clear Cell Sarcoma Of The Tendons And Aponeuroses
Neurofibromatosis-Noonan Syndrome	NFNS Neurofibromatosis Type 1 Neurofibromatosis With Noonan Phenotype Nf1 Von Recklinghausen Disease Neurofibromatosis Type 1-Noonan Syndrome Noonan Neurofibromatosis Syndrome Recklinghausen'S Disease Noonan-Neurofibromatosis Syndrome Fibromatosis Multiple Non Ossifying Disseminated Nonossifying Fibromas In Association With Cafe-Au-Lait Spots Jaffe Campanacci Syndrome Type 1 Neurofibromatosis Neurofibromatosis 1 Peripheral Neurofibromatosis Recklinghausen Disease, Nerve Jaffe-Campanacci Syndrome
Myxoid Chondrosarcoma
Clear Cell Sarcoma	Sarcoma, Clear Cell Adult Soft Part Clear Cell Sarcoma Clear Cell Sarcoma Of Soft Parts Malignant Melanoma Of Soft Parts Malignant Melanoma Of Soft Tissues Melanoma, Malignant, Of Soft Parts Sarcoma Clear Cell
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Chondrosarcoma	Cartilaginous Cancer Chondrosarcoma Of Bone Primary Chondrosarcoma Of The Bone CHDSA
Fibrous Histiocytoma	Benign Fibrous Histiocytoma Histiocytoma, Benign Fibrous Fibroxanthoma Histiocytoma Fibrous
Myxoid Liposarcoma	Myxoid/Round Cell Liposarcoma Liposarcoma, Myxoid Mrcls Myxoliposarcoma MXLIPO Liposarcoma Myxoid Liposarcoma
Extraosseous Ewing Sarcoma	Extraosseous Ewing'S Sarcoma Extraosseous Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Extraskeletal Ewing Sarcom Sarcoma Extraosseous Ewings Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Liposarcoma	Lipomatous Cancer
Askin'S Tumor	Askin Tumor Askin Tumour Askin'S Tumour
Rare Tumor	Rare Neoplasm
Ewing Sarcoma Of Bone	Ewing'S Sarcoma Of Bone Bone Ewing Sarcoma Bone Ewing'S Sarcoma Bone Localized Ewing Sarcoma Bone Localized Ewing'S Sarcoma Ewing'S Sarcoma/Bone Peripheral Primitive Neuroectodermal Tumor Localized Skeletal Ewing'S Sarcoma Localized Bone Ewing Sarcoma
Embryonal Rhabdomyosarcoma	Rhabdomyosarcoma, Embryonal Rhabdomyosarcoma Embryonal Botryoid Rhabdomyosarcoma Erms Spindle Cell Rhabdomyosarcomas
Extraosseous Chondrosarcoma	Extraskeletal Myxoid Chondrosarcoma
Thymus Clear Cell Carcinoma	Clear Cell Carcinoma Of The Thymus Thymic Clear Cell Carcinoma
Sarcomatosis
Myoepithelioma	Benign Myoepithelioma Myoepithelial Adenoma Myoepithelial Neoplasm Malignant Myoepithelioma
Myoepithelial Carcinoma	Malignant Myoepithelioma Myoepithelioma Carcinoma
Bone Epithelioid Hemangioma	Bone Hemangioma Hemangioma Of Bone Osseous Epithelioid Hemangioma Osseous Hemangioma
Sweat Gland Benign Neoplasm	Neoplasm Of Sweat Gland Sweat Gland Tumor Tumor Of The Sweat Gland Sweat Gland Neoplasms Sweat Gland Neoplasm
Myxoid Liposarcoma Of The Ovary	Myxoid Liposarcoma Of Ovary
Liposarcoma Of The Ovary	Liposarcoma Of Ovary
Small Cell Osteogenic Sarcoma	Small Cell Osteosarcoma Round Cell Osteosarcoma Osteosarcoma Small Cell
Parachordoma
Conventional Osteosarcoma	Intracortical Osteosarcoma Conventional Central Osteosarcoma Intracortical Osteogenic Sarcoma Medullary Osteosarcoma
