KCTD6 - potassium channel tetramerization domain containing 6 Gene
Also Known as KCASH3
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 200845
Summary
Enables ankyrin binding activity; cullin family protein binding activity; and identical protein binding activity. Involved in negative regulation of smoothened signaling pathway and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in brain (RPKM 6.8), endometrium (RPKM 3.6) and 25 other tissues.
KCTD6 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001128214.2 | NP_001121686.1 | BTB/POZ domain-containing protein KCTD6 |
| NM_153331.3 | NP_699162.3 | BTB/POZ domain-containing protein KCTD6 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables ankyrin binding |
IDA
IDA: Inferred from direct assay
|
22573887 | GOA |
| enables cullin family protein binding |
IDA
IDA: Inferred from direct assay
|
21472142 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
21472142 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
21145461 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in negative regulation of smoothened signaling pathway |
IDA
IDA: Inferred from direct assay
|
21472142 | GOA |
| involved in ubiquitin-dependent protein catabolic process |
IDA
IDA: Inferred from direct assay
|
21472142 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
KCTD6 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
KCTD6 | Q8NC69 | b2r8y4_human | Homo sapiens | B2R8Y4 | 25416956 | |
|
Intra
|
KCTD6 | Q8NC69 | b2r8y4_human | Homo sapiens | B2R8Y4 | 25416956 | |
|
Intra
|
KCTD6 | Q8NC69 | GOLGA8DP | Homo sapiens | Q0D2H9 | 25416956 | |
|
Intra
|
KCTD6 | Q8NC69 | REL | Homo sapiens | Q04864-2 | 32296183 | |
|
Intra
|
KCTD6 | Q8NC69 | REL | Homo sapiens | Q04864-2 | 32296183 | |
|
Intra
|
KCTD6 | Q8NC69 | TEPSIN | Homo sapiens | Q96N21 | 32296183 | |
|
Intra
|
KCTD6 | Q8NC69 | TEPSIN | Homo sapiens | Q96N21 | 32296183 | |
|
Intra
|
KCTD6 | Q8NC69 | TEPSIN | Homo sapiens | Q96N21 | 32296183 | |
|
Intra
|
KCTD6 | Q8NC69 | TBC1D2 | Homo sapiens | Q9BYX2-5 | 32296183 | |
|
Intra
|
KCTD6 | Q8NC69 | PRPF31 | Homo sapiens | Q8WWY3 | 32296183 | |
|
Intra
|
KCTD6 | Q8NC69 | PRPF31 | Homo sapiens | Q8WWY3 | 25416956 | |
|
Intra
|
KCTD6 | Q8NC69 | PRPF31 | Homo sapiens | Q8WWY3 | 25416956 | |
|
Intra
|
KCTD6 | Q8NC69 | EHHADH | Homo sapiens | Q08426 | 31515488 | |
|
Intra
|
KCTD6 | Q8NC69 | EHHADH | Homo sapiens | Q08426 | 25416956 | |
|
Intra
|
KCTD6 | Q8NC69 | EHHADH | Homo sapiens | Q08426 | 33961781 | |
|
Intra
|
KCTD6 | Q8NC69 | EHHADH | Homo sapiens | Q08426 | 25416956 | |
|
Intra
|
KCTD6 | Q8NC69 | CUL3 | Homo sapiens | Q13618 | 32296183 | |
|
Intra
|
KCTD6 | Q8NC69 | KCTD6 | Homo sapiens | Q8NC69 | 21472142 | |
|
Intra
|
KCTD6 | Q8NC69 | KCTD6 | Homo sapiens | Q8NC69 | 25416956 | |
|
Intra
|
KCTD6 | Q8NC69 | CUL3 | Homo sapiens | Q13618 | 25416956 | |
|
Intra
|
KCTD6 | Q8NC69 | CUL3 | Homo sapiens | Q13618 | 33961781 | |
|
Intra
|
KCTD6 | Q8NC69 | CUL3 | Homo sapiens | Q13618 | 27152988 | |
|
Intra
|
KCTD6 | Q8NC69 | CUL3 | Homo sapiens | Q13618 | 32296183 | |
|
Intra
|
KCTD6 | Q8NC69 | GSDMD | Homo sapiens | P57764 | 25416956 | |
|
Intra
|
KCTD6 | Q8NC69 | GSDMD | Homo sapiens | P57764 | 31515488 | |
|
Intra
|
KCTD6 | Q8NC69 | BAG4 | Homo sapiens | O95429 | 32296183 | |
|
Intra
|
