2. Gene
  3. BAG4 - BAG cochaperone 4 Gene

BAG4 - BAG cochaperone 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as SODD; BAG-4

Gene ID: 9530 | Gene type: protein coding

About BAG4

Cytogenetic location: 8p11.23 Genomic coordinates (GRCh38): 8:38,176,855-38,213,301 (from NCBI)

This gene has 4 transcripts (splice variants), 192 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 11.2), bone marrow (RPKM 7.7) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell Apoptosis and growth related proteins including Bcl-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/HSP70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo Apoptosis while Integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

BAG4 Products(2)

mRNA Protein Name
NM_001204878.2 NP_001191807.1 BAG family molecular chaperone regulator 4 isoform 2
NM_004874.4 NP_004865.1 BAG family molecular chaperone regulator 4 isoform 1

BAG4 Protein Structure

BAG

BAG: BAG domain (382 - 455)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 457 a.a.
Protein Preferred Names Protein Names

BAG family molecular chaperone regulator 4

BCL2 associated athanogene 4

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01345 BAG4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus BAG4 VGNC VGNC:26408
Canis familiaris BAG4 VGNC VGNC:38366
Macaca mulatta BAG4 VGNC VGNC:70220
Mus musculus BAG4 MGD MGI:1914634
Felis catus BAG4 VGNC VGNC:78455
Rattus norvegicus BAG4 RGD RGD:1560875
Others BAG4 NCBI