Extraskeletal Mesenchymal Chondrosarcoma	Mesenchymal Extraosseous Chondrosarcoma
Rhabdomyosarcoma
Cellular Myxoid Liposarcoma	Round Cell Liposarcoma
Myxofibrosarcoma	Fibromyxosarcoma Fibromyxoid Sarcoma Myxoid Malignant Fibrous Histiocytoma Dermatofibrosarcoma Protuberans, Myxoid
Malignant Fibrous Histiocytoma	Undifferentiated Pleomorphic Sarcoma Ups Histiocytoma, Malignant Fibrous Fibroxanthosarcoma Mfh Malignant Fibrohistiocytic Tumors Histiocytoma, Fibrous, Malignant
Salivary Gland Carcinoma	Salivary Gland Cancer Malignant Neoplasm Of Salivary Gland Salivary Gland Neoplasms
Intracranial Primitive Neuroectodermal Tumor	Intracranial Pnet Intracranial Primitive Neuroectodermal Neoplasm
Skeletal Muscle Cancer	Malignant Tumor Of Skeletal Muscle Skeletal Muscle Neoplasm
Synovium Cancer	Malignant Tumor Of Synovium Synovial Neoplasm
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Localized Osteosarcoma	Localised Osteogenic Sarcoma Localised Osteosarcoma Localized Osteogenic Sarcoma
Muscle Cancer	Myosarcoma Malignant Neoplasm Of Muscle Malignant Tumor Of Muscle Malignant Tumor Of The Muscle Muscle Neoplasms Myomatous Neoplasm
Connective Tissue Benign Neoplasm	Soft Tissue Neoplasms Mesenchymal Tissue Neoplasm Neoplasm Of Soft Tissue Neoplasm Of Soft Tissues Soft Tissue Benign Neoplasm Tumor Of The Soft Tissue Soft Tissue Neoplasm
Mesenchymal Cell Neoplasm	Benign Miscellaneous Mesenchymal Tumor Mesenchymal Tumor Mesenchymal Tumors
Cauda Equina Neoplasm	Tumor Of The Cauda Equina Neoplasm Of Cauda Equina
Ectomesenchymoma	Rhabdomyosarcoma With Ganglionic Differentiation Malignant Ectomesenchymoma
Central Nervous System Mesenchymal Non-Meningothelial Tumor	Central Nervous System Mesenchymal Non-Meningothelial Tumour Non-Meningothelial Mesenchymal Tumor Non-Meningothelial Mesenchymal Tumour
Malignant Olfactory Nerve Neoplasm	Malignant Olfactory Nerve Tumor Malignant Tumor Of Olfactory Nerve Primary Malignant Neoplasm Of Olfactory Nerve
Well-Differentiated Liposarcoma	Atypical Lipomatous Tumor Atypical Lipoma Alt Wdls Liposarcoma, Well Differentiated Pleomorphic Lipoma
Monophasic Synovial Sarcoma	Monophasic Sarcoma Of Synovium
Elsahy-Waters Syndrome	Brachioskeletogenital Syndrome Bsg Syndrome Branchioskeletogenital Syndrome ESWS Hypospadias, Hypertelorism, Upper Lid Coloboma, And Mixed-Type Hearing Loss Branchio-Skeleto-Genital Syndrome
Epithelial-Myoepithelial Carcinoma	Clear Cell Adenoma Adenomyo-Epithelioma Clear Cell Carcinoma Emc Epithelial Myoepithelial Carcinoma Glycogen-Rich Adenocarcinoma Glycogen-Rich Adenoma Monomorphic Clear Cell Tumor Tubular Solid Adenoma Adenocarcinoma, Clear Cell
Small Intestinal Sarcoma	Sarcoma Of The Small Intestine
Epithelioid Malignant Peripheral Nerve Sheath Tumor	Epithelioid Mpnst Malignant Epithelioid Neoplasm Of The Peripheral Nerve Sheath