KCTD6 | Q8NC69 | BAG4 | Homo sapiens | O95429 | 32296183 | |
|
Intra
|
KCTD6 | Q8NC69 | ACTN1 | Homo sapiens | P12814 | 25416956 | |
|
Intra
|
KCTD6 | Q8NC69 | ACTN1 | Homo sapiens | P12814 | 25416956 | |
|
Intra
|
KCTD6 | Q8NC69 | PSMA1 | Homo sapiens | P25786 | 32296183 | |
|
Intra
|
KCTD6 | Q8NC69 | PSMA1 | Homo sapiens | P25786 | 32296183 | |
|
Intra
|
KCTD6 | Q8NC69 | PPIG | Homo sapiens | Q13427 | 25416956 | |
|
Intra
|
KCTD6 | Q8NC69 | PPIG | Homo sapiens | Q13427 | 25416956 | |
|
Intra
|
KCTD6 | Q8NC69 | PPIG | Homo sapiens | Q13427 | 25416956 | |
|
Intra
|
KCTD6 | Q8NC69 | CDC23 | Homo sapiens | Q9UJX2 | 32296183 | |
|
Intra
|
KCTD6 | Q8NC69 | CDC23 | Homo sapiens | Q9UJX2 | 25416956 | |
|
Intra
|
KCTD6 | Q8NC69 | CDC23 | Homo sapiens | Q9UJX2 | 25416956 | |
|
Intra
|
KCTD6 | Q8NC69 | ZCCHC10 | Homo sapiens | Q8TBK6 | 25416956 | |
|
Intra
|
KCTD6 | Q8NC69 | CTNND1 | Homo sapiens | O60716-29 | 25416956 | |
|
Intra
|
KCTD6 | Q8NC69 | CTNND1 | Homo sapiens | O60716-29 | 25416956 | |
|
Intra
|
KCTD6 | Q8NC69 | C8orf33 | Homo sapiens | Q9H7E9 | 25416956 | |
|
Intra
|
KCTD6 | Q8NC69 | SDCBP | Homo sapiens | O00560 | 25416956 | |
|
Intra
|
KCTD6 | Q8NC69 | SDCBP | Homo sapiens | O00560 | 25416956 | |
|
Intra
|
KCTD6 | Q8NC69 | SDCBP | Homo sapiens | O00560 | 25416956 | |
|
Intra
|
KCTD6 | Q8NC69 | LNX1 | Homo sapiens | Q8TBB1 | 25416956 | |
|
Intra
|
KCTD6 | Q8NC69 | LNX1 | Homo sapiens | Q8TBB1 | 29892012 | |
|
Intra
|
KCTD6 | Q8NC69 | NTAQ1 | Homo sapiens | Q96HA8 | 32296183 | |
|
Intra
|
KCTD6 | Q8NC69 | PICK1 | Homo sapiens | Q9NRD5 | 32296183 | |
|
Intra
|
KCTD6 | Q8NC69 | GRB7 | Homo sapiens | Q14451 | 25416956 |
Cross: Cross-species interaction
Intra: Intraspecies interaction
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Bioactive Molecules
(21)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS07186 | KCTD1 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS07187 | KCTD10 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS07188 | KCTD11 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS07189 | KCTD12 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS07190 | KCTD13 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS07191 | KCTD14 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS07192 | KCTD15 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS07193 | KCTD16 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS07194 | KCTD17 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS07195 | KCTD3 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS07196 | KCTD4 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS07197 | KCTD5 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS07198 | KCTD7 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS07199 | KCTD8 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS07200 | KCTD9 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS21614 | Kctd5 Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS22592 | Kctd4 Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS22593 | Kctd9 Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS28132 | Kctd5 Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS29109 | Kctd4 Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS29110 | Kctd9 Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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