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54819

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4

Inhibitors & Agonists

5

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-114974
    Rivenprost

    ONO-4819; ONO-AE1-734

    		 Prostaglandin Receptor Others Inflammation/Immunology
    Rivenprost (ONO-4819; ONO-AE1-734) is a selective agonist for prostaglandin E receptor EP4 with Ki of 0.7 nM. Rivenprost exhibits hepatoprotective and bone anabolic effects .
    Rivenprost
  • HY-120051
    Afizagabar
    2 Publications Verification

    S44819; Egis-13529

    		 GABA Receptor Neurological Disease
    Afizagabar (S44819) is a first-in-class, competitive, and selective antagonist at the GABA-binding site of the α5-GABAAR, with an IC50 of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. Afizagabar enhances hippocampal synaptic plasticity and exhibits pro-cognitive efficacy .
    Afizagabar
  • HY-15112
    JTP-4819

    		Prolyl Endopeptidase (PREP) Infection
    JTP-4819 is a potent and specific inhibitor of prolyl endopeptidase (PREP) with IC50s of 0.83 nM (in rat brain supernatant) and 5.43 nM (in Flavobacterium meningosepticum). JTP-4819 has blood-brain penetration, also improves the retention time of amnesia rats induced by Scopolamine (HY-N2096) .
    JTP-4819
  • HY-123285
    UK 14819

    5-Desbromo, 5-chloro brimonidine

    		 Adrenergic Receptor Neurological Disease
    UK 14819 (5-Desbromo, 5-chloro brimonidine) is an α2-adrenoceptor agonist. UK 14819 inhibits stimulation-induced contractions of rabbit distal colon with an IC50 of 6.66 nM .
    UK 14819

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