Pleomorphic Liposarcoma	Pls Liposarcoma Pleomorphic Liposarcoma, Pleomorphic
Congenital Fibrosarcoma	Infantile Fibrosarcoma
Childhood Fibrosarcoma	Pediatric Fibrosarcoma
Bone Osteosarcoma	Osteosarcoma Of Bone Primary Osteosarcoma Of Bone
Adrenal Neuroblastoma	Neuroblastoma Of Adrenal Gland Adrenal Gland Neuroblastoma Neuroblastoma Nos
Sweat Gland Disease	Sweat Gland Diseases
Ossifying Fibromyxoid Tumor	Ossifying Fibromyxoid Tumour Ossifying Fibromyxoma
Kidney Rhabdoid Cancer	Rhabdoid Tumor Of The Kidney Kidney Rhabdoid Tumor Renal Rhabdoid Tumor
Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor	Extraosseous Ewing'S Tumor Extraosseous Ewing'S Tumour Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumour
Spindle Cell Rhabdomyosarcoma
Cranial Nerve Malignant Neoplasm	Cranial Nerve Neoplasms Malignant Neoplasm Of Cranial Nerve Malignant Tumor Of Cranial Nerve Malignant Tumor Of The Cranial Nerve
Biphasic Synovial Sarcoma	Synovial Sarcoma, Biphasic Biphasic Sarcoma Of Synovium
Lung Sarcoma	Pulmonary Sarcoma
Kidney Fibrosarcoma	Fibrosarcoma Of The Kidney
Alveolar Soft Part Sarcoma	ASPS Alveolar Soft-Part Sarcoma Sarcoma, Alveolar Soft Part Alveolar Soft Tissue Sarcoma Sarcoma Alveolar Soft Part Adult Alveolar Soft-Part Sarcoma Childhood Alveolar Soft-Part Sarcoma
Bladder Leiomyoma	Leiomyoma Of The Urinary Bladder
Mesenchymal Chondrosarcoma	Chondrosarcoma, Mesenchymal Chondrosarcoma Mesenchymal
Soft Tissue Chondroma	Extraskeletal Chondroma
Essential Tremor	Benign Essential Tremor Familial Tremor Hereditary Essential Tremor Essential Hereditary Tremor Shaky Hand Syndrome Benign Essential Tremor Syndrome Tremor Hereditary Essential Essential Tremor, Susceptibility To Tremor, Hereditary Essential
Astroblastoma, Mn1-Altered	Cns High-Grade Neuroepithelial Tumors With Mn1 Alteration
Bone Sarcoma
Bone Cancer	Malignant Bone Neoplasm Bone Carcinoma Bone Neoplasms Bone Neoplasm Bone Tumour Ca - Bone Cancer Malignant Bone Tumour Malignant Neoplasm Of Bone Malignant Osseous Tumor Neoplasm Of Bone Osseous Tumor Osteosarcoma Of Bone Osteogenic Neoplasm
Dedifferentiated Liposarcoma	Ddls Liposarcoma Dedifferentiated Liposarcoma, Dedifferentiated
Fibrosarcoma	Neoplasms, Fibrous Tissue Fibrocytic Tumor Fibrosarcoma Of Soft Tissue Fibrous Tissue Neoplasm
Thymus Sarcomatoid Carcinoma	Thymic Carcinosarcoma Thymic Sarcomatoid Carcinoma
Vulvar Sarcoma	Sarcoma Of Vulva Vulva Sarcoma
Hidradenoma	Adenoma, Sweat Gland Hidradenoma Of Skin Sweat Gland Adenoma Syringoadenoma Eccrine Acrospiroma Benign Neoplasm Of Sweat Gland
Olfactory Neuroblastoma	Esthesioneuroblastoma Asthesioneuroblastoma Esthesioneuroepithelioma Olfactory Esthesioneuroblastoma Paranasal Sinus Olfactory Neuroblastoma Esthesioneuroblastoma, Olfactory Esthesioneuroblastoma Of Nasal Cavity
Breast Rhabdomyosarcoma	Rhabdomyosarcoma Of The Breast
Pleomorphic Lipoma	Lipoma Lipoma Pleomorphic Lipomatosis, Multiple
