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PEF1 - penta-EF-hand domain containing 1 Gene

Also Known as ABP32; PEF1A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 553115

About PEF1

Cytogenetic location: 1p35.2 Genomic coordinates (GRCh38): 1:31,629,866-31,644,876 (from NCBI)

This gene has 8 transcripts (splice variants), 214 orthologues and 20 paralogues. Ubiquitous expression in thyroid (RPKM 29.9), placenta (RPKM 14.6) and 25 other tissues.

Summary

This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. The encoded protein has been shown to form a heterodimer with the programmed cell death 6 gene product and may modulate its function in CA(2+) signaling. Alternative splicing results in multiple transcript variants and a pseudogene has been identified on chromosome 1.[provided by RefSeq, May 2010]

PEF1 Products (2)

mRNA	Protein	Name
NM_001359651.2	NP_001346580.1	peflin isoform 2
NM_012392.4	NP_036524.1	peflin isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	27716508	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein dimerization activity	IPI IPI: Inferred from physical interaction	11883899	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	11278427	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IMP IMP: Inferred from mutant phenotype	27716508	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in COPII vesicle coating	IMP IMP: Inferred from mutant phenotype	27716508	GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	27716508	GOA
involved in neural crest cell development	IMP IMP: Inferred from mutant phenotype	27716508	GOA
involved in neural crest formation	IMP IMP: Inferred from mutant phenotype	27716508	GOA
involved in positive regulation of protein monoubiquitination	IMP IMP: Inferred from mutant phenotype	27716508	GOA
involved in response to calcium ion	IPI IPI: Inferred from physical interaction	11278427	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of COPII vesicle coat	IDA IDA: Inferred from direct assay	27716508	GOA
part of Cul3-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	27716508	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11278427	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PEF1 Protein Structure

EF-hand_7

0
100
200
284 a.a.

Protein Preferred Names	Protein Names
peflin	PEF protein with a long N-terminal hydrophobic domain