Kidney Sarcoma	Renal Sarcoma Sarcoma Of Kidney
Chordoid Meningioma	Meningioma, Chordoid
Hemangioma	Hemangiomas
Clear Cell Chondrosarcoma	Chondrosarcoma, Clear Cell
Sarcoma, Synovial	Synovial Sarcoma Synovialosarcoma Synovial Cell Sarcoma Sarcoma Synovial
Epithelioid Sarcoma	Epithelioid Cell Sarcoma Sarcoma Epithelioid Sarcoma, Epithelioid
Dermatofibrosarcoma Protuberans	DFSP Dermatofibrosarcoma Giant Cell Fibroblastoma Metastatic Dermatofibrosarcoma Protuberans Familial Dermatofibrosarcoma Protuberans Darier-Ferrand Tumor Darier-Hoffmann Tumor
Central Nervous System Primitive Neuroectodermal Neoplasm	Cpnet
Pericytoma With T(7;12)
Spindle Cell Sarcoma	Sarcoma Sarcoma Spindle Cell Sarcoma, Spindle Cell Sarcoma - Category
Rhabdoid Cancer	Rhabdoid Tumor Malignant Rhabdoid Tumor Malignant Rhabdoid Tumour Rhabdoid Sarcoma Rhabdoid Tumor Predisposition Syndrome 1 Rhabdoid Tumor Predisposition Syndrome 2 Atypical Teratoid Rhabdoid Tumor Brain Tumor, Posterior Fossa, Of Infancy, Familial Atypical Teratoid/Rhabdoid Tumor
Astroblastoma	Cerebral Astroblastoma
Atypical Teratoid Rhabdoid Tumor	Rhabdoid Tumor Predisposition Syndrome Rtps Atypical Teratoid/Rhabdoid Tumor Rhabdoid Predisposition Syndrome Familial Posterior Fossa Brain Tumor Of Infancy Familial Rhabdoid Tumor At/Rt Atypical Teratoid Rhabdoid Tumour Atypical Teratoid/Rhabdoid Tumour Rhabdoid Tumor Of The Cns Rhabdoid Tumour Of The Cns Familial Posterior Fossa Brain Tumor Syndrome Hereditary Swi/Snf Deficiency Syndrome Atrt
Perivascular Tumor	Malignant Perivascular Cancer
Parosteal Osteosarcoma	Juxtacortical Osteosarcoma Parosteal Osteogenic Sarcoma Osteosarcoma, Juxtacortical
Kidney Cortex Disease
Rhabdomyosarcoma 2	Alveolar Rhabdomyosarcoma Rhabdomyosarcoma, Alveolar Rhabdomyosarcoma Alveolar RMS2 Rmsa Rhabdomyosarcoma 2, Alveolar Alveolar Childhood Rhabdomyosarcoma Arms Rhabdomyosarcoma, Type 2
Constipation
Multisystem Proteinopathy
Kidney Clear Cell Sarcoma	Clear Cell Sarcoma Of Kidney Childhood Kidney Clear Cell Sarcoma Renal Clear Cell Sarcoma Ccsk Clear Cell Sarcoma Of The Kidney
Bone Benign Neoplasm
Inflammatory Myofibroblastic Tumor	Inflammatory Fibrosarcoma
Skin Benign Neoplasm	Neoplasm Of Skin By Site Tumor Of The Skin Skin Tumor Benign Neoplasm Of Skin Skin Neoplasms
Lipomatosis, Multiple	Lipoma Familial Multiple Lipomatosis Lipomatosis, Familial Multiple Benign Lipomatous Tumor Lipomatous Neoplasm Multiple Lipomatosis Fml Lipo Benign Tumor Of Adipose Tissue Lipomatous Tumor Tumor Of Adipose Tissue Neoplasms, Adipose Tissue Lipomas
Pseudosarcomatous Fibromatosis	Nodular Fasciitis Pseudosarcomatous Fasciitis Fasciitis - Nodular Fasciitis Nodular