PEF1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PEF1	Q9UBV8	METTL15	Homo sapiens	A6NJ78-4	Y2H Prey Pooling	32296183
Intra	PEF1	Q9UBV8	METTL15	Homo sapiens	A6NJ78-4	Y2H Array	32296183
Intra	PEF1	Q9UBV8	KRTAP12-1	Homo sapiens	P59990	Y2H Prey Pooling	32296183
Intra	PEF1	Q9UBV8	KRTAP12-1	Homo sapiens	P59990	Y2H Array	32296183
Intra	PEF1	Q9UBV8	HEMK1	Homo sapiens	Q9Y5R4	Validated Y2H	32296183
Intra	PEF1	Q9UBV8	CTAG1A	Homo sapiens	P78358	Y2H Prey Pooling	32296183
Intra	PEF1	Q9UBV8	CTAG1A	Homo sapiens	P78358	Y2H Array	32296183
Intra	PEF1	Q9UBV8	FAM168A	Homo sapiens	Q92567-2	Y2H Prey Pooling	32296183
Intra	PEF1	Q9UBV8	FAM168A	Homo sapiens	Q92567-2	Y2H Array	32296183
Intra	PEF1	Q9UBV8	KRTAP15-1	Homo sapiens	Q3LI76	Y2H Prey Pooling	32296183
Intra	PEF1	Q9UBV8	KRTAP15-1	Homo sapiens	Q3LI76	Y2H Array	32296183
Intra	PEF1	Q9UBV8	EIF4G1	Homo sapiens	Q04637-9	Y2H Prey Pooling	32296183
Intra	PEF1	Q9UBV8	EIF4G1	Homo sapiens	Q04637-9	Y2H Array	32296183
Intra	PEF1	Q9UBV8	ANKRD10	Homo sapiens	Q9NXR5-2	Y2H Array	32296183
Intra	PEF1	Q9UBV8	ANKRD10	Homo sapiens	Q9NXR5-2	Y2H Prey Pooling	32296183
Intra	PEF1	Q9UBV8	SMUG1	Homo sapiens	Q53HV7-2	Y2H Prey Pooling	32296183
Intra	PEF1	Q9UBV8	SMUG1	Homo sapiens	Q53HV7-2	Y2H Array	32296183
Intra	PEF1	Q9UBV8	SOHLH1	Homo sapiens	Q5JUK2	Y2H Prey Pooling	32296183
Intra	PEF1	Q9UBV8	SOHLH1	Homo sapiens	Q5JUK2	Y2H Array	32296183
Intra	PEF1	Q9UBV8	KRTAP19-1	Homo sapiens	Q8IUB9	Y2H Prey Pooling	32296183
Intra	PEF1	Q9UBV8	KRTAP19-1	Homo sapiens	Q8IUB9	Y2H Array	32296183
Intra	PEF1	Q9UBV8	STH	Homo sapiens	Q8IWL8	Y2H Prey Pooling	32296183
Intra	PEF1	Q9UBV8	STH	Homo sapiens	Q8IWL8	Y2H Array	32296183
Intra	PEF1	Q9UBV8	BAG4	Homo sapiens	O95429	Y2H Array	32296183
Intra	PEF1	Q9UBV8	BAG4	Homo sapiens	O95429	Y2H Prey Pooling	32296183
Intra	PEF1	Q9UBV8	PDCD6	Homo sapiens	O75340	Validated Y2H	25416956
Intra	PEF1	Q9UBV8	PDCD6	Homo sapiens	O75340	Y2H Prey Pooling	32296183
Intra	PEF1	Q9UBV8	PDCD6	Homo sapiens	O75340	Y2H Array	32296183
Intra	PEF1	Q9UBV8	PDCD6	Homo sapiens	O75340	Anti Tag CoIP	33961781
Intra	PEF1	Q9UBV8	PDCD6	Homo sapiens	O75340	Y2H Prey Pooling	25416956
Intra	PEF1	Q9UBV8	TFG	Homo sapiens	Q92734	Validated Y2H	25416956
Intra	PEF1	Q9UBV8	TFG	Homo sapiens	Q92734	Y2H Array	25416956
Intra	PEF1	Q9UBV8	TFG	Homo sapiens	Q92734	Y2H Prey Pooling	25416956
Intra	PEF1	Q9UBV8	AKAP8L	Homo sapiens	Q9ULX6	Y2H Prey Pooling	32296183
Intra	PEF1	Q9UBV8	AKAP8L	Homo sapiens	Q9ULX6	Validated Y2H	32296183
Intra	PEF1	Q9UBV8	AKAP8L	Homo sapiens	Q9ULX6	Y2H Array	32296183
Intra	PEF1	Q9UBV8	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	PEF1	Q9UBV8	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	PEF1	Q9UBV8	CFAP68	Homo sapiens	Q9H5F2	Y2H Array	32296183
Intra	PEF1	Q9UBV8	CFAP68	Homo sapiens	Q9H5F2	Y2H Prey Pooling	32296183
Intra	PEF1	Q9UBV8	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	PEF1	Q9UBV8	DAZAP2	Homo sapiens	Q15038	Y2H Pooling	19060904
Intra	PEF1	Q9UBV8	DAZAP2	Homo sapiens	Q15038	Y2H Array	19060904
Intra	PEF1	Q9UBV8	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	PEF1	Q9UBV8	KLHL12	Homo sapiens	Q53G59	Y2H Pooling	16189514
Intra	PEF1	Q9UBV8	KLHL12	Homo sapiens	Q53G59	Y2H Array	25416956
Intra	PEF1	Q9UBV8	KLHL12	Homo sapiens	Q53G59	Y2H Prey Pooling	32296183
Intra	PEF1	Q9UBV8	KLHL12	Homo sapiens	Q53G59	Pull Down	16189514
Intra	PEF1	Q9UBV8	KLHL12	Homo sapiens	Q53G59	Y2H Array	32296183
Intra	PEF1	Q9UBV8	CALCOCO2	Homo sapiens	Q13137	Y2H Array	25416956
Intra	PEF1	Q9UBV8	EWSR1	Homo sapiens	Q01844	Y2H Array	25416956
Intra	PEF1	Q9UBV8	HGS	Homo sapiens	O14964	Y2H Prey Pooling	25416956
Intra	PEF1	Q9UBV8	HGS	Homo sapiens	O14964	Validated Y2H	25416956
Intra	PEF1	Q9UBV8	SPG21	Homo sapiens	Q9NZD8	Y2H Prey Pooling	32296183
Intra	PEF1	Q9UBV8	SPG21	Homo sapiens	Q9NZD8	Y2H Array	32296183
Intra	PEF1	Q9UBV8	CEP55	Homo sapiens	Q53EZ4	Y2H Array	25416956
Intra	PEF1	Q9UBV8	CEP55	Homo sapiens	Q53EZ4	Y2H Prey Pooling	32296183
Intra	PEF1	Q9UBV8	CEP55	Homo sapiens	Q53EZ4	Y2H Array	32296183
Intra	PEF1	Q9UBV8	CEP55	Homo sapiens	Q53EZ4	Y2H Prey Pooling	25416956
Intra	PEF1	Q9UBV8	CEP55	Homo sapiens	Q53EZ4	Validated Y2H	25416956
Intra	PEF1	Q9UBV8	FOXR2	Homo sapiens	Q6PJQ5	Y2H Array	32296183
Intra	PEF1	Q9UBV8	FOXR2	Homo sapiens	Q6PJQ5	Y2H Array	31515488
Intra	PEF1	Q9UBV8	FOXR2	Homo sapiens	Q6PJQ5	Y2H Prey Pooling	32296183
Intra	PEF1	Q9UBV8	BPIFA1	Homo sapiens	Q9NP55	Y2H Prey Pooling	32296183
Intra	PEF1	Q9UBV8	BPIFA1	Homo sapiens	Q9NP55	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

PEF1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81827	PEF1 Antibody (YA1572)	WB, FC	Human, Mouse, Rat
HY-P81827A	PEF1 Antibody (YA1572)(PBS only)	WB, FC	Human, Mouse, Rat

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10317	PEF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PEF1	VGNC	VGNC:64110
Mus musculus	PEF1	MGD	MGI:1915148
Rattus norvegicus	PEF1	RGD	RGD:1359536
Bos taurus	PEF1	VGNC	VGNC:32739
Canis familiaris	PEF1	VGNC	VGNC:44412
Others	PEF1	NCBI