Vascular Cancer	Blood Vessel Tumors Malignant Vascular Neoplasm Renal Vein Leiomyosarcoma Vascular Neoplasms Blood Vessel Neoplasm Blood Vessel Tumor Blood Vessel Tumour Disorder Haemangiomatous Tumour Leiomyosarcoma Of The Renal Vein Malignant Great Vessel Tumor Malignant Tumor Of Pulmonary Artery Malignant Tumor Of Pulmonary Vein Malignant Vascular Tumor Neoplasm Of Great Vessel Pulmonary Artery Malignant Neoplasm Pulmonary Vein Malignant Neoplasm Vascular Tissue Neoplasm Vascular Tumors Blood Vessel Cancer Neoplasms, Vascular Tissue Malignant Neoplasm Of Great Vessels
Salivary Gland Disease	Salivary Gland Disorders Salivary Gland Diseases Non-Neoplastic Salivary Gland Disease Non-Neoplastic Salivary Gland Disorder Disorder Of Salivary Gland Lesion Of Salivary Gland Nos
Tibial Adamantinoma	Tibial Adamantinoma Morphology
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Tonsil Cancer	Tonsillar Neoplasms Malignant Neoplasm Of Faucial Tonsil Malignant Neoplasm Of Palatine Tonsil Malignant Neoplasm Of Tonsil, Faucial Malignant Tonsillar Tumor Malignant Tumor Of Tonsil Tonsillar Carcinoma Malignant Neoplasm Tonsil
Peripheral Nervous System Neoplasm	Peripheral Nervous System Neoplasms Nerve Sheath Neoplasm Neoplasm Of Peripheral Nerve Tumor Of Pns Nerve Sheath Neoplasms Nerve Sheath Tumors
Endometrial Stromal Sarcoma	Ess Endometrial Stromal Sarcoma, High Grade Undifferentiated Endometrial Sarcoma Stromal Sarcoma Of The Corpus Uteri Sarcoma Endometrial Stromal Sarcoma, Endometrial Stromal Undifferentiated Stromal Sarcoma
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Epithelioid Cell Synovial Sarcoma	Synovial Sarcoma, Epithelioid Cell Epithelioid Synovial Sarcoma
Autonomic Nervous System Neoplasm	Tumor Of Autonomic Nervous System
Endobronchial Lipoma
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Orbit Rhabdomyosarcoma	Rhabdomyosarcoma Of The Orbit Rhabdomyosarcoma Of Orbit
Invasive Malignant Thymoma	Infiltrating Thymoma Thymoma Malignant Invasive Invasive Thymoma And Thymic Carcinoma
Gallbladder Melanoma	Malignant Melanoma Of Gallbladder
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1	FTDALS1 Frontotemporal Dementia And/Or Motor Neuron Disease Ftdmnd Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia Alsftd Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1 Frontotemporal Dementia With Motor Neuron Disease Ftdals Ftd-Als Ftd-Mnd Frontotemporal Dementia With Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1 Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1 Frontotemporal Lobar Degeneration Grn-Related Frontotemporal Dementia
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-173364	EB-TCIP	Inducer	99.58%	Unkown
HY-154979	Anti-hepatic fibrosis agent 2		/	Unkown
HY-RS04581	EWSR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19681	Ewsr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26174	Ewsr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EWSR1	MGD	MGI:99960
Bos taurus	EWSR1	VGNC	VGNC:28638
Macaca mulatta	EWSR1	VGNC	VGNC:72446
Felis catus	EWSR1	VGNC	VGNC:61994
Rattus norvegicus	EWSR1	RGD	RGD:1307258
Canis familiaris	EWSR1	VGNC	VGNC:57411
Others	EWSR1	NCBI